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Computer-Based Auditory Rehabilitation

Primary Purpose

Presbycusis

Status
Completed
Phase
Not Applicable
Locations
United States
Study Type
Interventional
Intervention
Video game based training 1
Video game based training 2
Sponsored by
Massachusetts Eye and Ear Infirmary
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Presbycusis focused on measuring Presbycusis, Hearing In Noise, Hearing Impairment, Hearing Loss, Aging, Plasticity, Video Games, Perceptual Learning

Eligibility Criteria

50 Years - 85 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Binaural sensorineural hearing impairment
  • Use of binaural hearing aids
  • Native English Speaker

Exclusion Criteria:

  • Significant cognitive impairment
  • Significant motor impairment
  • History of neurological disease/head trauma
  • Use of psychotropic and thyroid medications

Sites / Locations

  • Massachusetts Eye and Ear Infirmary
  • Saint Elizabeth's Medical Center
  • Hudson Valley Audiology Center

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Experimental

Arm Label

Video game based training 1

Video game based training 2

Arm Description

Video Game play with training strategy 1

Video Game play with training strategy 2

Outcomes

Primary Outcome Measures

Speech Perception in Noise
Participants will report words spoken by a target speaker while several speakers serve as distractors.

Secondary Outcome Measures

Frequency Modulation Detection
We will measure the detectability of frequency excursions psychoacoustically.
Stroop Task
Participants will be asked to attend and report one feature of a stimulus while ignoring another
Letter-Numbers Sequencing Test
Participants are asked to repeat a string of letters and numbers.

Full Information

First Posted
May 15, 2014
Last Updated
October 17, 2016
Sponsor
Massachusetts Eye and Ear Infirmary
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1. Study Identification

Unique Protocol Identification Number
NCT02147847
Brief Title
Computer-Based Auditory Rehabilitation
Official Title
Neurological Treatment to Improve the Hearing in Noise Abilities of Older Adults With Hearing Impairments.
Study Type
Interventional

2. Study Status

Record Verification Date
May 2016
Overall Recruitment Status
Completed
Study Start Date
April 2015 (undefined)
Primary Completion Date
August 2016 (Actual)
Study Completion Date
August 2016 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Massachusetts Eye and Ear Infirmary

4. Oversight

Data Monitoring Committee
No

5. Study Description

Brief Summary
Hearing in noisy environments is a perceptual problem that is ubiquitous in modern industrialized societies. This particular listening context offers a particular challenge to individuals living with hearing impairment (30 million in US alone) even after treatment with hearing aids or cochlear implants. The ability of the brain to extract regularities from the environment and suppress distracting information can be improved with intensive cognitive training. The investigators will test whether the hearing in noise abilities of adults living with hearing impairment can be improved with a cognitive training paradigm.
Detailed Description
Hearing impairment (HI) represents the most common cause of moderate to severe disability in the world, with an estimated prevalence of 636 million individuals (30 million in the US alone). Amplification devices (i.e., hearing aids) are commonly used to compensate for HI stemming from acoustic trauma, ototoxic insult, normal aging or other sources of cochlear degeneration. The chief complaint of individuals with HI is hearing in the types of noisy environments that characterize most work, educational, and social situations. Unfortunately, hearing aids do not completely address the perceptual impairments in these situations. That is because the difficulties that individuals with HI have hearing in noise result from the reduced salience of cues that are used to sort out auditory scenes. Making sounds louder improves audibility, but does not afford adaptation of the brain to the abnormal coding of sensory information by the damaged cochlea. The investigators will test whether the hearing in noise abilities of adults living with hearing impairment can be improved with a cognitive training paradigm.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Presbycusis
Keywords
Presbycusis, Hearing In Noise, Hearing Impairment, Hearing Loss, Aging, Plasticity, Video Games, Perceptual Learning

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
ParticipantCare ProviderInvestigatorOutcomes Assessor
Allocation
Randomized
Enrollment
36 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Video game based training 1
Arm Type
Experimental
Arm Description
Video Game play with training strategy 1
Arm Title
Video game based training 2
Arm Type
Experimental
Arm Description
Video Game play with training strategy 2
Intervention Type
Behavioral
Intervention Name(s)
Video game based training 1
Intervention Description
32 one-hour, home-based training sessions over 8 weeks
Intervention Type
Behavioral
Intervention Name(s)
Video game based training 2
Intervention Description
32 one-hour, home-based training sessions over 8 weeks
Primary Outcome Measure Information:
Title
Speech Perception in Noise
Description
Participants will report words spoken by a target speaker while several speakers serve as distractors.
Time Frame
up to 3 months
Secondary Outcome Measure Information:
Title
Frequency Modulation Detection
Description
We will measure the detectability of frequency excursions psychoacoustically.
Time Frame
up to 3 months
Title
Stroop Task
Description
Participants will be asked to attend and report one feature of a stimulus while ignoring another
Time Frame
up to 3 months
Title
Letter-Numbers Sequencing Test
Description
Participants are asked to repeat a string of letters and numbers.
Time Frame
up to 3 months

