Effects of Neurocognitive and Social Cognitive Remediation in Patients at Ultra-High Risk of Psychosis (FOCUS)
Patients at Ultra-high Risk of Psychosis
About this trial
This is an interventional treatment trial for Patients at Ultra-high Risk of Psychosis focused on measuring Ultra-high risk psychosis, Schizophrenia prodrome, Cognitive remediation
Eligibility Criteria
Inclusion Criteria:
- Age 18-40 yrs.
Fulfill criteria for being at Ultra-High Risk of psychosis (defined by one or more of the following):
- Vulnerability (Trait and State Risk Factor) Group: Individuals with a combination of a trait risk factor (schizotypal personality disorder or a family history of psychotic disorder in a first degree relative) and a significant deterioration in functioning, or sustained low functioning during the past year.
- Attenuated Psychotic Symptoms (APS) Group: Individuals with sub-threshold (intensity or frequency) positive psychotic symptoms. The symptoms must have been present during the past year.
- Brief Limited Intermittent Psychotic Symptoms Group (BLIPS): Individuals with a recent history of frank psychotic symptoms that resolved spontaneously (without antipsychotic medication) within one week. The symptoms must have been present during the past year.
- Provided informed consent.
Exclusion Criteria:
- Past history of a treated or untreated psychotic episode of one week's duration or longer
- Psychiatric symptoms that are explained by a physical illness with psychotropic effect or acute intoxication (e.g., cannabis use).
- Diagnosis of a serious developmental disorder, e.g,. Asperger's syndrome
- Currently receiving treatment with metylphenidate.
- Rejects providing informed consent.
Sites / Locations
- Mental Health Centre Copenhagen
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Standard treatment + cognitive remediation
Standard treatment
The cognitive remediation therapy targets neurocognition as well as social cognition.
Patients allocated to the control condition are free to choose whatever standard treatment they are offered by the clinicians managing their treatment. Usually standard treatment consists of regular contact to health professionals in the in- and outpatient facilities in Copenhagen, Denmark, and encompass different kinds of supportive counselling