Effect of Steroids on Post-Operative Complications Following Proximal Hypospadias Repair
Hypospadias
About this trial
This is an interventional health services research trial for Hypospadias focused on measuring hypospadias
Eligibility Criteria
Inclusion Criteria:
- Patients undergoing proximal hypospadias repair
Exclusion Criteria:
- All patients currently taking steroids at the time of surgery or during the six-week recovery period as well as patients with betamethasone hypersensitivity will be excluded from the study. Selection will be based on parent willingness to allow the child to participate in the study.
Sites / Locations
- Children's Hospital of Pittsburgh of UPMC
Arms of the Study
Arm 1
Arm 2
Active Comparator
Placebo Comparator
oral steroids
placebo-controlled
Systemic high-dose steroids (30 mg/kg methylprednisolone) have been shown in a randomized, double-blind, placebo-controlled trial in humans not to negatively impact wound infection or dehiscence rates, instead benefitting patients in the postoperative period in ways such as decreasing pain. An acute course of oral systemic steroids has been routinely used in patients under the age of 12 with asthma exacerbations (liquid prednisolone at 1-2 mg/kg/day in 1-2 divided doses for up to 10 days, although usually given for 5 days, which is at least 19 times less than the dose proven to be safe in the randomized controlled trial mentioned above) and proven to be safe without adverse effects. Effect of prednisolone on the systemic response and wound healing after colonic surgery.
Simple Syrup will be used as the placebo