Effects of Motive-Oriented Therapeutic Relationship in the Early-Phase Treatment of Borderline Personality Disorder (MOTR)
Primary Purpose
Borderline Personality Disorder
Status
Completed
Phase
Not Applicable
Locations
Switzerland
Study Type
Interventional
Intervention
Psychiatric Management
Motive-oriented therapeutic relationship/Plan Analysis
Sponsored by
About this trial
This is an interventional treatment trial for Borderline Personality Disorder
Eligibility Criteria
Inclusion Criteria:
- DSM-IV Borderline Personality Disorder;
- between 18 and 65 yrs of age
Exclusion Criteria:
- DSM-IV psychotic disorders,
- mental retardation,
- substance abuse in the forefront
Sites / Locations
- Department of Psychiatry-CHUV, University of Lausanne
Arms of the Study
Arm 1
Arm 2
Arm Type
Active Comparator
Experimental
Arm Label
General Psychiatric Management (GPM; Gunderson & Links, 2008)
GPM plus Motive-Oriented Therapeutic Relationship
Arm Description
psychodynamic-psychiatric treatment for borderline personality disorder
use of Plan Analysis and Motive-oriented therapeutic relationship, as add-on variable to GPM
Outcomes
Primary Outcome Measures
Outcome Questionnaire -45.2 (Lambert et al., 2004)
pre- post- intervention in a randomized controlle trial; measure of symptom reduction over 3 months
Secondary Outcome Measures
Inventory of Interpersonal Problems (Horowitz et al., 1988)
Measure of interpersonal problems after 3 months of therapy
Full Information
NCT ID
NCT01896024
First Posted
July 5, 2013
Last Updated
December 1, 2014
Sponsor
University of Lausanne Hospitals
1. Study Identification
Unique Protocol Identification Number
NCT01896024
Brief Title
Effects of Motive-Oriented Therapeutic Relationship in the Early-Phase Treatment of Borderline Personality Disorder
Acronym
MOTR
Study Type
Interventional
2. Study Status
Record Verification Date
December 2014
Overall Recruitment Status
Completed
Study Start Date
June 2010 (undefined)
Primary Completion Date
May 2013 (Actual)
Study Completion Date
April 2014 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
University of Lausanne Hospitals
4. Oversight
Data Monitoring Committee
No
5. Study Description
Brief Summary
The present research aims at examining the effectiveness of a specific set of therapist relational interventions and attitudes, called the Motive-Oriented Therapeutic Relationship (MOTR), based on Plan Analysis (Caspar, 2007) in the early-phase treatment of patients diagnosed with Borderline Personality Disorder.
The investigators intend to include N = 80 outpatients diagnosed with Borderline Personality Disorder, consulting at the Outpatient Personality Disorder Program of the Karl Jaspers Clinical Unit, in collaboration with the Institute of Psychotherapy, at the Department of Psychiatry-CHUV, University of Lausanne and in collaboration with the University of Berne, Switzerland. Patients are assigned by chance to two treatment conditions 1) Control condition (General Psychiatric Management; Gunderson & Links, 2008) and 2) MOTR-condition. The investigators hypothesize better results in the MOTR-condition, as compared to the control condition in terms of symptom reduction pre-post.
