PRP vs HA Intra-articular Knee Injections for Cartilage Defects
Osteoarthritis
About this trial
This is an interventional treatment trial for Osteoarthritis focused on measuring Articular cartilage, Hyaluronic Acid (HA), Platelet rich plasma (PRP)
Eligibility Criteria
Inclusion Criteria:
Participant is willing and able to give informed consent for participation in the study.
- Male or Female, aged 18 years or above.
- Diagnosed with either early degenerative cartilage lesions (Grade 1-3) as determined by plain radiograph, MRI or intra-operatively (categorised as per Outerbridge/ICRS classification).
- The patient must have more than a four month history of knee pain or swelling whether continuous or intermittent.
Exclusion Criteria:
- Female participants who are pregnant, lactating or planning pregnancy during the course of the study.
- Systemic disorders- DM, RA, SLE
- Major axial deviation (varus>5˚, valgus>5˚)
- Patients suffering from haematological disorders (coagulopathy)
- Patients with severe cardiovascular disease
- Active infection
- Immuno-suppressed patients
- Patients taking anticoagulants such warfarin or low molecular weight heparin
- Haemoglobin levels below 11g/dl
- Platelet count below 150000/mmc
- Participants who have participated in another research study involving an investigational product in the past 12 weeks
Sites / Locations
- Kent Knee Unit
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
HA
PRP
Patients in this arm will have hyaluronic acid (HA) injected into their knee along with 3 ml local anaesthetic. The HA injection is in the form of 2 ml aqueous sodium hyaluronate. The exact constituents of the HA change in a proprietary manner. All HA injections used will have the CE marking on them.
Patients in this arm will have platelet rich plasma (PRP) injected into their knee. The PRP sample will be produced at the time of the injection. 30 ml of blood is drawn fro the patient a few minutes before the injection. Using a CE marked differential centrifugation device, the platelets are isolated. This concentrated sample of platelets is injected into the knee after the skin around the injection site is anaesthetised with local anaesthetic.