Value of Patch Testing in Direct Diet Therapy for Eosinophilic Esophagitis (EoE)
Eosinophilic Esophagitis
About this trial
This is an interventional diagnostic trial for Eosinophilic Esophagitis focused on measuring Allergy Patch testing, Eosinophilic Esophagitis, EoE
Eligibility Criteria
Inclusion criteria:
- Adults ages 18-90
- Patients with EoE, defined as dysphagia with histologic finding of greater than or equal to 15 eosinophils per high powered field (eos per HPF) on index esophageal biopsy
- Persistent symptoms and/or greater than or equal to 10 eos per HPF on esophageal biopsy after at least 8 weeks of twice daily PPI therapy
Exclusion criteria:
- Patients with conditions known to be associated with esophageal eosinophilia, including Crohn's disease, Churg-Strauss, achalasia, and hypereosinophilic syndrome
- Topical swallowed steroids within 8 weeks of study enrollment
- Dermatologic conditions precluding application of Finn chambers to the skin for APT
- Inability to read due to: Blindness, cognitive dysfunction, or English language illiteracy
Sites / Locations
- Mayo Clinic
Arms of the Study
Arm 1
Experimental
Allergy Patch Testing APT
Patient will undergo APT testing per the following protocol: 2g of dry foods will be placed in 2ml of isotonic saline solution. The mixtures will then be placed in aluminum cups (ie Finn chambers) measuring 6 or 12 mm in diameter and adhered to the patient's back. Foods to be included will be milk, wheat, egg, soy, peanut, tree nut, fish, shellfish, beef, corn, chicken, potato, pork, legumes, barley, rye, tomato, rice, fruits The patches will be removed at 48 hours, and results read at 72 and 120 hours after application Reactions will be classified as negative, + (erythema and scattered papules), ++ (erythema and papules), and +++ (erythema and vesicles).