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Evaluating PCSK9 Binding antiBody Influence oN coGnitive HeAlth in High cardiovascUlar Risk Subjects (EBBINGHAUS)

Primary Purpose

Dyslipidemia

Status
Completed
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Evolocumab
Placebo
Background Statin Therapy
Sponsored by
Amgen
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional other trial for Dyslipidemia focused on measuring High cholesterol, Treatment for high cholesterol, Lowering cholesterol, Lowering high cholesterol, Hypercholesterolemia

Eligibility Criteria

40 Years - 85 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Randomized into Study 20110118 (FOURIER; NCT01764633)

Exclusion Criteria:

  • Current or known past diagnosis of dementia or mild cognitive impairment (MCI)

Sites / Locations

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Arms of the Study

Arm 1

Arm 2

Arm Type

Placebo Comparator

Experimental

Arm Label

Placebo

Evolocumab

Arm Description

Participants received placebo subcutaneous injections either once every 2 weeks (Q2W) or once a month (QM) according to their own preference. Participants continued with their background statin therapy during the course of the study.

Participants received evolocumab 140 mg Q2W or 420 mg QM subcutaneous injections according to their own preference. Participants continued with their background statin therapy during the course of the study.

Outcomes

Primary Outcome Measures

Mean Change From Baseline in Spatial Working Memory Strategy Index of Executive Function (6-8 Boxes) Z Score
Assessments were performed with the Cambridge Neuropsychological Test Automated Battery (CANTAB), a language-independent battery of computerized tests that is used to assess cognitive function. The Spatial Working Memory (SWM) test assesses the cognitive domain of executive function (high-level thinking and decision making). Patients search for colored tokens hidden inside boxes on the screen by touching them. The critical instruction is that once a token has been found inside a box, there will never be a token hidden inside that box again, so patients must not return to a box where a token has been found. The SWM strategy index of executive function represented the number of times a subject began a search with a different box. The Z score represents the standardized measure of how far an individual subject deviates from the study cohort average at baseline. A higher Z score reflects better performance. The mean change from baseline averaged across all the visits is reported.

Secondary Outcome Measures

Mean Change From Baseline in Spatial Working Memory (SWM) Between-errors Z Score
Assessments were performed with the CANTAB, a language-independent battery of computerized tests that is used to assess cognitive function. The Spatial Working Memory (SWM) between-errors test assesses the cognitive domain of working memory (holding material in mind while that material is being actively processed). Patients search for colored tokens hidden inside boxes on the screen by touching them. The critical instruction is that once a token has been found inside a box, there will never be a token hidden inside that box again, so patients must not return to a box where a token has been found. The SWM between-errors score is the number of times that a patient revisited a box in which a token had previously been found. The Z score represents the standardized measure of how far an individual participant deviates from the study cohort average at baseline. A higher Z score reflects better performance. The mean change from baseline averaged across all the visits is reported.
Mean Change From Baseline in Paired Associated Learning (PAL) Total Errors Adjusted Z Score
The CANTAB PAL test assesses visuospatial episodic memory (storing/retrieving information by associating an event with a time and place). Boxes on the screen opened up one at a time to reveal a number of patterns. Participants were asked to remember the location of each pattern. After all the boxes had been opened, each pattern was then shown in the center of the screen in a randomized order, and the patient should touch the box where they think each pattern was hidden. The PAL total errors adjusted comprised the number of errors committed by a patient plus an adjustment for the estimated number of errors the patient would have made on any stages that were not reached. Z score represents the standardized measure of how far an individual patient deviates from the study cohort average at baseline. A higher Z score indicated better performance. The mean change from baseline averaged across all the visits is reported.
Mean Change From Baseline in Reaction Time (RTI) Median 5-choice Reaction Time Z Score
Assessments were performed with the CANTAB, a language-independent battery of computerized tests that is used to assess cognitive function. The Reaction Time (RTI) test assessed the cognitive domain of psychomotor speed (detecting and responding to a stimulus). Participants held down a button until a spot appeared in 1 of 5 circles on the screen. As soon as possible after the spot flashed up, the patient lifted their finger from the button and touched the circle in which the spot appeared. The RTI median 5-choice reaction time was the median duration between the onset of the stimulus and the release of the button. Z score represents the standardized measure of how far an individual participant deviates from the study cohort average at baseline. A higher Z score reflects better performance. The mean change from baseline averaged across all the visits is reported.

Full Information

First Posted
July 31, 2014
Last Updated
December 15, 2017
Sponsor
Amgen
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1. Study Identification

Unique Protocol Identification Number
NCT02207634
Brief Title
Evaluating PCSK9 Binding antiBody Influence oN coGnitive HeAlth in High cardiovascUlar Risk Subjects
Acronym
EBBINGHAUS
Official Title
A Double-Blind, Placebo Controlled, Multicenter Study to Assess the Effect of Evolocumab on Cognitive Function in Patients With Clinically Evident Cardiovascular Disease and Receiving Statin Background Lipid Lowering Therapy: A Study for Subjects Enrolled in the FOURIER (Study 20110118) Trial
Study Type
Interventional

2. Study Status

Record Verification Date
December 2017
Overall Recruitment Status
Completed
Study Start Date
September 10, 2014 (Actual)
Primary Completion Date
November 11, 2016 (Actual)
Study Completion Date
November 11, 2016 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Amgen

4. Oversight

Data Monitoring Committee
Yes

5. Study Description

Brief Summary
This study evaluated change over time in neurocognitive testing in patients receiving statin therapy in combination with evolocumab (AMG 145), compared with patients receiving statin therapy in combination with placebo.
Detailed Description
Participants who were enrolled in study 20110118 (FOURIER; NCT01764633) at select sites in select countries (selected based on study start-up timelines) were invited to participate in this cognitive function study, 20130385. There was no separate randomization for Study 20130385; data were analyzed according to Study 20110118 randomized treatment arm.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Dyslipidemia
Keywords
High cholesterol, Treatment for high cholesterol, Lowering cholesterol, Lowering high cholesterol, Hypercholesterolemia

