The Investigation of the Pre-movement Facilitation of Agonist-antagonist Muscles and the Effect of the Feedforward Rehabilitation in Individuals With Hypermetria
Primary Purpose
Spinocerebellar Atrophy (SCA)
Status
Completed
Phase
Not Applicable
Locations
Taiwan
Study Type
Interventional
Intervention
Temporal electrical stimulation
Sponsored by
About this trial
This is an interventional treatment trial for Spinocerebellar Atrophy (SCA) focused on measuring Pre-movement facilitation, Fast goal directed movement, Triphasic EMG pattern, Temporal electrical stimulation,, Spinocerebellar Ataxia
Eligibility Criteria
Inclusion Criteria:
- Clinical diagnosis of spinocerebellar ataxia
Sites / Locations
- Chang Gung University
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm Type
Experimental
Experimental
No Intervention
No Intervention
Arm Label
health group 1
SCA group 1
health group 2
SCA group 2
Arm Description
Health subjects received 30 mins delay antagonist activation temporal ES.
SCA subjects received four weeks temporal ES assisted home training program.
health subjects controlled group
SCA subjects controlled group
Outcomes
Primary Outcome Measures
Muscle evoked potential(MEP)
Measure of changes in MEP of flexor carpi radialis.
Electromyography(EMG)
Measure of changes in EMG of flexor carpi radialis and extensor carpi radialis.
Movement error
Measure of changes in movement error during fast 30 degrees wrist extensions.
Secondary Outcome Measures
Full Information
NCT ID
NCT01983670
First Posted
November 7, 2013
Last Updated
November 7, 2013
Sponsor
Chang Gung University
1. Study Identification
Unique Protocol Identification Number
NCT01983670
Brief Title
The Investigation of the Pre-movement Facilitation of Agonist-antagonist Muscles and the Effect of the Feedforward Rehabilitation in Individuals With Hypermetria
Study Type
Interventional
2. Study Status
Record Verification Date
November 2013
Overall Recruitment Status
Completed
Study Start Date
July 2009 (undefined)
Primary Completion Date
June 2012 (Actual)
Study Completion Date
June 2012 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Chang Gung University
4. Oversight
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
In individuals with spino-cerebellar atrophy (SCA), the delayed onset of antagonist muscle firing has been reported to be the cause of hypermetria. Hypermetria is a common deficit in individuals with spino-cerebellar atrophy SCA when they perform ballistic goal-directed movement. Based on the previous studies, ballistic goal-directed movements are controlled by a triphasic pattern of agonistic and antagonistic muscle activation. The origin of the EMG pattern is a central program, whereas the delayed onset of antagonistic muscle firing has been reported to be the cause of hypermetria. To develop a therapy method, the difference in temporal pattern and intensity of supraspinal excitability of agonist and antagonist bursts between healthy adults and individuals with SCA when performing rapid and slow goal-directed movements should be further investigated.
Traditional rehabilitations of individuals with cerebellum lesion were limited to improve the functional performance of movement. Since the deficits of the goal-directed movement are at pre-movement programming, only feedforward training will be possible to re-establish an appropriate program.
Previous showed that peripheral stimulation resulted in a facilitation of motor cortex. Our group also found that this facilitation in individuals with SCA was similar to the ones without SCA. Therefore, it is possible to adjust the control pattern of supraspinal excitability of agonist and antagonist busts of SCA patient with passively providing electrical stimulation contains normal control pattern of healthy human.
The present study sought to investigate the difference in temporal pattern and intensity of supraspinal excitability of agonist and antagonist bursts between healthy adults and individuals with SCA when performing rapid and slow goal-directed movements.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Spinocerebellar Atrophy (SCA)
Keywords
Pre-movement facilitation, Fast goal directed movement, Triphasic EMG pattern, Temporal electrical stimulation,, Spinocerebellar Ataxia
7. Study Design
Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
40 (Actual)
8. Arms, Groups, and Interventions
Arm Title
health group 1
Arm Type
Experimental
Arm Description
Health subjects received 30 mins delay antagonist activation temporal ES.
Arm Title
SCA group 1
Arm Type
Experimental
Arm Description
SCA subjects received four weeks temporal ES assisted home training program.
Arm Title
health group 2
Arm Type
No Intervention
Arm Description
health subjects controlled group
Arm Title
SCA group 2
Arm Type
No Intervention
Arm Description
SCA subjects controlled group
Intervention Type
Other
Intervention Name(s)
Temporal electrical stimulation
Primary Outcome Measure Information:
Title
Muscle evoked potential(MEP)
Description
Measure of changes in MEP of flexor carpi radialis.
Time Frame
Baseline, 4 weeks.
Title
Electromyography(EMG)
Description
Measure of changes in EMG of flexor carpi radialis and extensor carpi radialis.
Time Frame
Baseline, 4 weeks
Title
Movement error
Description
Measure of changes in movement error during fast 30 degrees wrist extensions.
Time Frame
Baseline, 4weeks
10. Eligibility
Sex
All
Minimum Age & Unit of Time
20 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
Clinical diagnosis of spinocerebellar ataxia
Facility Information:
Facility Name
Chang Gung University
City
Taoyuan
ZIP/Postal Code
333
Country
Taiwan
12. IPD Sharing Statement
Citations:
PubMed Identifier
26417459
Citation
Huang YZ, Chang YS, Hsu MJ, Wong AM, Chang YJ. Restoration of Central Programmed Movement Pattern by Temporal Electrical Stimulation-Assisted Training in Patients with Spinal Cerebellar Atrophy. Neural Plast. 2015;2015:462182. doi: 10.1155/2015/462182. Epub 2015 Aug 31.
Results Reference
derived
Learn more about this trial
The Investigation of the Pre-movement Facilitation of Agonist-antagonist Muscles and the Effect of the Feedforward Rehabilitation in Individuals With Hypermetria
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