RCT of Postoperative Infections Following Caesarean Section Infections Following Caesarean Section (APIPICS)
Postoperative Infection

About this trial
This is an interventional treatment trial for Postoperative Infection focused on measuring Randomized Controlled Trial, Caesarean Section, preoperative, intraoperative, prophylactic antibiotics, antibiotics, timing, surgical site infections, endometritis, wound infections, urinary tract infections, infectious morbidity, neonatal antibiotics exposure, Antibiotic Prophylaxis
Eligibility Criteria
All women delivering a child by CS at term, at Odense University Hospital, Hvidovre Hospital or Hospital of South West Jutland, Denmark, will be included in the study. Informed consent will be obtained during pregnancy.
Inclusion Criteria:
- Age ≥ 18 year
- Women, who can read and understand Danish
- A gestational age ≥ completed 28 weeks of gestation
- Rupture of membranes and active labour (uterine contractions) is allowed.
Exclusion Criteria:
- Hypersensitivity to cefuroxime or to any other cephalosporin antibiotics
- Previous immediate and/or severe hypersensitivity reaction to penicillin or any other beta-lactam antibiotic.
Systemic exposure to any antibiotic agent within 1 week before delivery
_ Antibiotic indicated due to PROM, fever or other indications at the time of caesarean section.
- Women being immunologically incompetent (e.g. HIV positive)
Sites / Locations
- Hospital of South West Jutland
- Hvidovre Hospital
- Odense University Hospital
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
præoperativ antibiotic
postoperativ antibiotic
iv Cefuroxime 1,5g administered 15-60 minutes before incision
iv Cefuroxime 1,5g administered after umbilical cord clamping