Randomized Trial of Transcranial Theta-burst Stimulation and Transcranial Direct Current Stimulation
Stroke
About this trial
This is an interventional treatment trial for Stroke focused on measuring stroke, brain stimulation, electroencephalography, functional magnetic resonance imaging, functional connectivity
Eligibility Criteria
Inclusion Criteria:
- ischemic or hemorrhagic stroke leading to unilateral deficits in motor function with significant impact on independence and daily activities at the beginning of rehabilitation
- less than 10 weeks after stroke onset.
Exclusion Criteria:
- epileptic seizures
- metallic objects in the brain
- presence of implants or neural stimulators
- pregnancy
- sleep deprivation
- recent traumatic brain injury
- delirium or disturbed vigilance
- inability to participate in 1h treatment sessions
- severe language comprehension deficits
- skull breach
- new stroke lesions during rehabilitation
- medical complications
Sites / Locations
- Service de Neurorééducation, Unversity Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Active Comparator
Sham Comparator
cTBS
cathodal tDCS
sham stimulation
A transcranial magnetic stimulator (MagPro X100, Medtronic Functional Diagnostics, Skovlunde, Denmark) will deliver continuous bursts of bipolar magnetic pulses exerting an inhibition on the underlying brain tissue (cTBS). The stimulation coil will be placed over the unaffected primary motor cortex. The stimulation protocol implies 200 bursts, each consisting of three pulses applied at 30 Hz, repeated at inter-burst intervals of 167 ms. Two stimulation trains of 30 s, separated by 15 min, will be applied 3 times per week for 3 weeks and will be immediately followed by physical therapy.
A stimulator (NeuroConn GmbH, Illmenau, Germany) will deliver cathodal transcranial direct current stimulation (tDCS) of the unaffected motor cortex. The anode will be placed over the contralateral supraorbital region. Stimulation will be performed for 25 min, 3 times per week for 3 weeks during upper extremity treatment sessions.
This group will receive the same stimulation protocol as used for the active groups except that sham stimuli will be applied. Half of the patients receive sham cTBS, the other half sham tDCS.