Blueberry Effects on Dark Vision and Glare Recovery
Blindness and Low Vision
About this trial
This is an interventional basic science trial for Blindness and Low Vision focused on measuring blueberry, anthocyanin, dark vision, photo bleaching, Visual Perception, Photic Stimulation
Eligibility Criteria
Inclusion Criteria:
- visual acuity better than 6/7.5 on EDTRS acuity chart at 2.5m
- visual contrast sensitivity within normal range at 2.5m as tested on Visteck 3000
- stereo acuity better than 80 seconds of arc on Frisby stereoacuity test
- no ocular history other than refractive glasses
- no family history of eye disease
Exclusion Criteria:
- family history of retinal degeneration, glaucoma, diabetes, hypertension, cataract, or amblyopia (dimness in vision).
- evidence in subject (upon examination) of amblyopia (dimness in vision), manifest strabismus (unable to focus both eyes on one spot), or anisotropia (non-uniform responsiveness between both eyes).
- intraocular pressure above 21mmHG from an average of three measures using Mentor tonopen-XL
Sites / Locations
- Atlantic Food and Horicultural Research Center
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Active Comparator
Active Comparator
Placebo Comparator
No Intervention
Blueberry Juice
Blueberry Capsules
Placebo
Washout (S2 and L1)
Commercially prepared single strength blueberry juice which was composed of a 50:50 blend of two highbush blueberry species (Vaccinium corymbosum L. 'Rubel' and V. ashei Reade 'TifBlue'). Volunteers consumed 300 mls of juice/day (247-271 mg anthocyanins (as C3G) daily) while on this intervention, for either 3 weeks (Blueberry Juice S2) or 12 weeks (Blueberry Juice L1).
Commercially prepared single strength blueberry juice which was composed of a 50:50 blend of two highbush blueberry species (Vaccinium corymbosum L. 'Rubel' and V. ashei Reade 'TifBlue')was freeze dried to a powder and encapsulated in gelatin capsules (Blueberry Capsules S2). Volunteers consumed 3 capsules/daily (7.11mg anthocyanin (as C3G eq) for 3 weeks.
Volunteers consumed in S2 three placebo capsules daily for 3 weeks. In L1 volunteers consumed 300ml placebo juice for twelve weeks. Placebo products contained no anthocyanins.
Washout periods involved no study products. Washout was 3 weeks in S2 and or 8 weeks (L1) in duration.