Trial of Laparoscopic Cholecystectomy vs. Non-operative Treatment for Gallbladder Dyskinesia
Gallbladder Dyskinesia
About this trial
This is an interventional treatment trial for Gallbladder Dyskinesia
Eligibility Criteria
Inclusion Criteria:
Patients with a normal gallbladder Patients with symptoms compatible with gallbladder dyskinesia (functional gallbladder disorder) as defined by the Rome III criteria Patients with a Cholecystokinin hepatobiliary (CCK-HIDA) scintigraphy gallbladder ejection fraction of <38%, performed at a facility using updated Society of Nuclear Medicaine guidelines for test administration
Exclusion Criteria:
Patients with other known sources of chronic abdominal pain (ex: Crohn's disease) Patients with chronic narcotic use which will affect the reproducibility and validity of the CCK-HIDA results Patient with a history of allergy to amitriptyline Patients with a seizure disorder
Sites / Locations
- Charleston Area Medical CenterRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Laparoscopic cholecystectomy
Non-operative treatment
surgical removal of gallbladder
Administration of amitriptyline 25mg daily, Low Fat-Low Cholesterol Diet