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Efficacy and Safety of Abelmoschus Manihot for IgA Nephropathy

Primary Purpose

IgA Nephropathy

Status
Unknown status
Phase
Phase 4
Locations
China
Study Type
Interventional
Intervention
Losartan
Abelmoschus manihot
Sponsored by
Chen Xiangmei
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for IgA Nephropathy focused on measuring Abelmoschus manihot, IgA Nephropathy, proteinuria, efficacy, safety

Eligibility Criteria

18 Years - 65 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Clinical diagnosed as chronic nephritic syndrome
  • IgA nephropathy diagnosed by kidney biopsy
  • Aged from 18 to 65 years，male or female
  • Blood pressure of ≤140/90mmHg
  • Estimated Glomerular Filtration Rate (eGFR)≥45ml/min/1.73 m2
  • 24-hour proteinuria ranged between 0.5g-3.0g
  • Obtaining the signed informed consent from patients

Exclusion Criteria:

  • Secondary IgA nephropathy
  • Be allergic to Huangkui Capsule or Losartan potassium tablet
  • Taken Huangkui Capsule or ACEI or ARB in last 6 weeks
  • Taken the glucocorticoids, immunosuppressants or common threewingnut root and such as drugs with immunosuppressive actions in the last 12 months
  • Blood pressure <90/60mmHg
  • Serum potassium level > 5.5mmol / L
  • Serum albumin level <30g / L
  • Lactation, pregnancy or plans pregnancy during the study period
  • Unilateral or bilateral renal artery stenosis
  • Combined with severe primary diseases of heart, brain, liver and hematopoietic system and so on, or other serious diseases which can affect the patient's life
  • Participating in another clinical study in the same period

Sites / Locations

  • The First Hospital of Anhui Medical University
  • The Second Hospital of Anhui Medical University
  • Beijing Chao-yang Hospital
  • China-Japan Friendship HospitalRecruiting
  • Chinese PLA General Hospital
  • Dong Zhi Men Hospital of Beijing University of Chinese Medicine
  • Guang An Men Hospital China Academy of Chinese Medical Sciences
  • PLA Navy General Hospital
  • The Second Artillery General Hospital Of Chinese People's Liberation ArmyRecruiting
  • Da Ping Hospital Of Third Military Medical University
  • Yongchuan Hospital Of Chongqing Medical University
  • Chinese People's Liberation Army No.180 HospitalRecruiting
  • Chinese People's Liberation Army No.174 Hospital
  • The First Hospital of Lanzhou UniversityRecruiting
  • The Second Hospital of Lanzhou UniversityRecruiting
  • 421 Hospital of PLARecruiting
  • Guangdong Province Hospital of Traditional Chinese Medicine(TCM)Recruiting
  • Affiliated Hospital of Guilin Medical University
  • The First Affiliated Hospital of Guangxi Medical University
  • The First Affiliated Hospital of Guangxi University of Chinese Medicine
  • Affiliated Hospital of Guiyang Medical College
  • The Affiliated Baiyun Hospital of Guizhou Medical University
  • Affiliated Hospital Of Zun Yi Medical CollegeRecruiting
  • Hainan Medical College Affiliated Hospital
  • Hainan Provincial Nong Ken Hospital
  • Affiliated Hospital of Cheng De Medical College
  • First Hospital of Qinhuangdao
  • Hebei Province Hospital of Traditional Chinese Medicine
  • TCM Hospital of Shi Jia Zhuang City
  • The Second Hospital of Hebei Medical UniversityRecruiting
  • Heilongjiang Provincial Academy of Traditional Chinese Medicine
  • The Second Affiliated Hospital of Harbin Medical University
  • The First Affiliated Hospital of Henan University of Science And Technology
  • The First Affiliated Hospital of Xinxiang Medical UniversityRecruiting
  • Henan Provincial People's HospitalRecruiting
  • The First Affiliated Hospital of Zhengzhou University
  • Huang Gang Central Hospital
  • Hubei Provincial Hospital Of TCM
  • Wuhan Integrated TCM & Western Medicine Hospital
  • Zhong Nan Hospital of Wuhan University
  • The Second Xiang Ya Hospital of Central South University
  • The Third Xiang Ya Hospital of Central South University
  • Xiangya Hospital Central South University
  • Jiangsu Province Hospital of Traditional Chinese MedicineRecruiting
  • Jiangsu Provincial People's Hospital
  • Affiliated Hospital of Nantong UniversityRecruiting
  • Jiangsu Taizhou People's Hospital
  • Taizhou Traditional Chinese Medicine Hospital
  • Xuzhou Central Hospital
  • Chinese People's Liberation Army No.94 Hospital
  • Jiangxi Provincial People's Hospital
  • The First Affiliated Hospital Of Nanchang University
  • The Second Affiliated Hospital Of Nanchang University
  • Jiangxi Pingxiang People's Hospital
  • Jilin Province People's Hospital
  • The First Hospital of Jilin University
  • The Second Hospital Of Jilin University
  • Dalian Municipal Central Hospital Affiliated Of Dalian Medical University
  • The First Affiliated Hospital Of Dalian Medical University
  • First Affiliated Hospital of Liaoning Medical University
  • People's Liberation Army No.202 Hospital
  • Shengjing Hospital of China Medical University
  • The First Hospital Of China Medical University
  • The General Hospital Of Shenyang Military Region
  • Ningxia Hui Autonomous Region's HospitalRecruiting
  • The General Hospital of Ningxia Medical University
  • Jinan General Hospital of PLA
  • Qi Lu Hospital of Shandong University
  • Affiliated Hospital of Jining Medical University
  • Jining No.1 People's Hospital
  • Chinese People's Liberation Army No.88 Hospital
  • Yantai Yu Huang Ding Hospital
  • Zaozhuang Municipal Hospital
  • Chang Hai Hospital of the Second Military Medical University
  • Ren Ji Hospital of Shanghai Jiao Tong University School of Medicine
  • Shanghai Sixth People's Hospital Affiliated Shanghai Jiao Tong University School of Medicine
  • The First Hospital of Shanxi Medical University
  • The Second Hospital of Shanxi Medical University
  • Shanxi Provincial People's Hospital
  • The First Affiliated Hospital of Xi'an Jiao Tong University
  • Hua Xi Hospital of Sichuan University
  • First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
  • The Second Hospital of Tianjin Medical University
  • Tianjin Hospital of ITCWM, Nankai Hospital
  • The First Hospital of Shi He Zi Medical UniversityRecruiting
  • The Second Affiliated Hospital of Kunming Medical University
  • Yan'an Hospital of Kunming CityRecruiting
  • Zhejiang Provincial People's Hospital

