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Study to Examine the Effects of ATP Supplementation on Muscle Excitability and Reaction Time During and Following a Repeated Sprint Bout

Primary Purpose

Muscle Fatigue Caused by Repetitive Muscle Exercise

Status
Completed
Phase
Not Applicable
Locations
United States
Study Type
Interventional
Intervention
Placebo
ATP
Sponsored by
Metabolic Technologies Inc.
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional basic science trial for Muscle Fatigue Caused by Repetitive Muscle Exercise

Eligibility Criteria

18 Years - 30 Years (Adult)MaleAccepts Healthy Volunteers

Inclusion Criteria:

  • Agree to eating a diet approved by a registered dietician consisting of the following by caloric percentages: 15-20% protein, 44-55% carbohydrate, and 25-30% fat.
  • Must not have taken performance enhancing supplements for at least 3 months prior to the study start,
  • Must be a non-smoker.
  • Must not be taking amino acid supplements.
  • Must not be using anabolic or catabolic hormones.
  • Must not be taking any medications known to influence variables to be measured in the study.

Exclusion Criteria:

  • Will not agree to eating a diet approved by a registered dietician consisting of the following by caloric percentages: 15-20% protein, 44-55% carbohydrate, and 25-30% fat.
  • Has taken performance enhancing supplements for at least 3 months prior to the study start,
  • Is currently a non-smoker.
  • Is currently taking amino acid supplements.
  • Is currently using anabolic or catabolic hormones.
  • Is currently taking medications known to influence variables to be measured in the study.

Sites / Locations

  • Jacob M Wilson, PhD

Arms of the Study

Arm 1

Arm 2

Arm Type

Placebo Comparator

Active Comparator

Arm Label

Placebo

ATP

Arm Description

This arm will serve as the placebo supplementation.

This arm will serve as the treatment intervention, ATP

Outcomes

Primary Outcome Measures

Muscle Excitability
Muscle excitability will be measured using Delsys Wireless Electromyography (EMG) sensors.

Secondary Outcome Measures

Power
Muscle power will be measured using the Wingate and vertical jump power measures.

Full Information

First Posted
March 18, 2014
Last Updated
September 24, 2015
Sponsor
Metabolic Technologies Inc.
Collaborators
University of Tampa
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1. Study Identification

Unique Protocol Identification Number
NCT02093611
Brief Title
Study to Examine the Effects of ATP Supplementation on Muscle Excitability and Reaction Time During and Following a Repeated Sprint Bout
Official Title
Study to Examine the Effects of ATP Supplementation on Muscle Excitability and Reaction Time During and Following a Repeated Sprint Bout
Study Type
Interventional

2. Study Status

Record Verification Date
September 2015
Overall Recruitment Status
Completed
Study Start Date
July 2013 (undefined)
Primary Completion Date
August 2015 (Actual)
Study Completion Date
August 2015 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Metabolic Technologies Inc.
Collaborators
University of Tampa

4. Oversight

Data Monitoring Committee
No

5. Study Description

Brief Summary
We hypothesize that adenosine-5'-triphosphate (ATP) supplementation will be able to enhance motor unit recruitment while simultaneously blunting the decline in power and reaction time that is typically seen during repetitive sprints. This will give researchers a better understanding of the mechanism by which ATP supplementation can augment power, especially under high fatiguing conditions.
Detailed Description
Healthy participants of similar training status as previously tested will be enrolled into the study. The participants will be randomly assigned to either placebo supplementation or to 400 mg ATP per day for 14 days. The supplements will be taken in the morning and the last dose will be taken 30 min prior to testing on the last day. Testing will be performed at baseline and after the 14 days of supplementation. Ten successive sprints will be conducted on the Wingate apparatus as this has been previously demonstrated to decrease muscle excitability. After the sprints, muscle excitability, reaction time, and vertical jump power will be measured. In addition a blood sample will be obtained before and after supplementation and complete blood hematology and chemistry analyses will be performed. It is expected that ATP supplementation may help maintain muscle excitability and power after the successive sprint sessions.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Muscle Fatigue Caused by Repetitive Muscle Exercise

7. Study Design

Primary Purpose
Basic Science
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
ParticipantCare ProviderInvestigator
Allocation
Randomized
Enrollment
42 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Placebo
Arm Type
Placebo Comparator
Arm Description
This arm will serve as the placebo supplementation.
Arm Title
ATP
Arm Type
Active Comparator
Arm Description
This arm will serve as the treatment intervention, ATP
Intervention Type
Dietary Supplement
Intervention Name(s)
Placebo
Other Intervention Name(s)
Placebo Comparator
Intervention Type
Dietary Supplement
Intervention Name(s)
ATP
Other Intervention Name(s)
Peak ATP
Intervention Description
400 mg of ATP
Primary Outcome Measure Information:
Title
Muscle Excitability
Description
Muscle excitability will be measured using Delsys Wireless Electromyography (EMG) sensors.
Time Frame
Day 14
Secondary Outcome Measure Information:
Title
Power
Description
Muscle power will be measured using the Wingate and vertical jump power measures.
Time Frame
Day 14
Other Pre-specified Outcome Measures:
Title
Reaction Time
Description
Reaction time will be measured using a Dynavision apparatus.
Time Frame
Day 14
Title
Blood Biochemical Analyses
Description
Blood chemistries and hematology will be measured after the 14 days of supplementation.
Time Frame
Day 14

10. Eligibility

Sex
Male
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
30 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: Agree to eating a diet approved by a registered dietician consisting of the following by caloric percentages: 15-20% protein, 44-55% carbohydrate, and 25-30% fat. Must not have taken performance enhancing supplements for at least 3 months prior to the study start, Must be a non-smoker. Must not be taking amino acid supplements. Must not be using anabolic or catabolic hormones. Must not be taking any medications known to influence variables to be measured in the study. Exclusion Criteria: Will not agree to eating a diet approved by a registered dietician consisting of the following by caloric percentages: 15-20% protein, 44-55% carbohydrate, and 25-30% fat. Has taken performance enhancing supplements for at least 3 months prior to the study start, Is currently a non-smoker. Is currently taking amino acid supplements. Is currently using anabolic or catabolic hormones. Is currently taking medications known to influence variables to be measured in the study.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
John A Rathmacher, PhD
Organizational Affiliation
Metabolic Technologies Inc.
Official's Role
Study Director
Facility Information:
Facility Name
Jacob M Wilson, PhD
City
Tampa
State/Province
Florida
ZIP/Postal Code
33606
Country
United States

12. IPD Sharing Statement

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Study to Examine the Effects of ATP Supplementation on Muscle Excitability and Reaction Time During and Following a Repeated Sprint Bout

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