Clinical Value of Noninvasive Intracranial Pressure Measurement (Braincare)
Intracranial Hypertension
About this trial
This is an interventional diagnostic trial for Intracranial Hypertension focused on measuring ICP, intracranial hypertension, Vittamed 205
Eligibility Criteria
Inclusion Criteria:
- Chronic daily headache with suspected idiopathic intracranial hypertension
- Diagnosed of suspected multiple sclerosis (MS)
- Intracranial hemorrhage/ stroke
Exclusion Criteria:
- Patient not able to understand information about the trial
- Uncooperative patient
- Intracranial hemorrhage volume <20 or >40ml
- Stroke area larger than 1/3 of the middle cerebral artery
Sites / Locations
- Hospital of Lithuanian University of Health Sciences Kauno KlinikosRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Experimental
Experimental
Chronic daily headache group
Multiple sclerosis group
Stroke group
Normal pressure hydrocephalus group
Patients with chronic daily headache with suspicion of intracranial hypertension selected. Selection based on clinical symptoms (headache description, leading symptoms)and para-clinical pathological findings (optical nerve papilla edema). Not enough evidence to diagnose any other headache type. Simultaneous CSF pressure measurements and non-invasive ICP measurement will be performed. Interventions: non-invasive intracranial pressure measurement; lumbar puncture and cerebrospinal fluid pressure measurement; brain MRI/CT.
Multiple sclerosis (MS) group patients selected based on clinical symptoms and brain MRI changes typical for the disease. Diagnosis based on McDonalds criteria. CSF test for oligoclonal bands required as supporting diagnostic criteria. Patients selected with disease relapse symptoms. Simultaneous noninvasive ICP and CSF pressure measured. Interventions: non-invasive intracranial pressure measurement; lumbar puncture and cerebrospinal fluid pressure measurement; brain MRI/CT
Patients selected for this group have stroke/intracranial hemorrhage that might be complicated with intracranial hypertension. Stroke/intracranial hemorrhage diagnosed based on clinical findings and changes on brain CT/MRI. Patients with stroke less than 33% of middle cerebral artery territory included. Patients with intracranial hemorrhage 20-40 ml volume included. Patients unable to cooperate or sign informed consent excluded. Bilateral non-invasive ICP measurements performed. Results compared with brain MRI/CT lesion volume, mid-line shift. Interventions: non-invasive intracranial pressure measurement; brain MRI/CT
Patients meeting normal pressure hydrocephalus diagnosis criteria selected to compare invasive CSF pressure versus non-invasive ICP. Interventions: non-invasive intracranial pressure measurement; lumbar puncture and cerebrospinal fluid pressure measurement; brain MRI/CT