Treatment of Eating Disorders by Physical Activity and Nutrition Counseling (FAKT)
Primary Purpose
Bulimia Nervosa, Binge Eating Disorder
Status
Completed
Phase
Not Applicable
Locations
Norway
Study Type
Interventional
Intervention
Cognitive Behaviour Therapy
Physical Activity and Dietary Therapy
Sponsored by
About this trial
This is an interventional treatment trial for Bulimia Nervosa focused on measuring BN, Binge, overconsumption of food, purging, purge
Eligibility Criteria
Inclusion Criteria:
- Women,
- BMI 17,5-35,
- Age of 18-40 years,
- DSM-5 criteria of bulimia nervosa,
- DSM-5 criteria of Binge eating disorder
- Living nearby Norwegian School of Sports Sciences, NSSS, in Oslo (Norway)
Exclusion Criteria:
- Age <18 and >40 years
- BMI <17,5 and >35
- Pregnancy
- Competing/experienced athlete
- Anorexia nervosa
- Currently, or during the past 2 years, in active treatment with cognitive therapy
- Other personality disturbances
- Suicidality
Sites / Locations
- Norwegian School of Sports Sciences
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Experimental
Arm Label
Cognitive Behaviour Therapy
Physical activity and dietary therapy
Arm Description
Treatment with small groups following a modified protocol first described by Fairburn 2008
Treatment with guided physical activity and dietary therapy in small groups
Outcomes
Primary Outcome Measures
Effectiveness of treatment, evaluated through the change in symptoms of eating disorder
Change in ED-symptoms are evaluated through screening and surveys: EDE-questionaire (Episodes of binge eating, episodes of purging, concern for body weight and appearance)(Fairburn, 2008), Clinical Impairment Assessment (CIA) (Fairburn, 2008), Eating Disorder Inventory-3 (EDI) (Garner, 2004), Eating Disturbance Scale (EDS-5) (Rosenvinge et al., 2000), DSM-5 (APA, 2013)
Secondary Outcome Measures
Expectations of treatment method for eating disorders
Interview on the expectations the patients have to the specified treatment method of eating disorders (arm of intervention) EPDEX (Clinton 2001)
Experiences of the treatment method for eating disorders
Interview on the experiences the patients have to the specified treatment method of eating disorders (arm of intervention), EPDEX (Clinton 2001)
Associated cost with treatment method
Calculation of the directly and indirectly cost related to treatment method
Associated cost with treatment method
Calculation of the directly and indirectly cost related to treatment method
Associated cost With treatment method
Calculation of the directly and indirectly cost related to treatment method
Associated cost With treatment method
Calculation of the directly and indirectly cost related to treatment method
Associated cost with treatment method
Calculation of the directly and indirectly cost related to treatment method
Global measurement of general psychopathology
Beck's Anxiety Inventory (BAI), Beck Depression Inventory (BDI), QoL (Diener), Utrecht Coping List, Resilience Scale for Adults, the outcome rating scale (ORS), the three-factor eating questionnaire (TFEQ), Binge eating Scale (BES), Cantril's Ladder, Exercise dependency test, compulsice exercise test
Global measurement of general psychopathology
Beck's Anxiety Inventory (BAI), Beck Depression Inventory (BDI), QoL (Diener), Utrecht Coping List, Resilience Scale for Adults, the outcome rating scale (ORS), the three-factor eating questionnaire (TFEQ), Binge eating Scale (BES), Cantril's Ladder, Exercise dependency test, compulsice exercise test
Global measurement of general psychopathology
Beck's Anxiety Inventory (BAI), Beck Depression Inventory (BDI), QoL (Diener), Utrecht Coping List, Resilience Scale for Adults, the outcome rating scale (ORS), the three-factor eating questionnaire (TFEQ), Binge eating Scale (BES), Cantril's Ladder, Exercise dependency test, compulsice exercise test
Global measurement of general psychopathology
Beck's Anxiety Inventory (BAI), Beck Depression Inventory (BDI), QoL (Diener), Utrecht Coping List, Resilience Scale for Adults, the outcome rating scale (ORS), the three-factor eating questionnaire (TFEQ), Binge eating Scale (BES), Cantril's Ladder, Exercise dependency test, compulsice exercise test
Global measurement of general psychopathology
Beck's Anxiety Inventory (BAI), Beck Depression Inventory (BDI), QoL (Diener), Utrecht Coping List, Resilience Scale for Adults, the outcome rating scale (ORS), the three-factor eating questionnaire (TFEQ), Binge eating Scale (BES), Cantril's Ladder, Exercise dependency test, compulsice exercise test
Group climate
coerciveness scale from Therapeutic Factor Inventory (Lese & MacNair-Semands, 2000).