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Experimental

Arm Label

Abelmoschus manihot (AM)

Losartan

Arm Description

Abelmoschus manihot (AM): Huangkui capsule (Jiangsu Suzhong Pharmaceutical Group Co., Ltd.), 0.5 g × 30 capsules/box. A huangkui capsule is a single plant drug extract of Flos Abelmoschus manihot.

Losartan potassium (Hangzhou MSD Pharmaceutical Co., Ltd.), 100 mg × 7 capsules/box.

Outcomes

Primary Outcome Measures

Change in 24-h proteinuria from baseline after treatment

Secondary Outcome Measures

Change in serum creatinine from baseline after treatment
Change in estimated glomerular filtration rate (eGFR) from baseline after treatment

Full Information

First Posted
August 30, 2014
Last Updated
July 4, 2016
Sponsor
Chen Xiangmei
Collaborators
Jiangsu Suzhong Pharmaceutical Group Co., Ltd.
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1. Study Identification

Unique Protocol Identification Number
NCT02231125
Brief Title
Efficacy and Safety of Abelmoschus Manihot for IgA Nephropathy
Official Title
Efficacy and Safety of Abelmoschus Manihot for IgA Nephropathy: a Multicentre, Double-blind, Double-dummy, Randomized Controlled Trial
Study Type
Interventional

2. Study Status

Record Verification Date
July 2016
Overall Recruitment Status
Unknown status
Study Start Date
September 2014 (undefined)
Primary Completion Date
July 2016 (Anticipated)
Study Completion Date
December 2017 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor-Investigator
Name of the Sponsor
Chen Xiangmei
Collaborators
Jiangsu Suzhong Pharmaceutical Group Co., Ltd.

4. Oversight

Data Monitoring Committee
Yes

5. Study Description

Brief Summary
-IgA nephropathy is the most common primary glomerular disease in China, Huangkui Capsule is a single medicament of traditional Chinese medicine consists of Abelmoschus manihot and has been widely used to treat kidney disease. The purpose of this study is to evaluate the safety and efficacy of Abelmoschus manihot for treating IgA nephropathy in large scale samples with long time take.
Detailed Description
The test has not been completed .

