Laparoscopic Hepatectomy Versus Open Hepatectomy for PHC

This is an interventional treatment trial for Primary Liver Carcinoma focused on measuring Laparoscope hepatectomy, Open hepatectomy, large PHC, safety and sensibility Read More

Inclusion Criteria:

• Inclusion criteria for the Laparoscope hepatectomy group are:

  1. both male and female, aged 18 to 70;
  2. PHC diagnosis is clear preoperative;
  3. No active hepatitis and decompensated cirrhosis
  4. tumor size of 5-10 cm,no intrahepatic or distant metastasis,no tumor thrombus in the portal vein, hepatic vein, vena cava, or bile duct; and no invasion of the diaphragm or surrounding tissues;
  5. no rupture or bleeding of the tumor;
  6. Child-Pugh class A or B liver function;
  7. indocyanine green retention rate at 15 min of <15%, and a remnant liver volume/standard liver volume ratio of >50% in patients with liver cirrhosis and >35% in patients without liver cirrhosis;
  8. upper abdominal surgery, radiofrequency ablation, Transhepatic Arterial Chemotherapy And Embolization treatment, radiotherapy and chemotherapy have not been implemented and no previous surgery that absolutely contraindicated Laparoscope hepatectomy.
  9. General condition of patients and cardiopulmonary function enough to tolerate surgery
  10. voluntary participation in the study, and informed consent.
• Inclusion criteria for the Open hepatectomy group are:

meet the criteria for Laparoscope hepatectomy group;

Exclusion Criteria:

• (1) age <18 years or> 70 years , pregnant or lactating women; (2) tumor size ≥10 cm, or tumor location that would interfere with intraoperative exposure and isolation of the hepatic hilum; (3) tumor encroaching on the hepatic hilum , the portal vein, primary bile duct or tumor adjacent to the major vascular structures ; (4) unable to tolerate a pneumoperitoneum or can't tolerate surgery duo to cardiopulmonary dysfunction; (5) severe upper abdominal adhesions; (6)Pathologically confirmed positive margins