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Testing Effect and Schizophrenia

Primary Purpose

Schizophrenia, Episodic Memory Deficits

Status
Completed
Phase
Not Applicable
Locations
France
Study Type
Interventional
Intervention
Retrieval practice effect using word pairs and cued recall tests with feedback
Sponsored by
University Hospital, Strasbourg, France
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional supportive care trial for Schizophrenia focused on measuring Schizophrenia, Episodic memory deficits

Eligibility Criteria

18 Years - 60 Years (Adult)All SexesAccepts Healthy Volunteers

Inclusion Criteria:

  • French is the native language, or acquired before 5 years old
  • People must be able to understand and follow the trial instructions

Specific inclusion criteria (for patients) :

  • Diagnostic of schizophrenia, according to the DSM -5, clinically stable
  • The treatment must remain unchanged during the trial

Exclusion Criteria:

  • Severe or acute cerebral disease
  • Other actual psychiatric disorder
  • Use of drugs with high anticholinergic effect
  • Irregular use of benzodiazepines medication, or high dose of benzodiazepin (more than 2 mg of lorazepam per day or equivalent)
  • Inappropriate use of drugs

Specific exclusion criteria (for healthy subjects) :

- Diagnostic of schizophrenia of a relative up to the third degree

Sites / Locations

  • Centre Psychothérapique de Nancy
  • Service de psychiatrie - Hôpital Civil - CHRU Strasbourg

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Active Comparator

Arm Label

Patients with schizophrenia

Healthy subjects

Arm Description

Outcomes

Primary Outcome Measures

Number of word pairs properly recalled
- The aim is to investigate the retrieval practice effect using word pairs and cued recall tests with feedback in patients with schizophrenia and healthy controls. In the first phase (encoding), people study a list of 48 word pairs non semantically associated, then half of the pairs are presented in its completed form for two times, and for the other half the two subsequent re-exposure trials are framed as cued recall tests (the first word is presented and the subject has to remember and give orally the second word, and a feedback is given). In the second phase (final test) which takes place 2 days later, all the 48 word pairs are presented as a cued recall test. - We will compare in patients with schizophrenia and healthy controls final performance recall for information studied and recalled ("test" condition) to those for information studied and then re-studied ("re-study" condition).

Secondary Outcome Measures

Difference between final performance recall and memory span score
In each group (patients with schizophrenia and healthy controls) : Difference between the final performance recall (see primary outcome measure) in "test" condition and "re-study" condition AND memory span score.

Full Information

First Posted
May 26, 2014
Last Updated
October 4, 2017
Sponsor
University Hospital, Strasbourg, France
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1. Study Identification

Unique Protocol Identification Number
NCT02150174
Brief Title
Testing Effect and Schizophrenia
Official Title
Retrieval Practice in Patients With Schizophrenia : an Exploratory Study Using Word Pairs
Study Type
Interventional

2. Study Status

Record Verification Date
September 2017
Overall Recruitment Status
Completed
Study Start Date
July 2014 (Actual)
Primary Completion Date
August 2015 (Actual)
Study Completion Date
August 2015 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
University Hospital, Strasbourg, France

4. Oversight

Data Monitoring Committee
No

5. Study Description

Brief Summary
When people are tested on a previously learned material, they will latter remember it better even when compared to a condition where they can re-study it. This phenomenon is called retrieval practice and is supported by an extensive research literature mostly carried out in normal students. This paradigm begins to be used in cognitive remediation programs in patients suffering from memory difficulties. The objective of this study is to investigate whether retrieval practice is spared in patients with schizophrenia. If effective, this method could be used in cognitive remediation programs. Since episodic memory difficulties are supposed to be secondary to deficits in the initiation/elaboration of efficient encoding and retrieval strategies our hypothesis is that retrieval practice is spared in schizophrenia

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Schizophrenia, Episodic Memory Deficits
Keywords
Schizophrenia, Episodic memory deficits

7. Study Design

Primary Purpose
Supportive Care
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Non-Randomized
Enrollment
40 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Patients with schizophrenia
Arm Type
Experimental
Arm Title
Healthy subjects
Arm Type
Active Comparator
Intervention Type
Behavioral
Intervention Name(s)
Retrieval practice effect using word pairs and cued recall tests with feedback
Intervention Description
In the first phase (encoding), people study a list of 48 word pairs non semantically associated. Then (initial test), they recall half of word pairs or restudy the other half. In the second phase (final test) which takes place 2 days later, they recall all the 48 the word pairs.
Primary Outcome Measure Information:
Title
Number of word pairs properly recalled
Description
- The aim is to investigate the retrieval practice effect using word pairs and cued recall tests with feedback in patients with schizophrenia and healthy controls. In the first phase (encoding), people study a list of 48 word pairs non semantically associated, then half of the pairs are presented in its completed form for two times, and for the other half the two subsequent re-exposure trials are framed as cued recall tests (the first word is presented and the subject has to remember and give orally the second word, and a feedback is given). In the second phase (final test) which takes place 2 days later, all the 48 word pairs are presented as a cued recall test. - We will compare in patients with schizophrenia and healthy controls final performance recall for information studied and recalled ("test" condition) to those for information studied and then re-studied ("re-study" condition).
Time Frame
Final test : 2 days after the first experimental session
Secondary Outcome Measure Information:
Title
Difference between final performance recall and memory span score
Description
In each group (patients with schizophrenia and healthy controls) : Difference between the final performance recall (see primary outcome measure) in "test" condition and "re-study" condition AND memory span score.
Time Frame
Final test : 2 days after the first experimental session

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
60 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: French is the native language, or acquired before 5 years old People must be able to understand and follow the trial instructions Specific inclusion criteria (for patients) : Diagnostic of schizophrenia, according to the DSM -5, clinically stable The treatment must remain unchanged during the trial Exclusion Criteria: Severe or acute cerebral disease Other actual psychiatric disorder Use of drugs with high anticholinergic effect Irregular use of benzodiazepines medication, or high dose of benzodiazepin (more than 2 mg of lorazepam per day or equivalent) Inappropriate use of drugs Specific exclusion criteria (for healthy subjects) : - Diagnostic of schizophrenia of a relative up to the third degree
Facility Information:
Facility Name
Centre Psychothérapique de Nancy
City
Laxou Cedex
ZIP/Postal Code
54521
Country
France
Facility Name
Service de psychiatrie - Hôpital Civil - CHRU Strasbourg
City
Strasbourg
ZIP/Postal Code
67091 Cedex
Country
France

12. IPD Sharing Statement

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Testing Effect and Schizophrenia

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