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
IgA Nephropathy
Keywords
Abelmoschus manihot, IgA Nephropathy, proteinuria, efficacy, safety

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 4
Interventional Study Model
Parallel Assignment
Masking
ParticipantCare Provider
Allocation
Randomized
Enrollment
1600 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Abelmoschus manihot (AM)
Arm Type
Experimental
Arm Description
Abelmoschus manihot (AM): Huangkui capsule (Jiangsu Suzhong Pharmaceutical Group Co., Ltd.), 0.5 g × 30 capsules/box. A huangkui capsule is a single plant drug extract of Flos Abelmoschus manihot.
Arm Title
Losartan
Arm Type
Experimental
Arm Description
Losartan potassium (Hangzhou MSD Pharmaceutical Co., Ltd.), 100 mg × 7 capsules/box.
Intervention Type
Drug
Intervention Name(s)
Losartan
Other Intervention Name(s)
Cozaar
Intervention Description
Losartan potassium tablet 100mg/time, once /day plus Huangkui Capsule dummy 2.5g/time, thrice /day, all drug and dummy are taken orally every day for 48 weeks during the whole study process.
Intervention Type
Drug
Intervention Name(s)
Abelmoschus manihot
Other Intervention Name(s)
Huangkui Capsule
Intervention Description
Huangkui Capsule 2.5g/time, thrice /day plus Losartan potassium tablet dummy 100mg/time, once /day, all drug and dummy are taken orally every day for 48 weeks during the whole study process.
Primary Outcome Measure Information:
Title
Change in 24-h proteinuria from baseline after treatment
Time Frame
Baseline(week 0), week 4, week 12, week 24, week 36, week 48
Secondary Outcome Measure Information:
Title
Change in serum creatinine from baseline after treatment
Time Frame
Baseline(week 0), week 4, week 12, week 24, week 36, week 48
Title
Change in estimated glomerular filtration rate (eGFR) from baseline after treatment
Time Frame
Baseline(week 0), week 4, week 12, week 24, week 36, week 48

