Effectiveness Study of Circumferential vs. Segmental Ablation in Paroxysmal Atrial Fibrillation (PAF)
Paroxysmal Atrial Fibrillation, Atrial Arrhythmia
About this trial
This is an interventional treatment trial for Paroxysmal Atrial Fibrillation focused on measuring atrial fibrillation, paroxysmal atrial fibrillation, PAF, arrhythmia, atrial fibrillation ablation, circumferential ablation, CPVA, segmental ablation, PVI, pulmonary vein isolation
Eligibility Criteria
Inclusion Criteria:
- Patients with paroxysmal atrial fibrillation, whose episodes have never been documented to exceed 48 hours duration
- Patients with a clinical indication for ablation
- Patients greater than 18 years of age.
- Patients willing and able to give informed consent.
- Patients with concurrent atrial fibrillation and atrial flutter are allowed.
Exclusion Criteria:
- Patients with medical conditions that would limit participation for the entire duration of the study.
- Patients that are pregnant (all females of child-bearing potential must have a negative pregnancy test within 1 week of enrollment).
- Patients having undergone prior AF ablation
- Patients with paroxysmal atrial fibrillation whose episodes last greater than 48 hours
- Patients with persistent AF
Sites / Locations
- UCSD Sulpizio Cardiovascular Center
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Circumferential Pulmonary Vein Ablation
Segmental Pulmonary Vein Isolation
Contiguous ablation lesions will be performed to encircle the two left and right pulmonary veins (PVs), guided by 3D electroanatomic mapping (Carto, Biosense Webster, Inc. or ESI NavX, St. Jude, Inc.) with a 3D LA geometry created either by using the roving mapping catheter or by importing a pre-recorded 3D CT image of the left atrium. After completion of the circumferential ablation, PV isolation will be confirmed by the mapping catheter, and further focal ablation performed as required until electrical PV isolation is confirmed (entrance block at a minimum).
Electrical potentials recorded in the pulmonary vein (PV) ostium using a circular mapping catheter, representing myocardial connections between the left atrium and PVs will be ablated at or just proximal to the PV ostium in the PV antrum. Ablation will be performed segmentally at multiple sites guided by the mapping catheter around the PV ostium or antrum, until mapping demonstrates elimination of all PV potentials (entrance block at a minimum).