Working AIliance
Working AIliance Inventory (Horwath & Greenberg, 1989)
Experiences of the treatment method for eating disorders
Interview on the experiences the patients have to the specified treatment method of eating disorders (arm of intervention) (Clinton 2001)
Experiences of the treatment method for eating disorders
Interview on the experiences the patients have to the specified treatment method of eating disorders (arm of intervention) (Clinton 2001)
Experiences of the treatment method for eating disorders
Interview on the experiences the patients have to the specified treatment method of eating disorders (arm of intervention) (Clinton 2001)
Change in eating disorder behavior and cognitions related to body figure and bodyweight
Evaluation after each therapy session on progress in reducing eating disordered behaviour (binging and purging) and on changes of cognitions on body figure and -weight
Full Information
NCT ID
NCT02079935
First Posted
February 17, 2014
Last Updated
March 11, 2019
Sponsor
Norwegian School of Sport Sciences
Collaborators
The Norwegian Women´s Public Health Association, University of Tromso
1. Study Identification
Unique Protocol Identification Number
NCT02079935
Brief Title
Treatment of Eating Disorders by Physical Activity and Nutrition Counseling
Acronym
FAKT
Official Title
Treatment of Eating Disorders - a Randomised, Controlled, Prospective Study
Study Type
Interventional
2. Study Status
Record Verification Date
March 2019
Overall Recruitment Status
Completed
Study Start Date
March 2014 (Actual)
Primary Completion Date
January 31, 2019 (Actual)
Study Completion Date
January 31, 2019 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Norwegian School of Sport Sciences
Collaborators
The Norwegian Women´s Public Health Association, University of Tromso
4. Oversight
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
"Eating disorders" includes anorexia nervosa, bulimia nervosa, binge eating and other specified feeding or eating disorder (OSFED). Common to all is the intensively occupation to control food intake, body image and body weight. Most people with this kind of disorder don't reach for professional help, or there may be more than 4 years before they do. Cognitive behavior therapy is the foremost method of treatment of eating disorders, but up to 30-50% of the patients don't respond to this. The investigators find it important to identify science based alternatives of therapy, as this may reduce the health concern, and broaden the choice of therapy methods. A former study by Sundgot-Borgen et al in 2002, found guided physical activity to reduce symptoms of bulimia nervosa just as good as the traditional cognitive therapy.
The primary objective of the project is to see whether the combination of physical exercise and dietary therapy is more effective in treating eating disorders, than cognitive therapy.
Secondly, the investigators want to see whether there are any differences with regard to the individual satisfaction of treatment method, and to associated costs. Interviews with a sufficient number of participants from the PED-t arm to meet data saturation criteria, and all theraphists in the new treatment offer, will give uniqe insight to experiences with the treatment method and the delivery of treatment.
Detailed Description
Subjects are recruited through primary doctors, social media and newspapers, and will be included continuously by screening interviews. There will be a randomization into two treatment groups (cognitive behavior, or physical activity and nutrition education) to be followed for 16 weeks. Each week includes one meeting of group therapy (90 minutes) and homework related to treatment, and for 4 weeks midway there will be two therapy meetings pr week (a total of 20 meetings). Post tests are planned at week 17, and at 6, 12, and 24 months after treatment.