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
65 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Clinical diagnosed as chronic nephritic syndrome IgA nephropathy diagnosed by kidney biopsy Aged from 18 to 65 years，male or female Blood pressure of ≤140/90mmHg Estimated Glomerular Filtration Rate (eGFR)≥45ml/min/1.73 m2 24-hour proteinuria ranged between 0.5g-3.0g Obtaining the signed informed consent from patients Exclusion Criteria: Secondary IgA nephropathy Be allergic to Huangkui Capsule or Losartan potassium tablet Taken Huangkui Capsule or ACEI or ARB in last 6 weeks Taken the glucocorticoids, immunosuppressants or common threewingnut root and such as drugs with immunosuppressive actions in the last 12 months Blood pressure <90/60mmHg Serum potassium level > 5.5mmol / L Serum albumin level <30g / L Lactation, pregnancy or plans pregnancy during the study period Unilateral or bilateral renal artery stenosis Combined with severe primary diseases of heart, brain, liver and hematopoietic system and so on, or other serious diseases which can affect the patient's life Participating in another clinical study in the same period
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Xiangmei Chen, MD.&Ph.D
Phone
+86-10-66935462
Email
xmchen301@126.com
First Name & Middle Initial & Last Name or Official Title & Degree
Xuefeng Sun, MD.&Ph.D
Phone
+86-10-66937077
Email
xfssun@126.com
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Xiangmei Chen, MD.& Ph.D
Organizational Affiliation
Department of Nephrology,State Key Laboratory of Kidney Disease,National Clinical Research Center for Kidney Disease, Chinese PLA General Hospital
Official's Role
Principal Investigator
Facility Information:
Facility Name
The First Hospital of Anhui Medical University
City
Hefei
State/Province
Anhui
ZIP/Postal Code
230000
Country
China
Individual Site Status
Completed
Facility Name
The Second Hospital of Anhui Medical University
City
Hefei
State/Province
Anhui
ZIP/Postal Code
230000
Country
China
Individual Site Status
Completed
Facility Name
Beijing Chao-yang Hospital
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100000
Country
China
Individual Site Status
Completed
Facility Name
China-Japan Friendship Hospital
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Wenge Li
Phone
+86-13521961922
Email
wenge_lee2002@126.com
Facility Name
Chinese PLA General Hospital
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100000
Country
China
Individual Site Status
Completed
Facility Name
Dong Zhi Men Hospital of Beijing University of Chinese Medicine
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100000
Country
China
Individual Site Status
Completed
Facility Name
Guang An Men Hospital China Academy of Chinese Medical Sciences
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100000
Country
China
Individual Site Status
Completed
Facility Name
PLA Navy General Hospital
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100000
Country
China
Individual Site Status
Completed
Facility Name
The Second Artillery General Hospital Of Chinese People's Liberation Army
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xiaowen Tu
Phone
+86-18910883406
Email
xiaowentu@sohu.com
Facility Name
Da Ping Hospital Of Third Military Medical University
City
Chongqing
State/Province
Chongqing
ZIP/Postal Code
400000
Country
China
Individual Site Status
Completed
Facility Name
Yongchuan Hospital Of Chongqing Medical University
City
Chongqing
State/Province
Chongqing
ZIP/Postal Code
400000
Country
China
Individual Site Status
Completed
Facility Name
Chinese People's Liberation Army No.180 Hospital
City
Quanzhou
State/Province
Fujian
ZIP/Postal Code
362000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Li Cheng
Phone
+86-13313835596
Email
cl20060606@sina.com
Facility Name
Chinese People's Liberation Army No.174 Hospital
City
Xiamen
State/Province
Fujian
ZIP/Postal Code
361000
Country
China
Individual Site Status
Completed
Facility Name
The First Hospital of Lanzhou University
City
Lanzhou
State/Province
Gansu
ZIP/Postal Code
730000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Tianxi Liu
Phone
+86-13919060937
Email
liutianxi@medmail.com.cn
Facility Name
The Second Hospital of Lanzhou University
City
Lanzhou
State/Province
Gansu
ZIP/Postal Code
730000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jianqin Wang
Phone
+86-13919038189
Email
wangjianqin@medmail.com.cn
Facility Name
421 Hospital of PLA
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Chaoxin Xie
Phone
+86-13332889488
Email
xcx421@163.com
Facility Name
Guangdong Province Hospital of Traditional Chinese Medicine(TCM)
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xusheng Liu
Phone
+86-13503078703
Email
liuxu801@126.com
Facility Name
Affiliated Hospital of Guilin Medical University
City
Guilin
State/Province
Guangxi
ZIP/Postal Code
541000
Country
China
Individual Site Status
Completed
Facility Name
The First Affiliated Hospital of Guangxi Medical University
City
Nanning
State/Province
Guangxi
ZIP/Postal Code
530000
Country
China
Individual Site Status
Completed
Facility Name
The First Affiliated Hospital of Guangxi University of Chinese Medicine
City
Nanning
State/Province
Guangxi
ZIP/Postal Code
530000
Country
China
Individual Site Status
Completed
Facility Name
Affiliated Hospital of Guiyang Medical College
City
Guiyang
State/Province
Guizhou
ZIP/Postal Code
550000
Country
China
Individual Site Status
Completed
Facility Name
The Affiliated Baiyun Hospital of Guizhou Medical University
City
Guiyang
State/Province
Guizhou
ZIP/Postal Code
550000
Country
China
Individual Site Status
Completed
Facility Name
Affiliated Hospital Of Zun Yi Medical College
City
Zunyi
State/Province
