Paradoxical Excitement Response During Sedation Between Dexmedetomidine and Propofol in Hazardous Alcohol Drinker (DEX)
Anesthesia, Spinal, Sedation, Conscious, Dexmedetomidine
About this trial
This is an interventional prevention trial for Anesthesia, Spinal focused on measuring Dexmedetomidine, Sedation, Paradoxical excitement response, Alcohol drinkers
Eligibility Criteria
Inclusion Criteria:
- 19~65 yr-old patients who is scheduled to undergo knee surgery with regional anesthesia
Exclusion Criteria:
- History of taking anxiolytics, hypnotics, antiepileptic drugs
- Abnormal liver function test (eg: Liver cirrhosis, elevated liver enzymes)
- History of allergic reaction with dexmedetomidine or propofol
- Contraindication with regional anesthesia
- American society of anesthesiologist Physical status III or IV
Sites / Locations
- Chonnam National University Hwasun HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Active Comparator
Active Comparator
Active Comparator
alcohol drinker & dexmedetomidine
alcohol drinker & propofol
Non-alcohol drinker & dexmedetomidine
Non-alcohol drinker & propofol
dexmedetomidine, 200mcg in 50mL of normal saline 0.75mcg/Kg bolus injection in 10 minutes 0.1~1.0mcg/Kg infusion during surgery
Propofol (2% fresofol) 25~75mcg/kg/min continuous infusion
dexmedetomidine, 200mcg in 50mL of normal saline 0.75mcg/Kg bolus injection in 10 minutes 0.1~1.0mcg/Kg infusion during surgery
Propofol (2% fresofol) 25~75mcg/kg/min continuous infusion