Participants reqruited during ongoing treatment groups are placed on a waitlist, serving as controls to the treatment groups.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Bulimia Nervosa, Binge Eating Disorder
Keywords
BN, Binge, overconsumption of food, purging, purge
7. Study Design
Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Model Description
Comparing treatment of cognitive behavioural therapy, with treatment of physical exercise and dietary therapy. All participants randomized to either of the two treatment offers. Waitlist serves as control group.
Masking
Outcomes Assessor
Masking Description
The one transferring results from lab's and questionaires to SPSS are blinded for group affiliation.
Allocation
Randomized
Enrollment
128 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Cognitive Behaviour Therapy
Arm Type
Experimental
Arm Description
Treatment with small groups following a modified protocol first described by Fairburn 2008
Arm Title
Physical activity and dietary therapy
Arm Type
Experimental
Arm Description
Treatment with guided physical activity and dietary therapy in small groups
Intervention Type
Behavioral
Intervention Name(s)
Cognitive Behaviour Therapy
Other Intervention Name(s)
CBT-ED, CBT-enhanced, CBT-e
Intervention Description
Following group-modified protocol for cognitive behavioral therapy, CBT, first described by Fairburn 2008, modified by Modum Bad, Norway.
Intervention Type
Behavioral
Intervention Name(s)
Physical Activity and Dietary Therapy
Other Intervention Name(s)
PADT, FAKT, PED-t
Intervention Description
Guided physical activity and dietary therapy, to (re-)introduce a more healthy lifestyle and help stabilizing a healthy weight. A detailed manual will be published.
Primary Outcome Measure Information:
Title
Effectiveness of treatment, evaluated through the change in symptoms of eating disorder
Description
Change in ED-symptoms are evaluated through screening and surveys: EDE-questionaire (Episodes of binge eating, episodes of purging, concern for body weight and appearance)(Fairburn, 2008), Clinical Impairment Assessment (CIA) (Fairburn, 2008), Eating Disorder Inventory-3 (EDI) (Garner, 2004), Eating Disturbance Scale (EDS-5) (Rosenvinge et al., 2000), DSM-5 (APA, 2013)
Time Frame
Pre-test in week 0, Post-tests (week 17), and at 6, 12, and 24 months after intervention.
Secondary Outcome Measure Information:
Title
Expectations of treatment method for eating disorders
Description
Interview on the expectations the patients have to the specified treatment method of eating disorders (arm of intervention) EPDEX (Clinton 2001)
Time Frame
Pre-test
Title
Experiences of the treatment method for eating disorders
Description
Interview on the experiences the patients have to the specified treatment method of eating disorders (arm of intervention), EPDEX (Clinton 2001)
Time Frame
Post-test (week 17)
Title
Associated cost with treatment method
Description
Calculation of the directly and indirectly cost related to treatment method
Time Frame
Pre-test
Title
Associated cost with treatment method
Description
Calculation of the directly and indirectly cost related to treatment method
Time Frame
Post-test (week 17)
Title
Associated cost With treatment method
Description
Calculation of the directly and indirectly cost related to treatment method
Time Frame
Post-test (by 6th month post-treatment)
Title
Associated cost With treatment method
Description
Calculation of the directly and indirectly cost related to treatment method
Time Frame
Post-test (by 12th month post-treatment)
Title
Associated cost with treatment method
Description
Calculation of the directly and indirectly cost related to treatment method
Time Frame
Post-test (by 24th month post-treatment)
Title
Global measurement of general psychopathology
Description
Beck's Anxiety Inventory (BAI), Beck Depression Inventory (BDI), QoL (Diener), Utrecht Coping List, Resilience Scale for Adults, the outcome rating scale (ORS), the three-factor eating questionnaire (TFEQ), Binge eating Scale (BES), Cantril's Ladder, Exercise dependency test, compulsice exercise test
Time Frame
Pre-treatment
Title
Global measurement of general psychopathology
Description
Beck's Anxiety Inventory (BAI), Beck Depression Inventory (BDI), QoL (Diener), Utrecht Coping List, Resilience Scale for Adults, the outcome rating scale (ORS), the three-factor eating questionnaire (TFEQ), Binge eating Scale (BES), Cantril's Ladder, Exercise dependency test, compulsice exercise test