Guizhou
ZIP/Postal Code
563000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yibin Yang
Phone
+86-13765930909
Email
yyb1011@sina.com
Facility Name
Hainan Medical College Affiliated Hospital
City
Haikou
State/Province
Hainan
ZIP/Postal Code
570100
Country
China
Individual Site Status
Completed
Facility Name
Hainan Provincial Nong Ken Hospital
City
Haikou
State/Province
Hainan
ZIP/Postal Code
570100
Country
China
Individual Site Status
Completed
Facility Name
Affiliated Hospital of Cheng De Medical College
City
Chengde
State/Province
Hebei
ZIP/Postal Code
067000
Country
China
Individual Site Status
Completed
Facility Name
First Hospital of Qinhuangdao
City
Qinhuangdao
State/Province
Hebei
ZIP/Postal Code
066000
Country
China
Individual Site Status
Completed
Facility Name
Hebei Province Hospital of Traditional Chinese Medicine
City
Shijiazhuang
State/Province
Hebei
ZIP/Postal Code
050000
Country
China
Individual Site Status
Completed
Facility Name
TCM Hospital of Shi Jia Zhuang City
City
Shijiazhuang
State/Province
Hebei
ZIP/Postal Code
050000
Country
China
Individual Site Status
Completed
Facility Name
The Second Hospital of Hebei Medical University
City
Shijiazhuang
State/Province
Hebei
ZIP/Postal Code
050000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Shuxia Fu
Phone
+86-15803210953
Email
fushuxia99@163.com
Facility Name
Heilongjiang Provincial Academy of Traditional Chinese Medicine
City
Haerbin
State/Province
Heilongjiang
ZIP/Postal Code
150000
Country
China
Individual Site Status
Completed
Facility Name
The Second Affiliated Hospital of Harbin Medical University
City
Haerbin
State/Province
Heilongjiang
ZIP/Postal Code
150000
Country
China
Individual Site Status
Completed
Facility Name
The First Affiliated Hospital of Henan University of Science And Technology
City
Luoyang
State/Province
Henan
ZIP/Postal Code
471000
Country
China
Individual Site Status
Completed
Facility Name
The First Affiliated Hospital of Xinxiang Medical University
City
Xinxiang
State/Province
Henan
ZIP/Postal Code
453000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Minghao Guo
Phone
+86-13937315636
Email
guomh@163.com
Facility Name
Henan Provincial People's Hospital
City
Zhengzhou
State/Province
Henan
ZIP/Postal Code
450000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Fengmin Shao
Phone
+86-13607655698
Email
fengminshao@medmail.com.cn
Facility Name
The First Affiliated Hospital of Zhengzhou University
City
Zhengzhou
State/Province
Henan
ZIP/Postal Code
450000
Country
China
Individual Site Status
Completed
Facility Name
Huang Gang Central Hospital
City
Huanggang
State/Province
Hubei
ZIP/Postal Code
438000
Country
China
Individual Site Status
Completed
Facility Name
Hubei Provincial Hospital Of TCM
City
Wuhan
State/Province
Hubei
ZIP/Postal Code
430000
Country
China
Individual Site Status
Completed
Facility Name
Wuhan Integrated TCM & Western Medicine Hospital
City
Wuhan
State/Province
Hubei
ZIP/Postal Code
430000
Country
China
Individual Site Status
Completed
Facility Name
Zhong Nan Hospital of Wuhan University
City
Wuhan
State/Province
Hubei
ZIP/Postal Code
430000
Country
China
Individual Site Status
Completed
Facility Name
The Second Xiang Ya Hospital of Central South University
City
Changsha
State/Province
Hunan
ZIP/Postal Code
410000
Country
China
Individual Site Status
Completed
Facility Name
The Third Xiang Ya Hospital of Central South University
City
Changsha
State/Province
Hunan
ZIP/Postal Code
410000
Country
China
Individual Site Status
Completed
Facility Name
Xiangya Hospital Central South University
City
Changsha
State/Province
Hunan
ZIP/Postal Code
410000
Country
China
Individual Site Status
Completed
Facility Name
Jiangsu Province Hospital of Traditional Chinese Medicine
City
Nanjing
State/Province
Jiangsu
ZIP/Postal Code
210000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Wei Sun
Phone
+86-13505199810
Email
jssunwei@163.com
Facility Name
Jiangsu Provincial People's Hospital
City
Nanjing
State/Province
Jiangsu
ZIP/Postal Code
210000
Country
China
Individual Site Status
Completed
Facility Name
Affiliated Hospital of Nantong University
City
Nantong
State/Province
Jiangsu
ZIP/Postal Code
226000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yaping Fan
Phone
+86-15962998446
Email
fanyp19107@medmail.com.cn
Facility Name
Jiangsu Taizhou People's Hospital
City
Taizhou
State/Province
Jiangsu
ZIP/Postal Code
225300
Country
China
Individual Site Status
Completed
Facility Name
Taizhou Traditional Chinese Medicine Hospital
City
Taizhou
State/Province
Jiangsu
ZIP/Postal Code
225300
Country
China
Individual Site Status
Completed
Facility Name
Xuzhou Central Hospital
City
Xuzhou
State/Province
Jiangsu
ZIP/Postal Code
221000
Country
China
Individual Site Status
Completed
Facility Name
Chinese People's Liberation Army No.94 Hospital
City
Nanchang
State/Province
Jiangxi
ZIP/Postal Code
330000
Country
China
Individual Site Status
Completed
Facility Name
Jiangxi Provincial People's Hospital
City
Nanchang
State/Province
Jiangxi
ZIP/Postal Code
330000
Country
China
Individual Site Status
Completed
Facility Name
The First Affiliated Hospital Of Nanchang University
City
Nanchang
State/Province
Jiangxi
ZIP/Postal Code
330000
Country
China
Individual Site Status
Completed
Facility Name
The Second Affiliated Hospital Of Nanchang University
City
Nanchang
State/Province
Jiangxi
ZIP/Postal Code
330000
Country
China
Individual Site Status
Completed
Facility Name
Jiangxi Pingxiang People's Hospital
City
Pingxiang
State/Province
Jiangxi
ZIP/Postal Code
337000
Country
China
Individual Site Status
Completed
Facility Name
Jilin Province People's Hospital
City
Changchun
State/Province
Jilin
ZIP/Postal Code
130000
Country
China
Individual Site Status
