The Effects of Auditory Cueing on Rhythmic Movement and Cortical Excitability in Patients With Parkinson's Disease
Primary Purpose
Parkinson's Disease
Status
Unknown status
Phase
Not Applicable
Locations
Taiwan
Study Type
Interventional
Intervention
rhythmic auditory stimulation
Sponsored by
About this trial
This is an interventional treatment trial for Parkinson's Disease focused on measuring Parkinson's disease, Auditory Cueing
Eligibility Criteria
Inclusion Criteria:
- Clinical diagnosis of Parkinson disease
Exclusion Criteria:
- Clinical diagnosis of other neurological diseases
- Dementia
- Been diagnosed with any mental illness
- History of seizures
- Brain trauma
- Body with a pacemaker or other electrical stimulator
- Pregnancy
Sites / Locations
- Chang Gung UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
No Intervention
Arm Label
intervention group
Control group
Arm Description
intervention group which receive auditory cueing while performing movement
control group which performing movement after listen to required movement rhythm.
Outcomes
Primary Outcome Measures
Finger Tapping
Record pre-test and post-test change.
Motor evoked potential
Use single-pulse TMS to assess Motor evoked potential change.
Intracortical inhibition & Intracortical facilitation
Use paired-pulse TMS to record pre-test and post-test change.
Blood oxygen dependent level
Use Near-infrared spectroscopy to record pre-test, in experiment, and post-test change.
Secondary Outcome Measures
Full Information
NCT ID
NCT02037451
First Posted
January 14, 2014
Last Updated
January 14, 2014
Sponsor
Chang Gung University
1. Study Identification
Unique Protocol Identification Number
NCT02037451
Brief Title
The Effects of Auditory Cueing on Rhythmic Movement and Cortical Excitability in Patients With Parkinson's Disease
Study Type
Interventional
2. Study Status
Record Verification Date
January 2014
Overall Recruitment Status
Unknown status
Study Start Date
August 2013 (undefined)
Primary Completion Date
August 2014 (Anticipated)
Study Completion Date
August 2014 (Anticipated)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Chang Gung University
4. Oversight
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
Parkinson's disease (PD) is a progressive degenerative disease of central nervous systems deficit. The clinical symptoms of Parkinson's disease include the following motor tasks: difficult in initiating movement, performing rhythmic movement or serial movement, the ability of learning motor movement is also affected. The primary treatment for Parkinson's disease is medical treatment; surgery is used if in need. Rehabilitation such as physical therapy, which aims to improve patient's quality of life and functions, is a non-invasive treatment and value for PD patients. Auditory cue is a technique that widely applied on training patients with Parkinson's disease, and some researches revealed that auditory cueing could improve motor performance. However, the mechanism under this treatment technique is still unknown.
This study is to investigate the effect of auditory cueing on rhythmic finger movement in patients with Parkinson's disease. To investigate the mechanism under auditory cueing, neurophysiological data such as motor cortex excitability and blood flow in cortical cortex will be obtained by using Transcranial magnetic stimulation (TMS) and near infrared spectroscopy (NIRS).
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Parkinson's Disease
Keywords
Parkinson's disease, Auditory Cueing
7. Study Design
Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Crossover Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
38 (Anticipated)
8. Arms, Groups, and Interventions
Arm Title
intervention group
Arm Type
Experimental
Arm Description
intervention group which receive auditory cueing while performing movement
Arm Title
Control group
Arm Type
No Intervention
Arm Description
control group which performing movement after listen to required movement rhythm.
Intervention Type
Procedure
Intervention Name(s)
rhythmic auditory stimulation
Intervention Description
Participants perform the finger tapping at the same time give rhythmic auditory stimulation ,and need to execute tapping with auditory stimulation.
Primary Outcome Measure Information:
Title
Finger Tapping
Description
Record pre-test and post-test change.
Time Frame
Baseline,45-60 minutes.
Title
Motor evoked potential
Description
Use single-pulse TMS to assess Motor evoked potential change.
Time Frame
Baseline,45-60 minute
Title
Intracortical inhibition & Intracortical facilitation
Description
Use paired-pulse TMS to record pre-test and post-test change.
Time Frame
Baseline,45-60 minutes
Title
Blood oxygen dependent level
Description
Use Near-infrared spectroscopy to record pre-test, in experiment, and post-test change.
Time Frame
Baseline, in experiment,45-60 minutes
10. Eligibility
Sex
All
Minimum Age & Unit of Time
20 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
Clinical diagnosis of Parkinson disease
Exclusion Criteria:
Clinical diagnosis of other neurological diseases
Dementia
Been diagnosed with any mental illness
History of seizures
Brain trauma
Body with a pacemaker or other electrical stimulator
Pregnancy
Facility Information:
Facility Name
Chang Gung University
City
Taoyuan
ZIP/Postal Code
333
Country
Taiwan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ya-Ju Chang, PhD
Phone
88632118800
Ext
5515
Email
yjchang@mail.cgu.edu.tw
12. IPD Sharing Statement
Learn more about this trial
The Effects of Auditory Cueing on Rhythmic Movement and Cortical Excitability in Patients With Parkinson's Disease
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