The conduct of the study represents a significant contribution to the understanding and enhancement of relationship aspects in the treatment of patients diagnosed with Borderline Personality Disorder which may be of potential benefit for these patients.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Borderline Personality Disorder
7. Study Design
Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
ParticipantOutcomes Assessor
Allocation
Randomized
Enrollment
85 (Actual)
8. Arms, Groups, and Interventions
Arm Title
General Psychiatric Management (GPM; Gunderson & Links, 2008)
Arm Type
Active Comparator
Arm Description
psychodynamic-psychiatric treatment for borderline personality disorder
Arm Title
GPM plus Motive-Oriented Therapeutic Relationship
Arm Type
Experimental
Arm Description
use of Plan Analysis and Motive-oriented therapeutic relationship, as add-on variable to GPM
Intervention Type
Behavioral
Intervention Name(s)
Psychiatric Management
Intervention Type
Behavioral
Intervention Name(s)
Motive-oriented therapeutic relationship/Plan Analysis
Primary Outcome Measure Information:
Title
Outcome Questionnaire -45.2 (Lambert et al., 2004)
Description
pre- post- intervention in a randomized controlle trial; measure of symptom reduction over 3 months
Time Frame
3 months
Secondary Outcome Measure Information:
Title
Inventory of Interpersonal Problems (Horowitz et al., 1988)
Description
Measure of interpersonal problems after 3 months of therapy
Time Frame
3 months
Other Pre-specified Outcome Measures:
Title
Borderline Symptom List (Bohus, 2009)
Description
Symptom reduction of borderline symptoms over 3 months of treatment
Time Frame
3 months
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
65 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
DSM-IV Borderline Personality Disorder;
between 18 and 65 yrs of age
Exclusion Criteria:
DSM-IV psychotic disorders,
mental retardation,
substance abuse in the forefront
Facility Information:
Facility Name
Department of Psychiatry-CHUV, University of Lausanne
City
Lausanne
State/Province
VD
ZIP/Postal Code
1004
Country
Switzerland
12. IPD Sharing Statement
Citations:
PubMed Identifier
21451348
Citation
Kramer U, Berger T, Kolly S, Marquet P, Preisig M, de Roten Y, Despland JN, Caspar F. Effects of motive-oriented therapeutic relationship in early-phase treatment of borderline personality disorder: a pilot study of a randomized trial. J Nerv Ment Dis. 2011 Apr;199(4):244-50. doi: 10.1097/NMD.0b013e3182125d19.
Results Reference
result
PubMed Identifier
24752034
Citation
Kramer U, Kolly S, Berthoud L, Keller S, Preisig M, Caspar F, Berger T, de Roten Y, Marquet P, Despland JN. Effects of motive-oriented therapeutic relationship in a ten-session general psychiatric treatment of borderline personality disorder: a randomized controlled trial. Psychother Psychosom. 2014;83(3):176-86. doi: 10.1159/000358528. Epub 2014 Apr 17.
Results Reference
result
PubMed Identifier
25324025
Citation
Kramer U, Fluckiger C, Kolly S, Caspar F, Marquet P, Despland JN, de Roten Y. Unpacking the effects of therapist responsiveness in borderline personality disorder: motive-oriented therapeutic relationship, patient in-session experience, and the therapeutic alliance. Psychother Psychosom. 2014;83(6):386-7. doi: 10.1159/000365400. Epub 2014 Oct 16. No abstract available.
Results Reference
result
PubMed Identifier
33256540
Citation
Sallin L, Geissbuehler I, Grandjean L, Beuchat H, Martin-Soelch C, Pascual-Leone A, Kramer U. Self-Contempt, the Working Alliance and Outcome in Treatments for Borderline Personality Disorder: An Exploratory Study. Psychother Res. 2021 Jul;31(6):765-777. doi: 10.1080/10503307.2020.1849848. Epub 2020 Nov 30.
Results Reference
derived
PubMed Identifier
32368793
Citation
Storebo OJ, Stoffers-Winterling JM, Vollm BA, Kongerslev MT, Mattivi JT, Jorgensen MS, Faltinsen E, Todorovac A, Sales CP, Callesen HE, Lieb K, Simonsen E. Psychological therapies for people with borderline personality disorder. Cochrane Database Syst Rev. 2020 May 4;5(5):CD012955. doi: 10.1002/14651858.CD012955.pub2.
Results Reference
derived
PubMed Identifier
29482597
Citation
Penzenstadler L, Kolly S, Rothen S, Khazaal Y, Kramer U. Effects of substance use disorder on treatment process and outcome in a ten-session psychiatric treatment for borderline personality disorder. Subst Abuse Treat Prev Policy. 2018 Feb 26;13(1):10. doi: 10.1186/s13011-018-0145-6.
Results Reference
derived
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Effects of Motive-Oriented Therapeutic Relationship in the Early-Phase Treatment of Borderline Personality Disorder
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