A Pilot Study Using Rocuronium to Prevent Intermediate Syndrome After Organophosphorus Insecticide Poisoning
Organophosphate Poisoning
About this trial
This is an interventional treatment trial for Organophosphate Poisoning focused on measuring Organophosphate poisoning, Intermediate syndrome, Rocuronium
Eligibility Criteria
Inclusion criteria:
- Male or female
- Age over 16
- Clinical diagnosis of OP insecticide poisoning
- Admission to Intensive Care Unit for Ventilation
- Informed consent from family
- Train of four measurement > 50%
Exclusion criteria:
- Age 16 or under
- Pregnant
- Consent not obtained from patient or patient's family
Sites / Locations
- Peradeniya Teaching Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Active Comparator
No Intervention
Rocuronium with >95% inhibition
Rocuronium with 50% inhibition
No Rocuronium
IV Rocuronium to be given: Bolus dose of Rocuronium 0.3 mg/kg to achieve >95% inhibition as indicated by Train of Four monitoring Continuous infusion of 1.5 mg/kg/hr to maintain level of inhibition To continue until two rises in butyrylcholinesterase seen or for a maximum of 5 days
IV Rocuronium to be given: Bolus dose of Rocuronium 0.3 mg/kg to achieve 50% inhibition as indicated by Train of Four monitoring Continuous infusion of 1.5 mg/kg/hr to maintain level of inhibition To continue until two rises in butyrylcholinesterase seen or for a maximum of 5 days
No Rocuronium will be given