A Dose-response Study of Lidocaine and Etomidate
Etomidate Overdose of Undetermined Intent
About this trial
This is an interventional supportive care trial for Etomidate Overdose of Undetermined Intent focused on measuring iv lidocaine, inducing dose, etomidate, dose response
Eligibility Criteria
Inclusion Criteria:
- Patients scheduled for Elective Surgery,
- age limit within 18-70 years,
- American Society of Anaesthesiologists physical status classification I-II
Exclusion Criteria:
- Adrenal Cortex disorder,
- Neurologic disease,
- Psychiatric disorders,
- Allergic to Local anesthetic drugs,
- Patients who have received sedatives,analgesics or opioids within the previous 24 hrs.
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Placebo Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Control
Lidocaine 1mg/kg
Lidocaine 1.5mg/kg
Lidocaine 2mg/kg
Lidocaine 2.5mg/kg
0.9% Normal Saline is given instead of Lidocaine in the same volume and duration. Then, Etomidate 2mg intravenously every 15 seconds is given until the complete loss of consciousness as detected as the complete loss of eyelash reflex.
Lidocaine 1mg/kg is given intravenously within 2 minutes. Then, Etomidate 2mg intravenously every 15 seconds is given until the complete loss of consciousness as detected as the complete loss of eyelash reflex.
Lidocaine 1.5mg/kg is given intravenously within 2 minutes. Then, Etomidate 2mg intravenously every 15 seconds is given until the complete loss of consciousness as detected as the complete loss of eyelash reflex.
Lidocaine 2mg/kg is given intravenously within 2 minutes. Then, Etomidate 2mg intravenously every 15 seconds is given until the complete loss of consciousness as detected as the complete loss of eyelash reflex.
Lidocaine 2.5mg/kg is given intravenously within 2 minutes. Then, Etomidate 2mg intravenously every 15 seconds is given until the complete loss of consciousness as detected as the complete loss of eyelash reflex.