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The Investigation of the Pre-movement Facilitation of Agonist-antagonist Muscles and the Effect of the Feedforward Rehabilitation in Individuals With Hypermetria

Primary Purpose

Spinocerebellar Atrophy (SCA)

Status
Completed
Phase
Not Applicable
Locations
Taiwan
Study Type
Interventional
Intervention
Temporal electrical stimulation
Sponsored by
Chang Gung University
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Spinocerebellar Atrophy (SCA) focused on measuring Pre-movement facilitation, Fast goal directed movement, Triphasic EMG pattern, Temporal electrical stimulation,, Spinocerebellar Ataxia

Eligibility Criteria

20 Years - undefined (Adult, Older Adult)All SexesAccepts Healthy Volunteers

Inclusion Criteria:

  • Clinical diagnosis of spinocerebellar ataxia

Sites / Locations

  • Chang Gung University

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm 4

Arm Type

Experimental

Experimental

No Intervention

No Intervention

Arm Label

health group 1

SCA group 1

health group 2

SCA group 2

Arm Description

Health subjects received 30 mins delay antagonist activation temporal ES.

SCA subjects received four weeks temporal ES assisted home training program.

health subjects controlled group

SCA subjects controlled group

Outcomes

Primary Outcome Measures

Muscle evoked potential(MEP)
Measure of changes in MEP of flexor carpi radialis.
Electromyography(EMG)
Measure of changes in EMG of flexor carpi radialis and extensor carpi radialis.
Movement error
Measure of changes in movement error during fast 30 degrees wrist extensions.

Secondary Outcome Measures

Full Information

First Posted
November 7, 2013
Last Updated
November 7, 2013
Sponsor
Chang Gung University
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1. Study Identification

Unique Protocol Identification Number
NCT01983670
Brief Title
The Investigation of the Pre-movement Facilitation of Agonist-antagonist Muscles and the Effect of the Feedforward Rehabilitation in Individuals With Hypermetria
Study Type
Interventional

2. Study Status

Record Verification Date
November 2013
Overall Recruitment Status
Completed
Study Start Date
July 2009 (undefined)
Primary Completion Date
June 2012 (Actual)
Study Completion Date
June 2012 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Chang Gung University

4. Oversight

Data Monitoring Committee
Yes

5. Study Description

Brief Summary
In individuals with spino-cerebellar atrophy (SCA), the delayed onset of antagonist muscle firing has been reported to be the cause of hypermetria. Hypermetria is a common deficit in individuals with spino-cerebellar atrophy SCA when they perform ballistic goal-directed movement. Based on the previous studies, ballistic goal-directed movements are controlled by a triphasic pattern of agonistic and antagonistic muscle activation. The origin of the EMG pattern is a central program, whereas the delayed onset of antagonistic muscle firing has been reported to be the cause of hypermetria. To develop a therapy method, the difference in temporal pattern and intensity of supraspinal excitability of agonist and antagonist bursts between healthy adults and individuals with SCA when performing rapid and slow goal-directed movements should be further investigated. Traditional rehabilitations of individuals with cerebellum lesion were limited to improve the functional performance of movement. Since the deficits of the goal-directed movement are at pre-movement programming, only feedforward training will be possible to re-establish an appropriate program. Previous showed that peripheral stimulation resulted in a facilitation of motor cortex. Our group also found that this facilitation in individuals with SCA was similar to the ones without SCA. Therefore, it is possible to adjust the control pattern of supraspinal excitability of agonist and antagonist busts of SCA patient with passively providing electrical stimulation contains normal control pattern of healthy human. The present study sought to investigate the difference in temporal pattern and intensity of supraspinal excitability of agonist and antagonist bursts between healthy adults and individuals with SCA when performing rapid and slow goal-directed movements.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Spinocerebellar Atrophy (SCA)
Keywords
Pre-movement facilitation, Fast goal directed movement, Triphasic EMG pattern, Temporal electrical stimulation,, Spinocerebellar Ataxia

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
40 (Actual)

8. Arms, Groups, and Interventions

Arm Title
health group 1
Arm Type
Experimental
Arm Description
Health subjects received 30 mins delay antagonist activation temporal ES.
Arm Title
SCA group 1
Arm Type
Experimental
Arm Description
SCA subjects received four weeks temporal ES assisted home training program.
Arm Title
health group 2
Arm Type
No Intervention
Arm Description
health subjects controlled group
Arm Title
SCA group 2
Arm Type
No Intervention
Arm Description
SCA subjects controlled group
Intervention Type
Other
Intervention Name(s)
Temporal electrical stimulation
Primary Outcome Measure Information:
Title
Muscle evoked potential(MEP)
Description
Measure of changes in MEP of flexor carpi radialis.
Time Frame
Baseline, 4 weeks.
Title
Electromyography(EMG)
Description
Measure of changes in EMG of flexor carpi radialis and extensor carpi radialis.
Time Frame
Baseline, 4 weeks
Title
Movement error
Description
Measure of changes in movement error during fast 30 degrees wrist extensions.
Time Frame
Baseline, 4weeks

10. Eligibility

Sex
All
Minimum Age & Unit of Time
20 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: Clinical diagnosis of spinocerebellar ataxia
Facility Information:
Facility Name
Chang Gung University
City
Taoyuan
ZIP/Postal Code
333
Country
Taiwan

12. IPD Sharing Statement

Citations:
PubMed Identifier
26417459
Citation
Huang YZ, Chang YS, Hsu MJ, Wong AM, Chang YJ. Restoration of Central Programmed Movement Pattern by Temporal Electrical Stimulation-Assisted Training in Patients with Spinal Cerebellar Atrophy. Neural Plast. 2015;2015:462182. doi: 10.1155/2015/462182. Epub 2015 Aug 31.
Results Reference
derived

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The Investigation of the Pre-movement Facilitation of Agonist-antagonist Muscles and the Effect of the Feedforward Rehabilitation in Individuals With Hypermetria

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