7. Study Design

Primary Purpose
Other
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantCare ProviderInvestigatorOutcomes Assessor
Allocation
Randomized
Enrollment
1974 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Placebo
Arm Type
Placebo Comparator
Arm Description
Participants received placebo subcutaneous injections either once every 2 weeks (Q2W) or once a month (QM) according to their own preference. Participants continued with their background statin therapy during the course of the study.
Arm Title
Evolocumab
Arm Type
Experimental
Arm Description
Participants received evolocumab 140 mg Q2W or 420 mg QM subcutaneous injections according to their own preference. Participants continued with their background statin therapy during the course of the study.
Intervention Type
Biological
Intervention Name(s)
Evolocumab
Other Intervention Name(s)
AMG 145, Repatha
Intervention Description
Administered subcutaneously using a spring-based prefilled 1.0 mL autoinjector/pen.
Intervention Type
Drug
Intervention Name(s)
Placebo
Intervention Description
Administered subcutaneously using a spring-based prefilled 1.0 mL autoinjector/pen.
Intervention Type
Drug
Intervention Name(s)
Background Statin Therapy
Intervention Description
Participants were required to be on a stable, high- to moderate-intensity statin background therapy consisting of an effective statin dose, ie, at least atorvastatin 20 mg daily or equivalent, and where locally approved, highly effective statin therapy (defined as at least atorvastatin 40 mg daily or equivalent) was recommended.
Primary Outcome Measure Information:
Title
Mean Change From Baseline in Spatial Working Memory Strategy Index of Executive Function (6-8 Boxes) Z Score
Description
Assessments were performed with the Cambridge Neuropsychological Test Automated Battery (CANTAB), a language-independent battery of computerized tests that is used to assess cognitive function. The Spatial Working Memory (SWM) test assesses the cognitive domain of executive function (high-level thinking and decision making). Patients search for colored tokens hidden inside boxes on the screen by touching them. The critical instruction is that once a token has been found inside a box, there will never be a token hidden inside that box again, so patients must not return to a box where a token has been found. The SWM strategy index of executive function represented the number of times a subject began a search with a different box. The Z score represents the standardized measure of how far an individual subject deviates from the study cohort average at baseline. A higher Z score reflects better performance. The mean change from baseline averaged across all the visits is reported.
Time Frame
Assessments were conducted at Baseline and at weeks 24, 48, 96, 144 and end of study visit (median time on study was 19.4 months).
Secondary Outcome Measure Information:
Title
Mean Change From Baseline in Spatial Working Memory (SWM) Between-errors Z Score
Description
Assessments were performed with the CANTAB, a language-independent battery of computerized tests that is used to assess cognitive function. The Spatial Working Memory (SWM) between-errors test assesses the cognitive domain of working memory (holding material in mind while that material is being actively processed). Patients search for colored tokens hidden inside boxes on the screen by touching them. The critical instruction is that once a token has been found inside a box, there will never be a token hidden inside that box again, so patients must not return to a box where a token has been found. The SWM between-errors score is the number of times that a patient revisited a box in which a token had previously been found. The Z score represents the standardized measure of how far an individual participant deviates from the study cohort average at baseline. A higher Z score reflects better performance. The mean change from baseline averaged across all the visits is reported.
Time Frame
Assessments were conducted at Baseline and at weeks 24, 48, 96, 144 and end of study visit (median time on study was 19.4 months).
Title
Mean Change From Baseline in Paired Associated Learning (PAL) Total Errors Adjusted Z Score
Description
The CANTAB PAL test assesses visuospatial episodic memory (storing/retrieving information by associating an event with a time and place). Boxes on the screen opened up one at a time to reveal a number of patterns. Participants were asked to remember the location of each pattern. After all the boxes had been opened, each pattern was then shown in the center of the screen in a randomized order, and the patient should touch the box where they think each pattern was hidden. The PAL total errors adjusted comprised the number of errors committed by a patient plus an adjustment for the estimated number of errors the patient would have made on any stages that were not reached. Z score represents the standardized measure of how far an individual patient deviates from the study cohort average at baseline. A higher Z score indicated better performance. The mean change from baseline averaged across all the visits is reported.
Time Frame
Assessments were conducted at Baseline and at weeks 24, 48, 96, 144 and end of study visit (median time on study was 19.4 months).
Title
Mean Change From Baseline in Reaction Time (RTI) Median 5-choice Reaction Time Z Score
Description
Assessments were performed with the CANTAB, a language-independent battery of computerized tests that is used to assess cognitive function. The Reaction Time (RTI) test assessed the cognitive domain of psychomotor speed (detecting and responding to a stimulus). Participants held down a button until a spot appeared in 1 of 5 circles on the screen. As soon as possible after the spot flashed up, the patient lifted their finger from the button and touched the circle in which the spot appeared. The RTI median 5-choice reaction time was the median duration between the onset of the stimulus and the release of the button. Z score represents the standardized measure of how far an individual participant deviates from the study cohort average at baseline. A higher Z score reflects better performance. The mean change from baseline averaged across all the visits is reported.
Time Frame
Assessments were conducted at Baseline and at weeks 24, 48, 96, 144 and end of study visit (median time on study was 19.4 months).