Time Frame
Post-treatment (week 17)
Title
Global measurement of general psychopathology
Description
Beck's Anxiety Inventory (BAI), Beck Depression Inventory (BDI), QoL (Diener), Utrecht Coping List, Resilience Scale for Adults, the outcome rating scale (ORS), the three-factor eating questionnaire (TFEQ), Binge eating Scale (BES), Cantril's Ladder, Exercise dependency test, compulsice exercise test
Time Frame
Post-treatment (by the 6th month post-treatment)
Title
Global measurement of general psychopathology
Description
Beck's Anxiety Inventory (BAI), Beck Depression Inventory (BDI), QoL (Diener), Utrecht Coping List, Resilience Scale for Adults, the outcome rating scale (ORS), the three-factor eating questionnaire (TFEQ), Binge eating Scale (BES), Cantril's Ladder, Exercise dependency test, compulsice exercise test
Time Frame
Post-test (by 12th month post-treatment)
Title
Global measurement of general psychopathology
Description
Beck's Anxiety Inventory (BAI), Beck Depression Inventory (BDI), QoL (Diener), Utrecht Coping List, Resilience Scale for Adults, the outcome rating scale (ORS), the three-factor eating questionnaire (TFEQ), Binge eating Scale (BES), Cantril's Ladder, Exercise dependency test, compulsice exercise test
Time Frame
Post-test (by 24th month post-treatment)
Title
Group climate
Description
coerciveness scale from Therapeutic Factor Inventory (Lese & MacNair-Semands, 2000).
Time Frame
week 1-16
Title
Working AIliance
Description
Working AIliance Inventory (Horwath & Greenberg, 1989)
Time Frame
week 1-16
Title
Experiences of the treatment method for eating disorders
Description
Interview on the experiences the patients have to the specified treatment method of eating disorders (arm of intervention) (Clinton 2001)
Time Frame
Post-test (6 months)
Title
Experiences of the treatment method for eating disorders
Description
Interview on the experiences the patients have to the specified treatment method of eating disorders (arm of intervention) (Clinton 2001)
Time Frame
Post-test (by 12th month post-treatment)
Title
Experiences of the treatment method for eating disorders
Description
Interview on the experiences the patients have to the specified treatment method of eating disorders (arm of intervention) (Clinton 2001)
Time Frame
Post-test (by 24th month post-treatment)
Title
Change in eating disorder behavior and cognitions related to body figure and bodyweight
Description
Evaluation after each therapy session on progress in reducing eating disordered behaviour (binging and purging) and on changes of cognitions on body figure and -weight
Time Frame
Week 1-16 during treatment
Other Pre-specified Outcome Measures:
Title
Change in muscular strength
Description
Status of 1 repetition maximum, 1RM, muscular strength in squats, bench press and seated row
Time Frame
Pretest (week 0), post-test (week 17) and at 6, 12 and 24 months after treatment
Title
Change in cardiovascular endurance
Description
CPET: with the use of modified Balke Treadmill performance evaluation test, The Borg scale (Borg, 1982)
Time Frame
Pre-test in week 0, Post-tests ( week 17), and at 6, 12 and 24 months after intervention.
Title
Change in bone mineral density
Description
DXA (Dual-energy X-ray absorptiometry)
Time Frame
Pre-test in week 0, Post-test (week 17) and 6, 12, and 24 months post-treatment
Title
Change in body weight and bodycomposition
Description
DXA (dual-energy x-ray absorptiometry) (weekly weight registration will also be kept in each arm of treatment)
Time Frame
Pre-test and post-test (week 17) and at 6,12,18 and 24 months post-treatment
Title
Change in nutritional status
Description
Blood test to identify nutritional status of iron, folate, cholesterol and triglycerides, ApoA, ApoB and vitamin-D, folic acid
Time Frame
Pre-test, in week 8 of treatment, post-test (week 17) and at 6,12,18 and 24 months post-treatment
Title
Change in hormonal status
Description
Blood test to evaluate hormonal status of estradiol, progesterone, CTX, P1nP, insulin, leptin, TSH, T3, T4, FSH, LH, cortisol
Time Frame
Pre-test, week 8 of treatment, post-test (week 17) and at 6,12,18 and 24 months post-treatment
Title
Change in dietary and nutritional intake
Description
24 hour recall interview: interview on the intake of food and beverage during the past 24 hours.