Completed
Facility Name
The First Hospital of Jilin University
City
Changchun
State/Province
Jilin
ZIP/Postal Code
130000
Country
China
Individual Site Status
Completed
Facility Name
The Second Hospital Of Jilin University
City
Changchun
State/Province
Jilin
ZIP/Postal Code
130000
Country
China
Individual Site Status
Completed
Facility Name
Dalian Municipal Central Hospital Affiliated Of Dalian Medical University
City
Dalian
State/Province
Liaoning
ZIP/Postal Code
116000
Country
China
Individual Site Status
Completed
Facility Name
The First Affiliated Hospital Of Dalian Medical University
City
Dalian
State/Province
Liaoning
ZIP/Postal Code
116000
Country
China
Individual Site Status
Completed
Facility Name
First Affiliated Hospital of Liaoning Medical University
City
Jinzhou
State/Province
Liaoning
ZIP/Postal Code
121000
Country
China
Individual Site Status
Completed
Facility Name
People's Liberation Army No.202 Hospital
City
Shenyang
State/Province
Liaoning
ZIP/Postal Code
110000
Country
China
Individual Site Status
Completed
Facility Name
Shengjing Hospital of China Medical University
City
Shenyang
State/Province
Liaoning
ZIP/Postal Code
110000
Country
China
Individual Site Status
Completed
Facility Name
The First Hospital Of China Medical University
City
Shenyang
State/Province
Liaoning
ZIP/Postal Code
110000
Country
China
Individual Site Status
Completed
Facility Name
The General Hospital Of Shenyang Military Region
City
Shenyang
State/Province
Liaoning
ZIP/Postal Code
110000
Country
China
Individual Site Status
Completed
Facility Name
Ningxia Hui Autonomous Region's Hospital
City
Yinchuan
State/Province
Ningxia
ZIP/Postal Code
750000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yali Zheng
Phone
+86-13639505291
Email
424570556@qq.com
Facility Name
The General Hospital of Ningxia Medical University
City
Yinchuan
State/Province
Ningxia
ZIP/Postal Code
750000
Country
China
Individual Site Status
Completed
Facility Name
Jinan General Hospital of PLA
City
Jinan
State/Province
Shandong
ZIP/Postal Code
250000
Country
China
Individual Site Status
Completed
Facility Name
Qi Lu Hospital of Shandong University
City
Jinan
State/Province
Shandong
ZIP/Postal Code
250000
Country
China
Individual Site Status
Withdrawn
Facility Name
Affiliated Hospital of Jining Medical University
City
Jining
State/Province
Shandong
ZIP/Postal Code
272000
Country
China
Individual Site Status
Completed
Facility Name
Jining No.1 People's Hospital
City
Jining
State/Province
Shandong
ZIP/Postal Code
272000
Country
China
Individual Site Status
Completed
Facility Name
Chinese People's Liberation Army No.88 Hospital
City
Taian
State/Province
Shandong
ZIP/Postal Code
271000
Country
China
Individual Site Status
Completed
Facility Name
Yantai Yu Huang Ding Hospital
City
Yantai
State/Province
Shandong
ZIP/Postal Code
264000
Country
China
Individual Site Status
Completed
Facility Name
Zaozhuang Municipal Hospital
City
Zaozhuang
State/Province
Shandong
ZIP/Postal Code
277100
Country
China
Individual Site Status
Completed
Facility Name
Chang Hai Hospital of the Second Military Medical University
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
200000
Country
China
Individual Site Status
Completed
Facility Name
Ren Ji Hospital of Shanghai Jiao Tong University School of Medicine
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
200000
Country
China
Individual Site Status
Completed
Facility Name
Shanghai Sixth People's Hospital Affiliated Shanghai Jiao Tong University School of Medicine
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
200000
Country
China
Individual Site Status
Completed
Facility Name
The First Hospital of Shanxi Medical University
City
Taiyuan
State/Province
Shanxi
ZIP/Postal Code
030000
Country
China
Individual Site Status
Completed
Facility Name
The Second Hospital of Shanxi Medical University
City
Taiyuan
State/Province
Shanxi
ZIP/Postal Code
030000
Country
China
Individual Site Status
Completed
Facility Name
Shanxi Provincial People's Hospital
City
Xian
State/Province
Shanxi
ZIP/Postal Code
710000
Country
China
Individual Site Status
Completed
Facility Name
The First Affiliated Hospital of Xi'an Jiao Tong University
City
Xian
State/Province
Shanxi
ZIP/Postal Code
710000
Country
China
Individual Site Status
Completed
Facility Name
Hua Xi Hospital of Sichuan University
City
Chengdu
State/Province
Sichuan
ZIP/Postal Code
610000
Country
China
Individual Site Status
Completed
Facility Name
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
City
Tianjin
State/Province
Tianjin
ZIP/Postal Code
300000
Country
China
Individual Site Status
Completed
Facility Name
The Second Hospital of Tianjin Medical University
City
Tianjin
State/Province
Tianjin
ZIP/Postal Code
300000
Country
China
Individual Site Status
Completed
Facility Name
Tianjin Hospital of ITCWM, Nankai Hospital
City
Tianjin
State/Province
Tianjin
ZIP/Postal Code
300000
Country
China
Individual Site Status
Completed
Facility Name
The First Hospital of Shi He Zi Medical University
City
Shihezi
State/Province
Xinjiang
ZIP/Postal Code
832000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xiaoping Yang
Phone
+86-13579458071
Email
sbkyxp@163.com
Facility Name
The Second Affiliated Hospital of Kunming Medical University
City
Kunming
State/Province
Yunnan
ZIP/Postal Code
650000
Country
China
Individual Site Status
Completed
Facility Name
Yan'an Hospital of Kunming City
City
Kunming
State/Province
Yunnan
ZIP/Postal Code
650000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jinwen Wang
Phone
+86-13700697545
Email
wjwyayy@163.com
Facility Name
Zhejiang Provincial People's Hospital
City
Hangzhou
State/Province
Zhejiang
ZIP/Postal Code
310000
Country
China
Individual Site Status
Completed