10. Eligibility

Sex
All
Minimum Age & Unit of Time
40 Years
Maximum Age & Unit of Time
85 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Randomized into Study 20110118 (FOURIER; NCT01764633) Exclusion Criteria: Current or known past diagnosis of dementia or mild cognitive impairment (MCI)
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
MD
Organizational Affiliation
Amgen
Official's Role
Study Director
Facility Information:
Facility Name
Research Site
City
Birmingham
State/Province
Alabama
ZIP/Postal Code
35294
Country
United States
Facility Name
Research Site
City
Huntsville
State/Province
Alabama
ZIP/Postal Code
35801
Country
United States
Facility Name
Research Site
City
Mobile
State/Province
Alabama
ZIP/Postal Code
36608
Country
United States
Facility Name
Research Site
City
Glendale
State/Province
Arizona
ZIP/Postal Code
85306
Country
United States
Facility Name
Research Site
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85018
Country
United States
Facility Name
Research Site
City
Alhambra
State/Province
California
ZIP/Postal Code
91801
Country
United States
Facility Name
Research Site
City
Banning
State/Province
California
ZIP/Postal Code
92220
Country
United States
Facility Name
Research Site
City
Harbor City
State/Province
California
ZIP/Postal Code
90710
Country
United States
Facility Name
Research Site
City
Laguna Hills
State/Province
California
ZIP/Postal Code
92653
Country
United States
Facility Name
Research Site
City
Long Beach
State/Province
California
ZIP/Postal Code
90807
Country
United States
Facility Name
Research Site
City
Long Beach
State/Province
California
ZIP/Postal Code
90822
Country
United States
Facility Name
Research Site
City
Oceanside
State/Province
California
ZIP/Postal Code
92056
Country
United States
Facility Name
Research Site
City
Oxnard
State/Province
California
ZIP/Postal Code
93030
Country
United States
Facility Name
Research Site
City
Palm Springs
State/Province
California
ZIP/Postal Code
92262
Country
United States
Facility Name
Research Site
City
Roseville
State/Province
California
ZIP/Postal Code
95661
Country
United States
Facility Name
Research Site
City
Sacramento
State/Province
California
ZIP/Postal Code
95816
Country
United States
Facility Name
Research Site
City
San Pedro
State/Province
California
ZIP/Postal Code
90732
Country
United States
Facility Name
Research Site
City
Tarzana
State/Province
California
ZIP/Postal Code
91356
Country
United States
Facility Name
Research Site
City
Thousand Oaks
State/Province
California
ZIP/Postal Code
91360
Country
United States
Facility Name
Research Site
City
Aurora
State/Province
Colorado
ZIP/Postal Code
80012
Country
United States
Facility Name
Research Site
City
Colorado Springs
State/Province
Colorado
ZIP/Postal Code
80909
Country
United States
Facility Name
Research Site
City
Denver
State/Province
Colorado
ZIP/Postal Code
80218
Country
United States
Facility Name
Research Site
City
Bridgeport
State/Province
Connecticut
ZIP/Postal Code
06610
Country
United States
Facility Name
Research Site
City
Boynton Beach
State/Province
Florida
ZIP/Postal Code
33472
Country
United States
Facility Name
Research Site
City
Crystal River
State/Province
Florida
ZIP/Postal Code
34429
Country
United States
Facility Name
Research Site
City
Daytona Beach
State/Province
Florida
ZIP/Postal Code
32117
Country
United States
Facility Name
Research Site
City
Deerfield Beach
State/Province
Florida
ZIP/Postal Code
33442
Country
United States
Facility Name
Research Site
City
Fleming Island
State/Province
Florida
ZIP/Postal Code
32003
Country
United States
Facility Name
Research Site
City
Hollywood
State/Province
Florida
ZIP/Postal Code
33021
Country
United States
Facility Name
Research Site
City
Hollywood
State/Province
Florida
ZIP/Postal Code
33024
Country
United States
Facility Name
Research Site
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32216
Country
United States
Facility Name
Research Site
City
Miami
State/Province
Florida
ZIP/Postal Code
33144
Country
United States
Facility Name
Research Site
City
Palm Harbor
State/Province
Florida
ZIP/Postal Code
34684
Country
United States
Facility Name
Research Site
City
Pembroke Pines
State/Province
Florida
ZIP/Postal Code
33025
Country
United States
Facility Name
Research Site
City
Ponte Vedra
State/Province
Florida
ZIP/Postal Code
32081
Country
United States
Facility Name
Research Site
City
Saint Petersburg
State/Province
Florida
ZIP/Postal Code
33713
Country
United States
Facility Name
Research Site
City
Sarasota
State/Province
Florida
ZIP/Postal Code
34232
Country
United States
Facility Name
Research Site
City
Tampa
State/Province
Florida
ZIP/Postal Code
33614
Country
United States
Facility Name
Research Site
City
West Palm Beach
State/Province
Florida
ZIP/Postal Code
33401
Country
United States
Facility Name
Research Site
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30342
Country
United States
Facility Name
Research Site
City
Augusta
State/Province
Georgia
ZIP/Postal Code
30909
Country
United States
Facility Name
Research Site
City
Gainesville
State/Province
Georgia
ZIP/Postal Code
30501
Country
United States
Facility Name
Research Site
City
Savannah
State/Province
Georgia
ZIP/Postal Code
31406
Country
United States
Facility Name
Research Site
City
Suwanee
State/Province
Georgia
ZIP/Postal Code
30024
Country
United States
Facility Name
Research Site
City
Coeur d'Alene
State/Province
Idaho
ZIP/Postal Code
83814
Country
United States
Facility Name
Research Site
City
Addison
State/Province
Illinois
ZIP/Postal Code
60101
Country
United States
Facility Name
Research Site
City
Belleville
State/Province
Illinois
ZIP/Postal Code
62220
Country
United States
Facility Name
Research Site
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60616
Country
United States
Facility Name
Research Site
City
Jerseyville
State/Province
Illinois
ZIP/Postal Code
62052
Country
United States
Facility Name
Research Site
City
Hammond
State/Province
Indiana
ZIP/Postal Code
46320
Country
United States
Facility Name
Research Site
City
Waterloo
State/Province
Iowa
ZIP/Postal Code
50702
Country
United States
Facility Name
Research Site
City
Hutchinson
State/Province
Kansas
ZIP/Postal Code
67502
Country
United States
Facility Name
Research Site
City
Lexington
State/Province
Kentucky
ZIP/Postal Code
40503
Country
United States
Facility Name
Research Site
City
Owensboro
State/Province
Kentucky
ZIP/Postal Code
42303
Country
United States
Facility Name
Research Site
City
Baton Rouge
State/Province
Louisiana
ZIP/Postal Code
70808
Country
United States
Facility Name
Research Site
City
Hammond
State/Province
Louisiana
ZIP/Postal Code
70403
Country
United States
Facility Name
Research Site
City
Lafayette
State/Province
Louisiana
ZIP/Postal Code
70508
Country
United States
Facility Name
Research Site
City
Metairie
State/Province
Louisiana
ZIP/Postal Code
70006
Country
United States
Facility Name
Research Site
City
Monroe
State/Province
Louisiana
ZIP/Postal Code
71201
Country
United States
Facility Name
Research Site
City
Slidell
State/Province
Louisiana
ZIP/Postal Code
70458
Country
United States
Facility Name
Research Site
City
Biddeford
State/Province
Maine
ZIP/Postal Code
04005
Country
United States
Facility Name
Research Site
City
Salisbury
State/Province
Maryland
ZIP/Postal Code
21804
Country
United States
Facility Name
Research Site
City
Towson
State/Province
Maryland
ZIP/Postal Code
21204
Country
United States
Facility Name
Research Site
City
Haverhill
State/Province
Massachusetts
ZIP/Postal Code
01830
Country
United States
Facility Name
Research Site
City
Newton
State/Province
Massachusetts
ZIP/Postal Code
02459
Country
United States
Facility Name
Research Site
City
Ann Arbor
State/Province
Michigan
ZIP/Postal Code
48106
Country
United States
Facility Name
Research Site
City
Grandville
State/Province
Michigan
ZIP/Postal Code
49418
Country
United States
Facility Name
Research Site
City
Lansing
State/Province
Michigan
ZIP/Postal Code
48912
Country
United States
Facility Name
Research Site