10. Eligibility

Sex
All
Minimum Age & Unit of Time
50 Years
Maximum Age & Unit of Time
85 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Binaural sensorineural hearing impairment Use of binaural hearing aids Native English Speaker Exclusion Criteria: Significant cognitive impairment Significant motor impairment History of neurological disease/head trauma Use of psychotropic and thyroid medications
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Daniel Polley, Ph.D.
Organizational Affiliation
Massachusetts Eye and Ear Infirmary, Harvard Medical School
Official's Role
Principal Investigator
Facility Information:
Facility Name
Massachusetts Eye and Ear Infirmary
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02114
Country
United States
Facility Name
Saint Elizabeth's Medical Center
City
Brighton
State/Province
Massachusetts
ZIP/Postal Code
02135
Country
United States
Facility Name
Hudson Valley Audiology Center
City
New City
State/Province
New York
ZIP/Postal Code
10956
Country
United States

12. IPD Sharing Statement

Citations:
PubMed Identifier
23401541
Citation
Anderson S, White-Schwoch T, Parbery-Clark A, Kraus N. Reversal of age-related neural timing delays with training. Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):4357-62. doi: 10.1073/pnas.1213555110. Epub 2013 Feb 11.
Results Reference
background
PubMed Identifier
17896103
Citation
Keeling MD, Calhoun BM, Kruger K, Polley DB, Schreiner CE. Spectral integration plasticity in cat auditory cortex induced by perceptual training. Exp Brain Res. 2008 Feb;184(4):493-509. doi: 10.1007/s00221-007-1115-9. Epub 2007 Sep 21.
Results Reference
background
PubMed Identifier
15534214
Citation
Polley DB, Heiser MA, Blake DT, Schreiner CE, Merzenich MM. Associative learning shapes the neural code for stimulus magnitude in primary auditory cortex. Proc Natl Acad Sci U S A. 2004 Nov 16;101(46):16351-6. doi: 10.1073/pnas.0407586101. Epub 2004 Nov 8.
Results Reference
background
PubMed Identifier
16672673
Citation
Polley DB, Steinberg EE, Merzenich MM. Perceptual learning directs auditory cortical map reorganization through top-down influences. J Neurosci. 2006 May 3;26(18):4970-82. doi: 10.1523/JNEUROSCI.3771-05.2006.
Results Reference
background
PubMed Identifier
21912514
Citation
Li RW, Ngo C, Nguyen J, Levi DM. Video-game play induces plasticity in the visual system of adults with amblyopia. PLoS Biol. 2011 Aug;9(8):e1001135. doi: 10.1371/journal.pbio.1001135. Epub 2011 Aug 30.
Results Reference
background
PubMed Identifier
16999250
Citation
Sweetow RW, Sabes JH. The need for and development of an adaptive Listening and Communication Enhancement (LACE) Program. J Am Acad Audiol. 2006 Sep;17(8):538-58. doi: 10.3766/jaaa.17.8.2.
Results Reference
background
PubMed Identifier
15286790
Citation
Bao S, Chang EF, Woods J, Merzenich MM. Temporal plasticity in the primary auditory cortex induced by operant perceptual learning. Nat Neurosci. 2004 Sep;7(9):974-81. doi: 10.1038/nn1293. Epub 2004 Aug 1.
Results Reference
background
PubMed Identifier
12774121
Citation
Green CS, Bavelier D. Action video game modifies visual selective attention. Nature. 2003 May 29;423(6939):534-7. doi: 10.1038/nature01647.
Results Reference
background
PubMed Identifier
20833324
Citation
Green CS, Pouget A, Bavelier D. Improved probabilistic inference as a general learning mechanism with action video games. Curr Biol. 2010 Sep 14;20(17):1573-9. doi: 10.1016/j.cub.2010.07.040.
Results Reference
background
PubMed Identifier
24556432
Citation
Deveau J, Ozer DJ, Seitz AR. Improved vision and on-field performance in baseball through perceptual learning. Curr Biol. 2014 Feb 17;24(4):R146-7. doi: 10.1016/j.cub.2014.01.004. No abstract available.
Results Reference
background
PubMed Identifier
23618662
Citation
Li J, Thompson B, Deng D, Chan LY, Yu M, Hess RF. Dichoptic training enables the adult amblyopic brain to learn. Curr Biol. 2013 Apr 22;23(8):R308-9. doi: 10.1016/j.cub.2013.01.059.
Results Reference
background
PubMed Identifier
21827533
Citation
Lim SJ, Holt LL. Learning foreign sounds in an alien world: videogame training improves non-native speech categorization. Cogn Sci. 2011 Sep-Oct;35(7):1390-405. doi: 10.1111/j.1551-6709.2011.01192.x. Epub 2011 Aug 9.
Results Reference
background
PubMed Identifier
8539603
Citation
Merzenich MM, Jenkins WM, Johnston P, Schreiner C, Miller SL, Tallal P. Temporal processing deficits of language-learning impaired children ameliorated by training. Science. 1996 Jan 5;271(5245):77-81. doi: 10.1126/science.271.5245.77.
Results Reference
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Links:
URL
http://scholar.harvard.edu/polleylab
Description
Laboratory website of Principal Investigator

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Computer-Based Auditory Rehabilitation

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