Use of Streptokinase for Enhancement of Percutaneous Drainage of Pancreatic Necrosis
Acute Pancreatitis
About this trial
This is an interventional treatment trial for Acute Pancreatitis focused on measuring Streptokinase, Percutaneous catheter drainage, Pancreatic necrosis, peripancreatic necrosis
Eligibility Criteria
Inclusion Criteria:
- Patients with severe acute pancreatitis managed by percutaneous catheter drainage
Exclusion Criteria:
- An acute intra abdominal event (perforation of hollow viscus, bleeding, or abdominal compartment syndrome) before or after PCD insertion.
- Previous drainage or surgical necrosectomy for infected pancreatic necrosis (ERCP with or without papillotomy is allowed.)
- Previous exploratory laparotomy for acute abdomen and diagnosis of pancreatitis during laparotomy
- Patients who are allergic to streptokinase.
- Patients with deranged coagulation profile.
- Patients with recent history of cerebrovascular accident [< 2 months], intracranial or intraspinal surgery, uncontrolled hypertension, intracranial neoplasm.
Sites / Locations
- Postgraduate Institute of Medical Education and Research
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Group B [streptokinase]
Group A [placebo]
50000U of injection streptokinase dissolved in 100ml of normal saline instilled in to the pancreatic and/or peripancreatic collections via the percutaneous catheters and clamped for 2 hours. After release of clamp, cavity will be irrigated with 100-500ml of normal saline. This procedure will be done thrice daily for five days
100 ml of normal saline will be instilled through percutaneous catheters in the pancreatic and/or peripancreatic collections and clamped for 2 hours. After release of clamp, cavity will be irrigated with 100-500ml of saline. This procedure will be performed thrice daily for five days