City
Muskegon
State/Province
Michigan
ZIP/Postal Code
49444
Country
United States
Facility Name
Research Site
City
Saint Paul
State/Province
Minnesota
ZIP/Postal Code
55102
Country
United States
Facility Name
Research Site
City
Jefferson City
State/Province
Missouri
ZIP/Postal Code
65109
Country
United States
Facility Name
Research Site
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63117
Country
United States
Facility Name
Research Site
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63128
Country
United States
Facility Name
Research Site
City
Great Falls
State/Province
Montana
ZIP/Postal Code
59405
Country
United States
Facility Name
Research Site
City
Kalispell
State/Province
Montana
ZIP/Postal Code
59901
Country
United States
Facility Name
Research Site
City
Voorhees
State/Province
New Jersey
ZIP/Postal Code
08043
Country
United States
Facility Name
Research Site
City
Westwood
State/Province
New Jersey
ZIP/Postal Code
07675
Country
United States
Facility Name
Research Site
City
Brooklyn
State/Province
New York
ZIP/Postal Code
11206
Country
United States
Facility Name
Research Site
City
Buffalo
State/Province
New York
ZIP/Postal Code
14215
Country
United States
Facility Name
Research Site
City
Cortlandt Manor
State/Province
New York
ZIP/Postal Code
10567
Country
United States
Facility Name
Research Site
City
New Hyde Park
State/Province
New York
ZIP/Postal Code
11042
Country
United States
Facility Name
Research Site
City
New Windsor
State/Province
New York
ZIP/Postal Code
12553
Country
United States
Facility Name
Research Site
City
Rochester
State/Province
New York
ZIP/Postal Code
14609
Country
United States
Facility Name
Research Site
City
Troy
State/Province
New York
ZIP/Postal Code
12180
Country
United States
Facility Name
Research Site
City
West Seneca
State/Province
New York
ZIP/Postal Code
14224
Country
United States
Facility Name
Research Site
City
Williamsville
State/Province
New York
ZIP/Postal Code
14221
Country
United States
Facility Name
Research Site
City
Calabash
State/Province
North Carolina
ZIP/Postal Code
28467
Country
United States
Facility Name
Research Site
City
Hickory
State/Province
North Carolina
ZIP/Postal Code
28601
Country
United States
Facility Name
Research Site
City
Hickory
State/Province
North Carolina
ZIP/Postal Code
28602
Country
United States
Facility Name
Research Site
City
Mooresville
State/Province
North Carolina
ZIP/Postal Code
28117
Country
United States
Facility Name
Research Site
City
Raleigh
State/Province
North Carolina
ZIP/Postal Code
27609
Country
United States
Facility Name
Research Site
City
Tabor City
State/Province
North Carolina
ZIP/Postal Code
28463
Country
United States
Facility Name
Research Site
City
Winston-Salem
State/Province
North Carolina
ZIP/Postal Code
27103
Country
United States
Facility Name
Research Site
City
Grand Forks
State/Province
North Dakota
ZIP/Postal Code
58201
Country
United States
Facility Name
Research Site
City
Canton
State/Province
Ohio
ZIP/Postal Code
44708
Country
United States
Facility Name
Research Site
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45219
Country
United States
Facility Name
Research Site
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43201
Country
United States
Facility Name
Research Site
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43215
Country
United States
Facility Name
Research Site
City
Dayton
State/Province
Ohio
ZIP/Postal Code
45414
Country
United States
Facility Name
Research Site
City
Springfield
State/Province
Ohio
ZIP/Postal Code
45505
Country
United States
Facility Name
Research Site
City
Toledo
State/Province
Ohio
ZIP/Postal Code
43615
Country
United States
Facility Name
Research Site
City
Pryor
State/Province
Oklahoma
ZIP/Postal Code
74362
Country
United States
Facility Name
Research Site
City
Bend
State/Province
Oregon
ZIP/Postal Code
97701
Country
United States
Facility Name
Research Site
City
Portland
State/Province
Oregon
ZIP/Postal Code
97225
Country
United States
Facility Name
Research Site
City
Portland
State/Province
Oregon
ZIP/Postal Code
97239
Country
United States
Facility Name
Research Site
City
Camp Hill
State/Province
Pennsylvania
ZIP/Postal Code
17011
Country
United States
Facility Name
Research Site
City
Chambersburg
State/Province
Pennsylvania
ZIP/Postal Code
17201
Country
United States
Facility Name
Research Site
City
Feasterville
State/Province
Pennsylvania
ZIP/Postal Code
19053
Country
United States
Facility Name
Research Site
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19152
Country
United States
Facility Name
Research Site
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15206
Country
United States
Facility Name
Research Site
City
Pawtucket
State/Province
Rhode Island
ZIP/Postal Code
02860
Country
United States
Facility Name
Research Site
City
Fort Mill
State/Province
South Carolina
ZIP/Postal Code
29707
Country
United States
Facility Name
Research Site
City
Moncks Corner
State/Province
South Carolina
ZIP/Postal Code
29461
Country
United States
Facility Name
Research Site
City
Mount Pleasant
State/Province
South Carolina
ZIP/Postal Code
29464
Country
United States
Facility Name
Research Site
City
North Myrtle Beach
State/Province
South Carolina
ZIP/Postal Code
29582
Country
United States
Facility Name
Research Site
City
Rapid City
State/Province
South Dakota
ZIP/Postal Code
57701
Country
United States
Facility Name
Research Site
City
Jackson
State/Province
Tennessee
ZIP/Postal Code
38305
Country
United States
Facility Name
Research Site
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37203
Country
United States
Facility Name
Research Site
City
Tullahoma
State/Province
Tennessee
ZIP/Postal Code
37388
Country
United States
Facility Name
Research Site
City
Austin
State/Province
Texas
ZIP/Postal Code
78758
Country
United States
Facility Name
Research Site
City
Dallas
State/Province
Texas
ZIP/Postal Code
75216
Country
United States
Facility Name
Research Site
City
Houston
State/Province
Texas
ZIP/Postal Code
77025
Country
United States
Facility Name
Research Site
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
Research Site
City
Plano
State/Province
Texas
ZIP/Postal Code
75024
Country
United States
Facility Name
Research Site
City
Wichita Falls
State/Province
Texas
ZIP/Postal Code
76301
Country
United States
Facility Name
Research Site
City
West Jordan
State/Province
Utah
ZIP/Postal Code
84088
Country
United States
Facility Name
Research Site
City
Burke
State/Province
Virginia
ZIP/Postal Code
22015
Country
United States
Facility Name
Research Site
City
Falls Church
State/Province
Virginia
ZIP/Postal Code
22042
Country
United States
Facility Name
Research Site
City
Hopewell
State/Province
Virginia
ZIP/Postal Code
23860
Country
United States
Facility Name
Research Site
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23219
Country
United States
Facility Name
Research Site
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23294
Country
United States
Facility Name
Research Site
City
Suffolk
State/Province
Virginia
ZIP/Postal Code
23435
Country
United States
Facility Name
Research Site
City
Seattle
State/Province
Washington
ZIP/Postal Code
98195
Country
United States
Facility Name
Research Site
City
Green Bay
State/Province
Wisconsin
ZIP/Postal Code
54301
Country
United States
Facility Name
Research Site
City
Woden
State/Province
Australian Capital Territory
ZIP/Postal Code
2605
Country
Australia
Facility Name
Research Site
City
Auchenflower
State/Province
Queensland
ZIP/Postal Code
4066
Country
Australia
Facility Name
Research Site
City
Adelaide
State/Province
South Australia
ZIP/Postal Code
5000
Country
Australia
Facility Name
Research Site
City
Ashford
State/Province
South Australia
ZIP/Postal Code
5035
Country
Australia
Facility Name
Research Site
City
Fullarton
State/Province
South Australia
ZIP/Postal Code
5063
Country
Australia
Facility Name
Research Site
City
Hobart
State/Province
Tasmania
ZIP/Postal Code
7000
Country
Australia
Facility Name
Research Site
City
Box Hill
State/Province
Victoria
