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Metabolic Response to Playing Video Games: Two Arm Trial

Primary Purpose

Appetite and General Nutritional Disorders, Sedentary Lifestyle

Status
Unknown status
Phase
Not Applicable
Locations
United Kingdom
Study Type
Interventional
Intervention
Competitive video game
Little Big Planet
Sponsored by
University College, London
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional basic science trial for Appetite and General Nutritional Disorders focused on measuring Appetite, metabolism, sedentary behaviour, stress response

Eligibility Criteria

18 Years - 30 Years (Adult)MaleAccepts Healthy Volunteers

Inclusion Criteria:

  • Healthy adult males with BMI <25 kg/m2

Exclusion Criteria:

  • smoking
  • a significant weight change (>3kg) within the previous three months
  • any psychiatric disorder
  • uncontrolled hypertension
  • coronary heart disease
  • heart failure
  • central/peripheral arteriopathies
  • excessive alcohol consumption (<21 units/week).

Sites / Locations

  • UCL Institute of Child HealthRecruiting

Arms of the Study

Arm 1

Arm 2

Arm Type

Active Comparator

Experimental

Arm Label

Problem-solving video game

Competitive video game

Arm Description

Playing the video game 'Little Big Planet'

Playing the video game 'Call of Duty'

Outcomes

Primary Outcome Measures

Food intake
Subjects will be offered a selection of snacks and drinks over a 20 minute period, and their rates of food intake will be calculated

Secondary Outcome Measures

Blood pressure
Blood pressure will be measured in duplicate at 1 minute intervals by digital instrument
Heart rate
Heart rate will be measured using a polar digital heart rate monitor
Salivary leptin
Salivary leptin will be analysed using ELISA
Salivary ghrelin
Salivary ghrelin will be assessed using ELISA
Salivary cortisol
Salivary cortisol will be assessed using ELISA
Visual analogue scale
Visual analogue scale will be used to collect subjective data on mood and appetite
Grip strength
Grip strength will be assessed by hand-grip dynamometer, using the average of three measurements for each arm
Memory recall
Subjects will be shown images for a set time to allow memorization, and then be given another set time to recall as many of these images as possible

Full Information

First Posted
February 24, 2014
Last Updated
February 27, 2014
Sponsor
University College, London
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1. Study Identification

Unique Protocol Identification Number
NCT02075827
Brief Title
Metabolic Response to Playing Video Games: Two Arm Trial
Official Title
Metabolic Response to Playing Video Games: Two Arm Trial
Study Type
Interventional

2. Study Status

Record Verification Date
February 2014
Overall Recruitment Status
Unknown status
Study Start Date
February 2014 (undefined)
Primary Completion Date
October 2014 (Anticipated)
Study Completion Date
undefined (undefined)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
University College, London

4. Oversight

Data Monitoring Committee
No

5. Study Description

Brief Summary
Previous studies have shown that subjects who play video games are prone to consume larger quantities of food than subjects who are simply resting. This is believed to be due to the development of a stress response in the video games group, resulting in increased fuel metabolism. However, it was shown that the energy intake of the two groups showed no correlation with the subjects' appetite/hunger, which was identical in both groups. The investigators propose to explore this issue further by comparing the effects of different types of video games on metabolism, using a randomized controlled trial. In this study, they will compare the stress levels, heart rate, blood pressure, appetite/mood, energy consumption, grip strength, memory and saliva cortisol, leptin and ghrelin levels of subjects playing (a) competitive and (b) problem-solving video games. Measurements will be taken preceding, during and after the 1 hour intervention. Following the intervention, participants will be offered savoury and sweet foods/drinks, which will allow us to assess their appetite preferences and caloric intake. The investigators first aim is to determine whether there is a significant difference in stress levels, eating habits and energy metabolism in the two groups. Our second aim is to determine whether there is a difference in glucose distribution to the muscles and brain between the two groups.
Detailed Description
The investigators study is designed to test experimentally whether different kinds of video game generate different types of metabolic response. The exposure comprises one-hour of video game playing, with 36 young men randomized to each group (ie 72 in total). Prior to the exposure, they will collect baseline data on heart rate, blood pressure, anthropometry (weight, height, waist girth), grip strength and cognitive function (memory test), as well as appetite/mood by visual analogue scale (VAS). The investigators will also collect a baseline saliva sample to assess hormones associated with stress (cortisol) or satiety (leptin, ghrelin). The subject will arrive after and overnight fast and will be given a standardised breakfast. After these baseline data are collected, the randomization envelope will be opened and the subject assigned to his group. Heart rate will be monitored continuously during the study. At 20 and 40 minutes during the intervention, as well as when it ceases at 60 minutes, the investigators will collect further data on blood pressure and appetite/mood by VAS. At 60 minutes, the investigators will repeat measurement of memory and grip strength, and collect a second saliva sample. For 20 minutes after the end of the intervention, the subject will be allowed to rest, reading magazines, and will be able to select from a range of snack foods (savoury, sweet, fruit), and drinks (sweetened beverages, water). Consumption of calories will be calculated. At the end of this period, final measurements of blood pressure and VAS will be collected, and the subject will depart.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Appetite and General Nutritional Disorders, Sedentary Lifestyle
Keywords
Appetite, metabolism, sedentary behaviour, stress response

