Visuomotor Prosthetic for Paralysis
Quadriplegia
About this trial
This is an interventional basic science trial for Quadriplegia focused on measuring Neural, Prosthetic, brain machine interface, brain computer interface, brain control, paralysis, tetraplegia, quadriplegia, spinal cord injury
Eligibility Criteria
Inclusion Criteria:
- Pathology resulting in paralysis
- Age 22-65 years
- Able to provide informed consent
- Understand and comply with instructions, if necessary, with the aid of a translator
- Able to communicate via speech
- Surgical clearance
- Life expectancy greater than 12 months
- Live within 60 miles of study location and willing to travel up to 5 days per week
- A regular caregiver to monitor the surgical site
- Psychosocial support system
- Stable ventilator status
Exclusion Criteria:
- Intellectual impairment
- Psychotic illness or chronic psychiatric disorder, including major depression if untreated
- Poor visual acuity
- Pregnancy
- Active infection or unexplained fever
- Scalp lesions or skin breakdown
- HIV or AIDS infection
- Active cancer or chemotherapy
- Medically uncontrolled diabetes
- Autonomic dysreflexia
- History of seizure
- Implanted hydrocephalus shunt
- History of supratentorial brain injury or neurosurgery
- Medical conditions contraindicating surgery and chronic implantation of a medical device
- Unable to undergo MRI or anticipated need for MRI during study
- Nursing an infant or unwilling to bottle-feed infant
- Chronic oral or intravenous use of steroids or immunosuppressive therapy
- Suicidal ideation
- Drug or alcohol dependence
- Planning to become pregnant, or unwilling to use adequate birth control
- Implanted Cardiac Defibrillator, Pacemaker, vagal nerve stimulator, or spinal cord stimulator.
Sites / Locations
- University of California Los AngelesRecruiting
- California Institute of TechnologyRecruiting
- Casa Colina Centers for RehabilitationRecruiting
Arms of the Study
Arm 1
Experimental
Neural Communication System
The Neural Communication System consists of two Neuroport Multi-Port Arrays, which are descried in detail in the intervention description. One Neuroport Multi-Port Array is inserted into the posterior parietal cortex, an area of the brain used in reach planning. The second Neuroport Multi-Port Array is inserted into the motor cortex, which is primarily responsible for controlling movement. The arrays are inserted and the percutaneous pedestal is attached to the skull during a surgical procedure. Following surgical recovery the subject will participate in study sessions 3-5 times per week in which they will learn to use thought to control a simple computer environment or a tablet computer.