ZIP/Postal Code
3128
Country
Australia
Facility Name
Research Site
City
Epping
State/Province
Victoria
ZIP/Postal Code
3076
Country
Australia
Facility Name
Research Site
City
Geelong
State/Province
Victoria
ZIP/Postal Code
3220
Country
Australia
Facility Name
Research Site
City
Aalst
ZIP/Postal Code
9300
Country
Belgium
Facility Name
Research Site
City
Bonheiden
ZIP/Postal Code
2820
Country
Belgium
Facility Name
Research Site
City
Brussels
ZIP/Postal Code
1020
Country
Belgium
Facility Name
Research Site
City
Brussels
ZIP/Postal Code
1070
Country
Belgium
Facility Name
Research Site
City
Gozee
ZIP/Postal Code
6534
Country
Belgium
Facility Name
Research Site
City
Ieper
ZIP/Postal Code
8900
Country
Belgium
Facility Name
Research Site
City
La Louvière
ZIP/Postal Code
7100
Country
Belgium
Facility Name
Research Site
City
Liege
ZIP/Postal Code
4000
Country
Belgium
Facility Name
Research Site
City
Liège
ZIP/Postal Code
4000
Country
Belgium
Facility Name
Research Site
City
St. Johns
State/Province
Newfoundland and Labrador
ZIP/Postal Code
A1B 3V6
Country
Canada
Facility Name
Research Site
City
London
State/Province
Ontario
ZIP/Postal Code
N6C 0A7
Country
Canada
Facility Name
Research Site
City
Newmarket
State/Province
Ontario
ZIP/Postal Code
L3Y 5G8
Country
Canada
Facility Name
Research Site
City
Newmarket
State/Province
Ontario
ZIP/Postal Code
L3Y 8C3
Country
Canada
Facility Name
Research Site
City
Peterborough
State/Province
Ontario
ZIP/Postal Code
K9J 0B2
Country
Canada
Facility Name
Research Site
City
Sarnia
State/Province
Ontario
ZIP/Postal Code
N7T 4X3
Country
Canada
Facility Name
Research Site
City
Chicoutimi
State/Province
Quebec
ZIP/Postal Code
G7H 7K9
Country
Canada
Facility Name
Research Site
City
Gatineau
State/Province
Quebec
ZIP/Postal Code
J8Y 6S8
Country
Canada
Facility Name
Research Site
City
Pointe-Claire
State/Province
Quebec
ZIP/Postal Code
H9R 3J1
Country
Canada
Facility Name
Research Site
City
St Jean sur Richelieu
State/Province
Quebec
ZIP/Postal Code
J3A 1C3
Country
Canada
Facility Name
Research Site
City
St-Jérôme
State/Province
Quebec
ZIP/Postal Code
J7Z 5T3
Country
Canada
Facility Name
Research Site
City
Quebec
ZIP/Postal Code
G1V 4M6
Country
Canada
Facility Name
Research Site
City
Beroun
ZIP/Postal Code
266 01
Country
Czechia
Facility Name
Research Site
City
Bilovec
ZIP/Postal Code
743 01
Country
Czechia
Facility Name
Research Site
City
Brandys nad Labem
ZIP/Postal Code
250 01
Country
Czechia
Facility Name
Research Site
City
Brno
ZIP/Postal Code
602 00
Country
Czechia
Facility Name
Research Site
City
Brno
ZIP/Postal Code
636 00
Country
Czechia
Facility Name
Research Site
City
Brno
ZIP/Postal Code
638 00
Country
Czechia
Facility Name
Research Site
City
Chomutov
ZIP/Postal Code
430 02
Country
Czechia
Facility Name
Research Site
City
Havlickuv Brod
ZIP/Postal Code
580 22
Country
Czechia
Facility Name
Research Site
City
Hodonin
ZIP/Postal Code
695 01
Country
Czechia
Facility Name
Research Site
City
Klatovy IV
ZIP/Postal Code
339 01
Country
Czechia
Facility Name
Research Site
City
Liberec
ZIP/Postal Code
460 63
Country
Czechia
Facility Name
Research Site
City
Litomysl
ZIP/Postal Code
570 14
Country
Czechia
Facility Name
Research Site
City
Mohelnice
ZIP/Postal Code
789 85
Country
Czechia
Facility Name
Research Site
City
Olomouc
ZIP/Postal Code
779 00
Country
Czechia
Facility Name
Research Site
City
Ostrava - Vitkovice
ZIP/Postal Code
703 00
Country
Czechia
Facility Name
Research Site
City
Pardubice
ZIP/Postal Code
530 02
Country
Czechia
Facility Name
Research Site
City
Praha 10
ZIP/Postal Code
101 00
Country
Czechia
Facility Name
Research Site
City
Praha 2
ZIP/Postal Code
128 08
Country
Czechia
Facility Name
Research Site
City
Praha 3
ZIP/Postal Code
130 00
Country
Czechia
Facility Name
Research Site
City
Praha 4
ZIP/Postal Code
140 21
Country
Czechia
Facility Name
Research Site
City
Praha 5 - Smichov
ZIP/Postal Code
150 00
Country
Czechia
Facility Name
Research Site
City
Prerov
ZIP/Postal Code
750 02
Country
Czechia
Facility Name
Research Site
City
Uherske Hradiste
ZIP/Postal Code
686 01
Country
Czechia
Facility Name
Research Site
City
Aalborg
ZIP/Postal Code
9000
Country
Denmark
Facility Name
Research Site
City
Ballerup
ZIP/Postal Code
2750
Country
Denmark
Facility Name
Research Site
City
Esbjerg
ZIP/Postal Code
6700
Country
Denmark
Facility Name
Research Site
City
Hvidovre
ZIP/Postal Code
2650
Country
Denmark
Facility Name
Research Site
City
København S
ZIP/Postal Code
2300
Country
Denmark
Facility Name
Research Site
City
Køge
ZIP/Postal Code
4600
Country
Denmark
Facility Name
Research Site
City
Vejle
ZIP/Postal Code
7100
Country
Denmark
Facility Name
Research Site
City
Paide
ZIP/Postal Code
72713
Country
Estonia
Facility Name
Research Site
City
Tallinn
ZIP/Postal Code
10128
Country
Estonia
Facility Name
Research Site
City
Tallinn
ZIP/Postal Code
10138
Country
Estonia
Facility Name
Research Site
City
Tallinn
ZIP/Postal Code
13419
Country
Estonia
Facility Name
Research Site
City
Helsinki
ZIP/Postal Code
00180
Country
Finland
Facility Name
Research Site
City
Helsinki
ZIP/Postal Code
00290
Country
Finland
Facility Name
Research Site
City
Jyväskylä
ZIP/Postal Code
40100
Country
Finland
Facility Name
Research Site
City
Kuopio
ZIP/Postal Code
70100
Country
Finland
Facility Name
Research Site
City
Oulu
ZIP/Postal Code
90100
Country
Finland
Facility Name
Research Site
City
OYS
ZIP/Postal Code
90029
Country
Finland
Facility Name
Research Site
City
Tampere
ZIP/Postal Code
33100
Country
Finland
Facility Name
Research Site
City
Turku
ZIP/Postal Code
20100
Country
Finland
Facility Name
Research Site
City
Besançon Cedex
ZIP/Postal Code
25030
Country
France
Facility Name
Research Site
City
Le Coudray
ZIP/Postal Code
28630
Country
France
Facility Name
Research Site
City
Montepellier Cedex
ZIP/Postal Code
34295
Country
France
Facility Name
Research Site
City
Nantes Cedex 1
ZIP/Postal Code
44093
Country
France
Facility Name
Research Site
City
Paris
ZIP/Postal Code
75013
Country
France
Facility Name
Research Site
City
Pessac Cedex
ZIP/Postal Code
33604
Country
France
Facility Name
Research Site
City
Toulouse Cedex 9
ZIP/Postal Code
31059
Country
France
Facility Name
Research Site
City
Bad Krozingen
ZIP/Postal Code
79189
Country
Germany
Facility Name
Research Site
City
Berlin
ZIP/Postal Code
10787
Country
Germany
Facility Name
Research Site
City
Berlin
ZIP/Postal Code
12559
Country
Germany
Facility Name
Research Site
City
Berlin
ZIP/Postal Code
13353
Country
Germany
Facility Name
Research Site
City
Bochum
ZIP/Postal Code
44787
Country
Germany
Facility Name
Research Site
City
Dresden
ZIP/Postal Code
01307
Country
Germany
Facility Name
Research Site
City
Frankfurt am Main
ZIP/Postal Code
60596
Country
Germany
Facility Name
Research Site
City
Hamburg
ZIP/Postal Code
20246
Country
Germany
Facility Name
Research Site
City
Hannover
ZIP/Postal Code
30159
Country
Germany
Facility Name
Research Site
City
Köln
ZIP/Postal Code
50937
Country
Germany
Facility Name
Research Site
City
Leipzig
ZIP/Postal Code
04103
Country
Germany
Facility Name
Research Site
City
Stuttgart
ZIP/Postal Code
70376
Country
Germany
Facility Name
Research Site
City
Witten
ZIP/Postal Code
58455
Country
Germany
Facility Name
Research Site
City
Wuppertal
ZIP/Postal Code
42117
Country
Germany
Facility Name
Research Site
City
Alexandroupoli
ZIP/Postal Code
68100
Country
Greece
Facility Name
Research Site
City
Athens
ZIP/Postal Code
11521
Country
Greece
Facility Name
Research Site
City
Athens
ZIP/Postal Code
14233
Country
Greece
Facility Name
Research Site
City
Athens
ZIP/Postal Code
14561
Country
Greece
Facility Name
Research Site
City
Ioannina
ZIP/Postal Code
45500
Country
Greece
Facility Name
Research Site
City
Larissa
ZIP/Postal Code
41110
Country
Greece
Facility Name
Research Site
City
Piraeus
ZIP/Postal Code
18536
Country
Greece
Facility Name
Research Site
City
Hong Kong
Country
Hong Kong
Facility Name
Research Site
City
Bekescsaba
ZIP/Postal Code
5600
Country
Hungary
Facility Name
Research Site
City
Berettyoujfalu
ZIP/Postal Code
4100