12. IPD Sharing Statement

Plan to Share IPD
No
Citations:
PubMed Identifier
24631042
Citation
Zhang L, Li P, Xing CY, Zhao JY, He YN, Wang JQ, Wu XF, Liu ZS, Zhang AP, Lin HL, Ding XQ, Yin AP, Yuan FH, Fu P, Hao L, Miao LN, Xie RJ, Wang R, Zhou CH, Guan GJ, Hu Z, Lin S, Chang M, Zhang M, He LQ, Mei CL, Wang L, Chen X. Efficacy and safety of Abelmoschus manihot for primary glomerular disease: a prospective, multicenter randomized controlled clinical trial. Am J Kidney Dis. 2014 Jul;64(1):57-65. doi: 10.1053/j.ajkd.2014.01.431. Epub 2014 Mar 14.
Results Reference
background
PubMed Identifier
28395659
Citation
Li P, Chen YZ, Lin HL, Ni ZH, Zhan YL, Wang R, Yang HT, Fang JA, Wang NS, Li WG, Sun XF, Chen XM. Abelmoschus manihot - a traditional Chinese medicine versus losartan potassium for treating IgA nephropathy: study protocol for a randomized controlled trial. Trials. 2017 Apr 11;18(1):170. doi: 10.1186/s13063-016-1774-6.
Results Reference
derived

Learn more about this trial

Efficacy and Safety of Abelmoschus Manihot for IgA Nephropathy

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