DMSO for Prevention of Capsular Contraction in Alloplastic Breast Reconstruction
Breast Capsular Contracture, Dimethyl Sulfoxide
About this trial
This is an interventional treatment trial for Breast Capsular Contracture focused on measuring breast capsular contructure, dimethyl sulfoxide, radiotherapy, breast reconstruction
Eligibility Criteria
Inclusion Criteria:
- female candidates for mastectomy, radiotherapy and immediate two-stage reconstruction
Exclusion Criteria:
- autologous reconstruction
- single-stage alloplastic reconstruction
- intake of steroids, anti-inflammatory, anti-coagulate or immunomodulatory medications on a regular basis
- low compliance to home treatment or follow-ups.
Sites / Locations
- Rabin Medical Center
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
DMSO treatment group
the control group
The treatment group will be exposed to DMSO according to our built protocol. On the seventh post-operative day, the patient will be guided to set 10 cc of DMSO soaked gauze compresses on the breast, twice a day for 20 minutes, for the term of 6 weeks. This treatment will be holed for 24 hours on tissue expander inflation dates. A repeated course of compresses will be taken after adjuvant radiotherapy, starting 24 hours after the last therapy.
The control group will be treated with the same post-operative protocol, but with 0.9% saline instead of DMSO. On the seventh post-operative day, the patient will be guided to set 10 cc 0.9% saline soaked gauze compresses on the breast, twice a day for 20 minutes, for the term of 6 weeks. This treatment will be holed for 24 hours on tissue expander inflation dates. A repeated course of compresses will be taken after adjuvant radiotherapy, starting 24 hours after the last therapy.