Country
Hungary
Facility Name
Research Site
City
Budapest
ZIP/Postal Code
1036
Country
Hungary
Facility Name
Research Site
City
Nyiregyhaza
ZIP/Postal Code
4400
Country
Hungary
Facility Name
Research Site
City
Pecs
ZIP/Postal Code
7624
Country
Hungary
Facility Name
Research Site
City
Szeged
ZIP/Postal Code
6725
Country
Hungary
Facility Name
Research Site
City
Szekszard
ZIP/Postal Code
7100
Country
Hungary
Facility Name
Research Site
City
Szikszo
ZIP/Postal Code
3800
Country
Hungary
Facility Name
Research Site
City
Zalaegerszeg
ZIP/Postal Code
8900
Country
Hungary
Facility Name
Research Site
City
Pavia
ZIP/Postal Code
27100
Country
Italy
Facility Name
Research Site
City
Ichinomiya-shi
State/Province
Aichi
ZIP/Postal Code
491-8551
Country
Japan
Facility Name
Research Site
City
Kasugai-shi
State/Province
Aichi
ZIP/Postal Code
487-0031
Country
Japan
Facility Name
Research Site
City
Nagoya-shi
State/Province
Aichi
ZIP/Postal Code
451-8511
Country
Japan
Facility Name
Research Site
City
Nagoya-shi
State/Province
Aichi
ZIP/Postal Code
457-8511
Country
Japan
Facility Name
Research Site
City
Nagoya-shi
State/Province
Aichi
ZIP/Postal Code
460-0001
Country
Japan
Facility Name
Research Site
City
Toyohashi-shi
State/Province
Aichi
ZIP/Postal Code
440-8510
Country
Japan
Facility Name
Research Site
City
Matsudo-shi
State/Province
Chiba
ZIP/Postal Code
271-0077
Country
Japan
Facility Name
Research Site
City
Saijo-shi
State/Province
Ehime
ZIP/Postal Code
793-0030
Country
Japan
Facility Name
Research Site
City
Chikushi-gun
State/Province
Fukuoka
ZIP/Postal Code
811-1244
Country
Japan
Facility Name
Research Site
City
Fukuoka-shi
State/Province
Fukuoka
ZIP/Postal Code
814-0180
Country
Japan
Facility Name
Research Site
City
Fukuoka-shi
State/Province
Fukuoka
ZIP/Postal Code
814-8522
Country
Japan
Facility Name
Research Site
City
Itoshima-shi
State/Province
Fukuoka
ZIP/Postal Code
819-1104
Country
Japan
Facility Name
Research Site
City
Sapporo-shi
State/Province
Hokkaido
ZIP/Postal Code
060-0031
Country
Japan
Facility Name
Research Site
City
Himeji-shi
State/Province
Hyogo
ZIP/Postal Code
672-8043
Country
Japan
Facility Name
Research Site
City
Toride-shi
State/Province
Ibaraki
ZIP/Postal Code
302-0022
Country
Japan
Facility Name
Research Site
City
Tsukuba-city
State/Province
Ibaraki
ZIP/Postal Code
305-8558
Country
Japan
Facility Name
Research Site
City
Kyoto-shi
State/Province
Kyoto
ZIP/Postal Code
615-0035
Country
Japan
Facility Name
Research Site
City
Okinawa-shi
State/Province
Okinawa
ZIP/Postal Code
904-8585
Country
Japan
Facility Name
Research Site
City
Shimajiri-gun
State/Province
Okinawa
ZIP/Postal Code
901-0493
Country
Japan
Facility Name
Research Site
City
Urasoe-shi
State/Province
Okinawa
ZIP/Postal Code
901-2132
Country
Japan
Facility Name
Research Site
City
Osaka-shi
State/Province
Osaka
ZIP/Postal Code
530-0001
Country
Japan
Facility Name
Research Site
City
Osaka-shi
State/Province
Osaka
ZIP/Postal Code
543-0035
Country
Japan
Facility Name
Research Site
City
Saga-shi
State/Province
Saga
ZIP/Postal Code
840-8571
Country
Japan
Facility Name
Research Site
City
Saga-shi
State/Province
Saga
ZIP/Postal Code
849-0917
Country
Japan
Facility Name
Research Site
City
Kawaguchi-shi
State/Province
Saitama
ZIP/Postal Code
332-8558
Country
Japan
Facility Name
Research Site
City
Komatsushima-shi
State/Province
Tokushima
ZIP/Postal Code
773-8502
Country
Japan
Facility Name
Research Site
City
Chuo-ku
State/Province
Tokyo
ZIP/Postal Code
103-0027
Country
Japan
Facility Name
Research Site
City
Daugavpils
ZIP/Postal Code
5417
Country
Latvia
Facility Name
Research Site
City
Kuldiga
ZIP/Postal Code
LV-3301
Country
Latvia
Facility Name
Research Site
City
Liepaja
ZIP/Postal Code
3402
Country
Latvia
Facility Name
Research Site
City
Ogre
ZIP/Postal Code
5001
Country
Latvia
Facility Name
Research Site
City
Ogre
ZIP/Postal Code
LV-5003
Country
Latvia
Facility Name
Research Site
City
Riga
ZIP/Postal Code
1012
Country
Latvia
Facility Name
Research Site
City
Riga
ZIP/Postal Code
LV-1001
Country
Latvia
Facility Name
Research Site
City
Vilnius
ZIP/Postal Code
10323
Country
Lithuania
Facility Name
Research Site
City
Kuala Lumpur
State/Province
Wilayah Persekutuan
ZIP/Postal Code
56000
Country
Malaysia
Facility Name
Research Site
City
Kuala Lumpur
ZIP/Postal Code
59100
Country
Malaysia
Facility Name
Research Site
City
Arnhem
ZIP/Postal Code
6815 AD
Country
Netherlands
Facility Name
Research Site
City
Ede
ZIP/Postal Code
6716 RP
Country
Netherlands
Facility Name
Research Site
City
Eindhoven
ZIP/Postal Code
5623 EJ
Country
Netherlands
Facility Name
Research Site
City
Hoorn
ZIP/Postal Code
1625 HV
Country
Netherlands
Facility Name
Research Site
City
Uden
ZIP/Postal Code
5406 PT
Country
Netherlands
Facility Name
Research Site
City
Christchurch
ZIP/Postal Code
8011
Country
New Zealand
Facility Name
Research Site
City
Tauranga
ZIP/Postal Code
3143
Country
New Zealand
Facility Name
Research Site
City
Hamar
ZIP/Postal Code
2317
Country
Norway
Facility Name
Research Site
City
Lierskogen
ZIP/Postal Code
3420
Country
Norway
Facility Name
Research Site
City
Oslo
ZIP/Postal Code
0450
Country
Norway
Facility Name
Research Site
City
Skedsmokorset
ZIP/Postal Code
2020
Country
Norway
Facility Name
Research Site
City
Skien
ZIP/Postal Code
3710
Country
Norway
Facility Name
Research Site
City
Stavanger
ZIP/Postal Code
4005
Country
Norway
Facility Name
Research Site
City
Ålesund
ZIP/Postal Code
6003
Country
Norway
Facility Name
Research Site
City
Gdansk
ZIP/Postal Code
80-952
Country
Poland
Facility Name
Research Site
City
Gdynia
ZIP/Postal Code
81-384
Country
Poland
Facility Name
Research Site
City
Gdynia
ZIP/Postal Code
81-402
Country
Poland
Facility Name
Research Site
City
Katowice
ZIP/Postal Code
40-018
Country
Poland
Facility Name
Research Site
City
Katowice
ZIP/Postal Code
40-040
Country
Poland
Facility Name
Research Site
City
Katowice
ZIP/Postal Code
40-084
Country
Poland
Facility Name
Research Site
City
Kielce
ZIP/Postal Code
25-020
Country
Poland
Facility Name
Research Site
City
Krakow
ZIP/Postal Code
31-216
Country
Poland
Facility Name
Research Site
City
Krakow
ZIP/Postal Code
32-082
Country
Poland
Facility Name
Research Site
City
Lodz
ZIP/Postal Code
90-368
Country
Poland
Facility Name
Research Site
City
Lodz
ZIP/Postal Code
91-347
Country
Poland
Facility Name
Research Site
City
Lublin
ZIP/Postal Code
20-857
Country
Poland
Facility Name
Research Site
City
Olsztyn
ZIP/Postal Code
10-010
Country
Poland
Facility Name
Research Site
City
Poznan
ZIP/Postal Code
60-702
Country
Poland
Facility Name
Research Site
City
Pulawy
ZIP/Postal Code
24-100
Country
Poland
Facility Name
Research Site
City
Ruda Slaska
ZIP/Postal Code
41-709
Country
Poland
Facility Name
Research Site
City
Staszow
ZIP/Postal Code
28-200
Country
Poland
Facility Name
Research Site
City
Swidnik
ZIP/Postal Code
21-040
Country
Poland
Facility Name
Research Site
City
Tarnow
ZIP/Postal Code
33-100
Country
Poland
Facility Name
Research Site
City
Torun
ZIP/Postal Code
87-100
Country
Poland
Facility Name
Research Site
City
Warszawa
ZIP/Postal Code
01-192
Country
Poland
Facility Name
Research Site
City
Warszawa
ZIP/Postal Code
02-507
Country
Poland
Facility Name
Research Site
City
Warszawa
ZIP/Postal Code
04-730
Country
Poland
Facility Name
Research Site
City
Wloclawek
ZIP/Postal Code
87-800
Country
Poland
Facility Name
Research Site
City
Wroclaw
ZIP/Postal Code
50-088
Country
Poland
Facility Name
Research Site
City
Wroclaw
ZIP/Postal Code
50-349
Country
Poland
Facility Name
Research Site
City
Wroclaw
ZIP/Postal Code
51-685
Country
Poland
Facility Name
Research Site
City
Zamosc
ZIP/Postal Code
22-400
Country
Poland
Facility Name
Research Site
City
Almada
ZIP/Postal Code
2801-951
Country
Portugal
Facility Name
Research Site
City
Carnaxide
ZIP/Postal Code
2790-134
Country
Portugal
Facility Name
Research Site
City
Coimbra
ZIP/Postal Code
3000-075
Country
Portugal
Facility Name
Research Site
City
Covilha
ZIP/Postal Code
6200-251
Country
Portugal
Facility Name
Research Site
City
Ekaterinburg
