Ambulosono Rasagiline Musical Walking Study
Parkinson's Disease
About this trial
This is an interventional treatment trial for Parkinson's Disease
Eligibility Criteria
Inclusion Criteria:
- Over 19 years of age
- Confirmed diagnosis of Parkinson's Disease
- Can walk 5 to 10 minutes unassisted
- Have a safe place to walk (outdoor or indoor)
- Have mild to moderate Parkinson's disease (HY1-3)
- Be able to lay flat in the scanner for the period of the study
- No reliance on wheelchair or other walking aid for ambulation
- Absence of any other serious medical conditions such as hearing impairment and dementia
- No history of other neurological and psychiatric illnesses
- No recent musculoskeletal impairment or injuries that may prevent walking
Exclusion Criteria:
- Under 19 years of age
- Unconfirmed PD diagnosis
- Require walking aid, wheelchair-bound
- No access to safe walking pathway
- Severe PD (Hoehn & Yahr stages>3)
- Impaired hearing
- Atypical Parkinsonism
- Concurrent dementia
- Recent knee, hip or foot injury (need permission from doctor)
Exclusion Criteria for fMRI
- Pacemaker
- Brain aneurysm clip
- Cochlear implant
- Recent surgery within the past 6 weeks
- Possibility of pregnancy
- Electrical stimulator for nerves or bones
- Implanted infusion pump
- History of any eye injury involving metal fragments
- History of working with metals (grinding, machining, or welding)
- Artificial heart valve
- Orthopaedic hardware (artificial joint, plate, screws, rods)
- Other metallic prostheses
- Coil, catheter or filter in any blood vessel
- Ear or eye implant
- Recent tattoos within the past 6 weeks
- Shrapnel, bullets, or other metallic fragments
- Medication releasing skin patches (nicotine, birth control, nitroglycerine)
Sites / Locations
- Pacific Parkinson's Research CentreRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Experimental
Experimental
Experimental
Experimental
Experimental
MCW
NCMW
NMW
MCW+rasagiline
MMW+rasagiline
Music Contingent Walking (MCW) group: study-specific musical device that measures gait and plays music in a portable manner as the participant is walking is set at a threshold individually calculated per participant, and the music will stop playing when walking strides fall below this threshold.
Non-contingent Music Walking (NCMW) group: music on all the time regardless of the stride size.
Non-music walking (NMW/silent) group: no music on at all regardless of step size.
Music contingent walking with rasagiline group: same paradigm as the previous MCW, but with rasagiline prescribed as adjunct therapy. Dosage: 0.5 mg/day for the first 2 weeks to be subsequently increased to 1 mg/day
Non-music (silent) walking with rasagiline group: same paradigm as the previous NMW, but with rasagiline prescribed as adjunct therapy. Dosage: 0.5 mg/day for the first 2 weeks to be subsequently increased to 1 mg/day