7. Study Design

Primary Purpose
Basic Science
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
72 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Problem-solving video game
Arm Type
Active Comparator
Arm Description
Playing the video game 'Little Big Planet'
Arm Title
Competitive video game
Arm Type
Experimental
Arm Description
Playing the video game 'Call of Duty'
Intervention Type
Behavioral
Intervention Name(s)
Competitive video game
Other Intervention Name(s)
'Call of Duty' (Activision)
Intervention Description
1 hour playing video game
Intervention Type
Behavioral
Intervention Name(s)
Little Big Planet
Other Intervention Name(s)
Little Big Planet (Sony Computer Entertainment
Intervention Description
1 hour playing video game
Primary Outcome Measure Information:
Title
Food intake
Description
Subjects will be offered a selection of snacks and drinks over a 20 minute period, and their rates of food intake will be calculated
Time Frame
At end of 1-hour video game intervention
Secondary Outcome Measure Information:
Title
Blood pressure
Description
Blood pressure will be measured in duplicate at 1 minute intervals by digital instrument
Time Frame
At 20, 40 and 60 minutes of intervention, and after 20 minutes rest post-intervention
Title
Heart rate
Description
Heart rate will be measured using a polar digital heart rate monitor
Time Frame
Continuously, starting during baseline period, from 0 to 60 minutes during intervention, and for 20 minutes post-intervention rest period
Title
Salivary leptin
Description
Salivary leptin will be analysed using ELISA
Time Frame
After 60 minutes from start of intervention
Title
Salivary ghrelin
Description
Salivary ghrelin will be assessed using ELISA
Time Frame
After 60 minutes from start of intervention
Title
Salivary cortisol
Description
Salivary cortisol will be assessed using ELISA
Time Frame
After 60 minutes from start of intervention
Title
Visual analogue scale
Description
Visual analogue scale will be used to collect subjective data on mood and appetite
Time Frame
At 20, 40 and 60 minutes of intervention, and after 20 minutes rest post-intervention
Title
Grip strength
Description
Grip strength will be assessed by hand-grip dynamometer, using the average of three measurements for each arm
Time Frame
After 60 minutes from start of intervention
Title
Memory recall
Description
Subjects will be shown images for a set time to allow memorization, and then be given another set time to recall as many of these images as possible
Time Frame
After 60 minutes from start of intervention

10. Eligibility

Sex
Male
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
30 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: Healthy adult males with BMI <25 kg/m2 Exclusion Criteria: smoking a significant weight change (>3kg) within the previous three months any psychiatric disorder uncontrolled hypertension coronary heart disease heart failure central/peripheral arteriopathies excessive alcohol consumption (<21 units/week).
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Panos Michael
Phone
+44(0)7546842700
Email
panos.michael.11@ucl.ac.uk
First Name & Middle Initial & Last Name or Official Title & Degree
Jonathan CK Wells, PhD
Phone
+44(0)2079052389
Email
Jonathan.Wells@ucl.ac.uk
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Jonathan CK Wells, PhD
Organizational Affiliation
UCL Institute of Child Health
Official's Role
Principal Investigator
Facility Information:
Facility Name
UCL Institute of Child Health
City
London
ZIP/Postal Code
WC1N 1EH
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Panos Michael
Phone
+44(0)7546842700
Email
panos.michael.11@ucl.ac.uk
First Name & Middle Initial & Last Name & Degree
Jonathan CK Wells, PhD

12. IPD Sharing Statement

Citations:
PubMed Identifier
24084510
Citation
Siervo M, Sabatini S, Fewtrell MS, Wells JC. Acute effects of violent video-game playing on blood pressure and appetite perception in normal-weight young men: a randomized controlled trial. Eur J Clin Nutr. 2013 Dec;67(12):1322-4. doi: 10.1038/ejcn.2013.180. Epub 2013 Oct 2.
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Metabolic Response to Playing Video Games: Two Arm Trial

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