ZIP/Postal Code
620144
Country
Russian Federation
Facility Name
Research Site
City
Ivanovo
ZIP/Postal Code
153012
Country
Russian Federation
Facility Name
Research Site
City
Izhevsk
ZIP/Postal Code
426063
Country
Russian Federation
Facility Name
Research Site
City
Kemerovo
ZIP/Postal Code
650002
Country
Russian Federation
Facility Name
Research Site
City
Kemerovo
ZIP/Postal Code
650099
Country
Russian Federation
Facility Name
Research Site
City
Kirov
ZIP/Postal Code
610014
Country
Russian Federation
Facility Name
Research Site
City
Moscow
ZIP/Postal Code
117292
Country
Russian Federation
Facility Name
Research Site
City
Moscow
ZIP/Postal Code
121552
Country
Russian Federation
Facility Name
Research Site
City
Nizhniy Novgorod
ZIP/Postal Code
603076
Country
Russian Federation
Facility Name
Research Site
City
Novosibirsk
ZIP/Postal Code
630089
Country
Russian Federation
Facility Name
Research Site
City
Omsk
ZIP/Postal Code
644018
Country
Russian Federation
Facility Name
Research Site
City
Pushkin
ZIP/Postal Code
196601
Country
Russian Federation
Facility Name
Research Site
City
Saint Petersburg
ZIP/Postal Code
192242
Country
Russian Federation
Facility Name
Research Site
City
Saint Petersburg
ZIP/Postal Code
197022
Country
Russian Federation
Facility Name
Research Site
City
Saint-Petersburg
ZIP/Postal Code
199106
Country
Russian Federation
Facility Name
Research Site
City
Saratov
ZIP/Postal Code
410054
Country
Russian Federation
Facility Name
Research Site
City
St. Petersburg
ZIP/Postal Code
191015
Country
Russian Federation
Facility Name
Research Site
City
Tomsk
ZIP/Postal Code
634012
Country
Russian Federation
Facility Name
Research Site
City
Bardejov
ZIP/Postal Code
085 01
Country
Slovakia
Facility Name
Research Site
City
Brezno
ZIP/Postal Code
977 42
Country
Slovakia
Facility Name
Research Site
City
Kosice
ZIP/Postal Code
040 22
Country
Slovakia
Facility Name
Research Site
City
Lucenec
ZIP/Postal Code
984 01
Country
Slovakia
Facility Name
Research Site
City
Moldava nad Bodvou
ZIP/Postal Code
045 01
Country
Slovakia
Facility Name
Research Site
City
Nove Zamky
ZIP/Postal Code
940 01
Country
Slovakia
Facility Name
Research Site
City
Rimavska Sobota
ZIP/Postal Code
979 01
Country
Slovakia
Facility Name
Research Site
City
Roznava
ZIP/Postal Code
048 01
Country
Slovakia
Facility Name
Research Site
City
Snina
ZIP/Postal Code
069 01
Country
Slovakia
Facility Name
Research Site
City
Svidnik
ZIP/Postal Code
08901
Country
Slovakia
Facility Name
Research Site
City
Trencin
ZIP/Postal Code
911 01
Country
Slovakia
Facility Name
Research Site
City
Trnava
ZIP/Postal Code
917 01
Country
Slovakia
Facility Name
Research Site
City
Centurion
State/Province
Gauteng
ZIP/Postal Code
0158
Country
South Africa
Facility Name
Research Site
City
Johannesburg
State/Province
Gauteng
ZIP/Postal Code
1724
Country
South Africa
Facility Name
Research Site
City
Johannesburg
State/Province
Gauteng
ZIP/Postal Code
2196
Country
South Africa
Facility Name
Research Site
City
Pretoria west
State/Province
Gauteng
ZIP/Postal Code
0183
Country
South Africa
Facility Name
Research Site
City
Pretoria
State/Province
Gauteng
ZIP/Postal Code
0184
Country
South Africa
Facility Name
Research Site
City
Paarl
State/Province
Western Cape
ZIP/Postal Code
7646
Country
South Africa
Facility Name
Research Site
City
Parow
State/Province
Western Cape
ZIP/Postal Code
7505
Country
South Africa
Facility Name
Research Site
City
Somerset West
State/Province
Western Cape
ZIP/Postal Code
7130
Country
South Africa
Facility Name
Research Site
City
Worcester
State/Province
Western Cape
ZIP/Postal Code
6850
Country
South Africa
Facility Name
Research Site
City
Cape Town
ZIP/Postal Code
7530
Country
South Africa
Facility Name
Research Site
City
Kempton Park
ZIP/Postal Code
1619
Country
South Africa
Facility Name
Research Site
City
Zaragoza
State/Province
Aragón
ZIP/Postal Code
50009
Country
Spain
Facility Name
Research Site
City
L'Hospitalet de Llobregat
State/Province
Cataluña
ZIP/Postal Code
08907
Country
Spain
Facility Name
Research Site
City
Valencia
State/Province
Comunidad Valenciana
ZIP/Postal Code
46010
Country
Spain
Facility Name
Research Site
City
Santiago de Compostela
State/Province
Galicia
ZIP/Postal Code
15706
Country
Spain
Facility Name
Research Site
City
Vigo
State/Province
Galicia
ZIP/Postal Code
36200
Country
Spain
Facility Name
Research Site
City
Galdakao
State/Province
País Vasco
ZIP/Postal Code
48960
Country
Spain
Facility Name
Research Site
City
Madrid
ZIP/Postal Code
28034
Country
Spain
Facility Name
Research Site
City
Helsingborg
ZIP/Postal Code
251 87
Country
Sweden
Facility Name
Research Site
City
Linköping
ZIP/Postal Code
581 85
Country
Sweden
Facility Name
Research Site
City
Lund
ZIP/Postal Code
222 21
Country
Sweden
Facility Name
Research Site
City
Stockholm
ZIP/Postal Code
111 35
Country
Sweden
Facility Name
Research Site
City
Stockholm
ZIP/Postal Code
171 76
Country
Sweden
Facility Name
Research Site
City
Uddevalla
ZIP/Postal Code
451 50
Country
Sweden
Facility Name
Research Site
City
Västerås
ZIP/Postal Code
721 89
Country
Sweden
Facility Name
Research Site
City
Adana
ZIP/Postal Code
01330
Country
Turkey
Facility Name
Research Site
City
Ankara
ZIP/Postal Code
06100
Country
Turkey
Facility Name
Research Site
City
Gaziantep
ZIP/Postal Code
27310
Country
Turkey
Facility Name
Research Site
City
Istanbul
ZIP/Postal Code
34096
Country
Turkey
Facility Name
Research Site
City
Istanbul
ZIP/Postal Code
34865
Country
Turkey
Facility Name
Research Site
City
Izmir
ZIP/Postal Code
35100
Country
Turkey
Facility Name
Research Site
City
Kocaeli
ZIP/Postal Code
41380
Country
Turkey
Facility Name
Research Site
City
Belfast
ZIP/Postal Code
BT7 2EB
Country
United Kingdom
Facility Name
Research Site
City
Birmingham
ZIP/Postal Code
B15 2SQ
Country
United Kingdom
Facility Name
Research Site
City
Birmingham
ZIP/Postal Code
B18 7QH
Country
United Kingdom
Facility Name
Research Site
City
Bournemouth
ZIP/Postal Code
BH7 7DW
Country
United Kingdom
Facility Name
Research Site
City
Cardiff
ZIP/Postal Code
CF14 5GJ
Country
United Kingdom
Facility Name
Research Site
City
Chesterfield
ZIP/Postal Code
S40 4AA
Country
United Kingdom
Facility Name
Research Site
City
Chippenham
ZIP/Postal Code
SN15 2SB
Country
United Kingdom
Facility Name
Research Site
City
Chorley
ZIP/Postal Code
PR7 7NA
Country
United Kingdom
Facility Name
Research Site
City
Doncaster
ZIP/Postal Code
DN9 1EP
Country
United Kingdom
Facility Name
Research Site
City
Glasgow
ZIP/Postal Code
G20 0SP
Country
United Kingdom
Facility Name
Research Site
City
Glasgow
ZIP/Postal Code
G45 9AW
Country
United Kingdom
Facility Name
Research Site
City
Hexham
ZIP/Postal Code
NE46 1QJ
Country
United Kingdom
Facility Name
Research Site
City
Leicester
ZIP/Postal Code
LE3 9QP
Country
United Kingdom
Facility Name
Research Site
City
Liverpool
ZIP/Postal Code
L22 0LG
Country
United Kingdom
Facility Name
Research Site
City
Liverpool
ZIP/Postal Code
L9 7AL
Country
United Kingdom
Facility Name
Research Site
City
London
ZIP/Postal Code
EC1M 6BQ
Country
United Kingdom
Facility Name
Research Site
City
London
ZIP/Postal Code
W2 1LA
Country
United Kingdom
Facility Name
Research Site
City
Manchester
ZIP/Postal Code
M15 6SX
Country
United Kingdom
Facility Name
Research Site
City
Manchester
ZIP/Postal Code
M23 9LT
Country
United Kingdom
Facility Name
Research Site
City
Newport
ZIP/Postal Code
PO30 5TG
Country
United Kingdom
Facility Name
Research Site
City
Nuneaton
ZIP/Postal Code
CV10 7DJ
Country
United Kingdom
Facility Name
Research Site
City
Reading
ZIP/Postal Code
RG2 0TG
Country
United Kingdom
Facility Name
Research Site
City
Sandbach
ZIP/Postal Code
CW11 1EQ
Country
United Kingdom
Facility Name
Research Site
City
Sheffield
ZIP/Postal Code
S5 7AU
Country
United Kingdom
Facility Name
Research Site
City
West Bromwich
ZIP/Postal Code
B71 4HJ
Country
United Kingdom
Facility Name
Research Site
City
Whitby
ZIP/Postal Code
YO21 1SD
Country
United Kingdom
Facility Name
Research Site
City
Worcester
ZIP/Postal Code
WR5 1DD
Country
United Kingdom

