Controlled-Release Oxycodone Versus Naproxen at Home After Ambulatory Surgery: A Randomized Controlled Trial
Postoperative Pain After Ambulatory Surgery
About this trial
This is an interventional treatment trial for Postoperative Pain After Ambulatory Surgery focused on measuring Postoperative pain, Ambulatory surgery, NSAIDS, CR Oxycodone, Compliance to study medication
Eligibility Criteria
Inclusion Criteria:
- Patients scheduled for painful ambulatory surgery (knee arthroscopy, unilateral open or laparoscopic inguinal hernia repair)
- American Society of Anesthesiologists (ASA) physical classification I or II
Exclusion Criteria:
- cognitive impairment,
- preoperative pharmacologic pain treatment
- allergy to or a contraindication for taking the study medication (e.g. paracetamol, oxycodone, naproxen or another NSAID)
- porphyria
- pregnancy or lactation
- history of severe renal, hepatic, pulmonary, or cardiac failure
- current symptoms or history of gastrointestinal bleeding, ileus or chronic obstipation
- history of substance abuse, or use of medication with a suppressive effect on the central nervous system
Sites / Locations
- Department of Anesthesiology, Maastricht University Medical Center+, The Netherlands
Arms of the Study
Arm 1
Arm 2
Arm 3
No Intervention
Active Comparator
Active Comparator
PCM/NAPR group
PCM/Oxy1 group
PCM/Oxy2 group
paracetamol 1000 mg orally four times a day for 48 hours postoperatively and naproxen 500 mg orally twice a day for 48 hours postoperatively (standard hospital pain protocol for treatment of acute postoperative pain at home after painful day-case surgery)
Controlled Release oxycodone 10 mg orally twice a day for 24 hours and paracetamol 1000 mg orally four times a day for 48 hours postoperatively
CR oxycodone 10 mg orally twice a day for 48 hours and paracetamol 1000 mg orally four times a day for 48 hours postoperatively