Microfracture Versus Adipose Derived Stem Cells for the Treatment of Articular Cartilage Defects
Degenerative Lesion of Articular Cartilage of Knee
About this trial
This is an interventional treatment trial for Degenerative Lesion of Articular Cartilage of Knee focused on measuring cartilage/transplantation, cartilage, articular/injuries, cartilage, articular/surgery, chondrocytes/cytology, knee injuries/surgery, knee joint/surgery, orthopedic procedures/methods, tissue engineering, tissue scaffolds, arthroscopy/methods, chondrocytes/transplantation, adipose tissue/cytology, cartilage, articular/cytology, chondrogenesis/physiology, osteogenesis/physiology, stem cell transplantation/methods, stem cells, tissue engineering/methods, cartilage, articular/pathology, chondrocytes/pathology, knee joint/pathology, platelet-rich plasma
Eligibility Criteria
Inclusion Criteria:
- Must be between ages 18 and 50 years.
- Must have a discrete, contained chondral defect less than 400mm^2 located on the medial or lateral femoral condyle
- Must have overall neutral lower limb mechanical alignment (<5 degrees varus or valgus).
Exclusion Criteria:
- Ages younger than 18 years and older than 50 years.
- If they have undergone previous chondral procedures
- If they have pre-existing osteoarthritis (Kellegren-Lawrence Grade ≥2)
- If they have a BMI >30.
Sites / Locations
- Stanford Medical Outpatient Center
- Kerlan Jobe Orthopedic InstituteRecruiting
- UC Health Steadman Hawkins Clinic - Denver InvernessRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
ADSC Application
Microfracture Arm
Patients undergo an arthroscopic surgical procedure, ADSC application, followed by physical therapy.
Patients undergo an arthroscopic surgical procedure, microfracture, followed by physical therapy.