Time Frame
Pre-test, each 3rd week in treatment (a total of 5 interviews), post-test (week 17), and post-treatment (6,12, and 24 months post-treatment)
Title
Change in physical activity level
Description
Wearing a GT3X-BT actigraph accelerometer for 7 consecutive days and making notes on daily activity in 30 minutes intervals
Time Frame
Pre-test in week 0, Post-test (week 17) and 6, 12, and 24 months post-treatment
Title
Interview: measure and explore patients experienced treatment satisfaction and outcome/benefits with PED-t.
Description
Qualitative approaches, such as in-depth interviews, will give additional insights into ED-patients' perspectives, notably experiences and satisfaction with the treatment. A sufficient number of participants to meet data saturation criteria are qualitatively interviewed.
Data are analyzed in four steps within the framework of systematic text condensation (Malterud 2012).
Time Frame
Post treatment
Title
Interview: What are the theraphists experiences of their contribution to the PED-t program
Description
Qualitative approaches, such as in-depth interviews, will give additional insights into the therapists' perspectives and experiences on delivering a new treatment offer for eating disorder.
Data are analyzed in four steps within the framework of systematic text condensation (Malterud 2012).
Time Frame
Post treatment
Title
Interview: What are the experiences of the participants who drop out of the PED-t program?
Description
Data are analyzed in four steps within the framework of systematic text condensation (Malterud 2012).
Time Frame
Post treatment
10. Eligibility
Sex
Female
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
40 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
Women,
BMI 17,5-35,
Age of 18-40 years,
DSM-5 criteria of bulimia nervosa,
DSM-5 criteria of Binge eating disorder
Living nearby Norwegian School of Sports Sciences, NSSS, in Oslo (Norway)
Exclusion Criteria:
Age <18 and >40 years
BMI <17,5 and >35
Pregnancy
Competing/experienced athlete
Anorexia nervosa
Currently, or during the past 2 years, in active treatment with cognitive therapy
Other personality disturbances
Suicidality
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Jorunn Sundgot-Borgen, Professor
Organizational Affiliation
Norwegian School of Sports Sciences
Official's Role
Study Chair
First Name & Middle Initial & Last Name & Degree
Therese F Mathisen, PhDcandidate
Organizational Affiliation
Norwegian School of Sports Sciences
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Jan Rosenvinge, Professor
Organizational Affiliation
University of Tromso
Official's Role
Study Director
Facility Information:
Facility Name
Norwegian School of Sports Sciences
City
Oslo
ZIP/Postal Code
0806
Country
Norway
12. IPD Sharing Statement
Plan to Share IPD
Undecided
Citations:
PubMed Identifier
11828224
Citation
Sundgot-Borgen J, Rosenvinge JH, Bahr R, Schneider LS. The effect of exercise, cognitive therapy, and nutritional counseling in treating bulimia nervosa. Med Sci Sports Exerc. 2002 Feb;34(2):190-5. doi: 10.1097/00005768-200202000-00002.
Results Reference
result
PubMed Identifier
31944339
Citation
Mathisen TF, Rosenvinge JH, Friborg O, Vrabel K, Bratland-Sanda S, Pettersen G, Sundgot-Borgen J. Is physical exercise and dietary therapy a feasible alternative to cognitive behavior therapy in treatment of eating disorders? A randomized controlled trial of two group therapies. Int J Eat Disord. 2020 Apr;53(4):574-585. doi: 10.1002/eat.23228. Epub 2020 Jan 16.
Results Reference
derived
PubMed Identifier
31005919
Citation
Pettersen G, Rosenvinge JH, Skomakerstuen T, Sordal S, Mathisen TF, Sundgot-Borgen J. Patient expectations of a new treatment for eating disorders combining guided physical exercise and dietary therapy: an interview study of women participating in a randomised controlled trial at the Norwegian School of Sport Sciences. BMJ Open. 2019 Apr 20;9(4):e025344. doi: 10.1136/bmjopen-2018-025344.