12. IPD Sharing Statement

Citations:
PubMed Identifier
28207168
Citation
Giugliano RP, Mach F, Zavitz K, Kurtz C, Schneider J, Wang H, Keech A, Pedersen TR, Sabatine MS, Sever PS, Honarpour N, Wasserman SM, Ott BR; EBBINGHAUS Investigators. Design and rationale of the EBBINGHAUS trial: A phase 3, double-blind, placebo-controlled, multicenter study to assess the effect of evolocumab on cognitive function in patients with clinically evident cardiovascular disease and receiving statin background lipid-lowering therapy-A cognitive study of patients enrolled in the FOURIER trial. Clin Cardiol. 2017 Feb;40(2):59-65. doi: 10.1002/clc.22678. Epub 2017 Feb 16.
Results Reference
background
PubMed Identifier
28813214
Citation
Giugliano RP, Mach F, Zavitz K, Kurtz C, Im K, Kanevsky E, Schneider J, Wang H, Keech A, Pedersen TR, Sabatine MS, Sever PS, Robinson JG, Honarpour N, Wasserman SM, Ott BR; EBBINGHAUS Investigators. Cognitive Function in a Randomized Trial of Evolocumab. N Engl J Med. 2017 Aug 17;377(7):633-643. doi: 10.1056/NEJMoa1701131.
Results Reference
background
PubMed Identifier
33078867
Citation
Schmidt AF, Carter JL, Pearce LS, Wilkins JT, Overington JP, Hingorani AD, Casas JP. PCSK9 monoclonal antibodies for the primary and secondary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2020 Oct 20;10(10):CD011748. doi: 10.1002/14651858.CD011748.pub3.
Results Reference
derived
Links:
URL
http://www.amgentrials.com
Description
AmgenTrials clinical trials website

Learn more about this trial

Evaluating PCSK9 Binding antiBody Influence oN coGnitive HeAlth in High cardiovascUlar Risk Subjects

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