Study of Repetitive Transcranial Magnetic Stimulation in the Treatment of Cognitive Impairment in Schizophrenia
Schizophrenia
About this trial
This is an interventional treatment trial for Schizophrenia focused on measuring schizophrenia
Eligibility Criteria
Inclusion Criteria:
- 1)patients to be diagnosed according to the Fourth Edition of the Diagnostic and Statistical Manual of Mental Disorders(DSM-IV) for paranoid schizophrenia;2)20~49 years old;3)Duration of 2 ~ 10 years;4)the disease situation is stable, the fluctuation of Positive and Negative Symptom Scale(PANSS)total score ≤10% in last 1 month, and have accepted the current drugs for more than 8 weeks; 5)Patients, their families and doctors are agreed that the disease situation is stable and maintained current drug treatment in next month;6)Signed an informed consent
Exclusion Criteria:
- 1)patients to be diagnosed according to DSM-IV for substance abused,development delayed;2)suffering from serious physical disease and can not accept the treatment;3)repetitive transcranial magnetic stimulation(rTMS) contraindications: intracranial metal substance, with heart pacemakers and cochlear implants, intracranial pressure;4)the disease situation is not stable, the fluctuation of Positive and Negative Symptom Scale(PANSS)total score >10% in last 1 month, Positive and Negative Symptom Scale(PANSS)total score > 60;5)difficult to maintain the current drug treatment for at least 1 month;6)undergoing electroconvulsive therapy(ECT)in last 3 months.
Sites / Locations
- Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine
Arms of the Study
Arm 1
Arm 2
Active Comparator
Sham Comparator
Active rTMS
Sham rTMS
Active treatment will be delivered at an intensity that is 90% of the resting motor threshold (RMT). Stimulation will be delivered at 20 Hz with 100 stimulation trains of 20 stimuli each (i.e., 2000 stimuli) and an inter-train interval of 9 sec. Treatment will be applied in sequential order to the left dorsolateral prefrontal cortex (DLPFC). Intervention: Device: Repetitive Transcranial Magnetic Stimulation
Sham rTMS stimulation will be delivered using the same stimulation parameters and at the site of active treatment, but the coil will be reversed. This method produces sound and some somatic sensation (e.g., contraction of scalp muscles) similar to those of active stimulation, but with minimal direct brain effects.Intervention: Device: Repetitive Transcranial Magnetic Stimulation