The Effect of Topical Administration of Common Drugs on Postoperative Bleeding and Pain
Pain, Postoperative, Postoperative Hemorrhage
About this trial
This is an interventional prevention trial for Pain, Postoperative focused on measuring Administration, topical, tranexamic acid, adrenaline, bupivacaine, surgery
Eligibility Criteria
Inclusion Criteria:
- Patients undergoing unilateral simple mastectomy
- patients undergoing bilateral symmetric breast surgery
Exclusion Criteria:
- pregnancy
- A history of former thromboembolic events (to receive TXA)
- cardiovascular disease (to receive adrenaline)
Sites / Locations
- St Olavs University Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Experimental
Experimental
Experimental
Experimental
Placebo Comparator
Placebo Comparator
topical tranexamic acid
topical adrenaline
topical bupivacaine
topical adrenaline plus tranexamic acid
placebo control
tranexamic acid and placebo control
tranexamic acid to be smeared on surgical wounds before closure
adrenaline solution to be smeared on surgical wounds before closure
bupivacaine to be smeared on surgical wounds before closure
tranexamic acid and adrenaline to be smeared on surgical wounds before closure
saline to be smeared on surgical wounds before closure
tranexamic acid and saline to be smeared on surgical wounds before closure