Comparison of Propofol/Alfentanil With Propofol/Ketamine (KET-001)
Lung Disease
About this trial
This is an interventional treatment trial for Lung Disease focused on measuring Ketamine, Alfentanil, Propofol, Oxygen saturation, Percutaneous carbon dioxide, Bronchoscopy
Eligibility Criteria
Inclusion Criteria:
- American Society of Anesthesiologists grade I or II
- patients that will be referred to the procedure for bronchoalveolar lavage and cytologic/bacteriologic sampling, endoluminal biopsies for pathologic /bacteriologic analysis, or for regaining patency (mechanically or laser-assisted) of airways that are obstructed by secretions, tumors or foreign bodies
Exclusion Criteria:
- patient refusal or inability to provide informed consent
- American Society of Anesthesiologists grade III or higher
- allergy to study medications
- patients who have an endotracheal tube or tracheostomy
Sites / Locations
- Pulmonary Institute, Rabin Medical Center, Beilinson Hospital
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
propofol + alfentanil
propofol + ketamine
Patients from the Propofol / Alfentanil group will receive in addition: A loading dose of 10-15 mcg/kg Alfentanil + 0.4 mg/kg Propofol, 2 minutes prior to the beginning of the procedure. Additional boluses of Propofol (aliquots of 10-50 mg) throughout the procedure if required
Patients from the Propofol / Ketamine group will receive in addition: A loading dose of 0.2-0.3 mg/kg Ketamine + 0.4 mg/kg Propofol, 2 minutes prior to the beginning of the procedure. Additional boluses of Propofol (aliquots of 10-50 mg) and/or Ketamine (aliquots of 5-25 mg) throughout the procedure if required.