Results Reference
derived
PubMed Identifier
30559966
Citation
Mathisen TF, Bratland-Sanda S, Rosenvinge JH, Friborg O, Pettersen G, Vrabel KA, Sundgot-Borgen J. Treatment effects on compulsive exercise and physical activity in eating disorders. J Eat Disord. 2018 Dec 13;6:43. doi: 10.1186/s40337-018-0215-1. eCollection 2018.
Results Reference
derived
PubMed Identifier
29473191
Citation
Mathisen TF, Rosenvinge JH, Friborg O, Pettersen G, Stensrud T, Hansen BH, Underhaug KE, Teinung E, Vrabel K, Svendsen M, Bratland-Sanda S, Sundgot-Borgen J. Body composition and physical fitness in women with bulimia nervosa or binge-eating disorder. Int J Eat Disord. 2018 Apr;51(4):331-342. doi: 10.1002/eat.22841. Epub 2018 Feb 23.
Results Reference
derived
PubMed Identifier
29415831
Citation
Mathisen TF, Engen KM, Sundgot-Borgen J, Stensrud T. Evaluation of a short protocol for indirect calorimetry in females with eating disorders and healthy controls. Clin Nutr ESPEN. 2017 Dec;22:28-35. doi: 10.1016/j.clnesp.2017.09.003. Epub 2017 Oct 5.
Results Reference
derived
PubMed Identifier
29330176
Citation
Bakland M, Sundgot-Borgen J, Wynn R, Rosenvinge JH, Stornaes AV, Pettersen G. Therapists' experiences with a new treatment combining physical exercise and dietary therapy (the PED-t) for eating disorders: an interview study in a randomised controlled trial at the Norwegian School of Sport Sciences. BMJ Open. 2018 Jan 11;8(1):e019386. doi: 10.1136/bmjopen-2017-019386.
Results Reference
derived
PubMed Identifier
29317417
Citation
Pettersen G, Rosenvinge JH, Bakland M, Wynn R, Mathisen TF, Sundgot-Borgen J. Patients' and therapists' experiences with a new treatment programme for eating disorders that combines physical exercise and dietary therapy: the PED-t trial. A qualitative study protocol. BMJ Open. 2018 Jan 8;8(1):e018708. doi: 10.1136/bmjopen-2017-018708.
Results Reference
derived
PubMed Identifier
29259061
Citation
Pettersen G, Sordal S, Rosenvinge JH, Skomakerstuen T, Mathisen TF, Sundgot-Borgen J. How do women with eating disorders experience a new treatment combining guided physical exercise and dietary therapy? An interview study of women participating in a randomised controlled trial at the Norwegian School of Sport Sciences. BMJ Open. 2017 Dec 19;7(12):e018588. doi: 10.1136/bmjopen-2017-018588.
Results Reference
derived
PubMed Identifier
28494809
Citation
Mathisen TF, Rosenvinge JH, Pettersen G, Friborg O, Vrabel K, Bratland-Sanda S, Svendsen M, Stensrud T, Bakland M, Wynn R, Sundgot-Borgen J. The PED-t trial protocol: The effect of physical exercise -and dietary therapy compared with cognitive behavior therapy in treatment of bulimia nervosa and binge eating disorder. BMC Psychiatry. 2017 May 12;17(1):180. doi: 10.1186/s12888-017-1312-4.
Results Reference
derived
Links:
URL
http://www.nih.no/en/
Description
Norwegian School of Sports Sciences
URL
http://www.sanitetskvinnene.no/
Description
The Norwegian Women's Public Health Association
URL
http://en.uit.no/startsida
Description
University of Tromsø
URL
http://translate.google.com/translate?hl=no&langpair=no%7Cen&u=http://www.modum-bad.no/
Description
Modum Bad
URL
http://nihfakt.blogspot.no/
Description
Recruitment webpage
Learn more about this trial
Treatment of Eating Disorders by Physical Activity and Nutrition Counseling
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