Safety Study of Combining Ultrasound Microbubbles and Chemotherapy to Treat Malignant Neoplasms of Digestive System

Safety Study of Combining Ultrasound Microbubbles and Chemotherapy to Treat Malignant Neoplasms of Digestive System

Safety Study of Combining Ultrasound Microbubbles and Chemotherapy to Treat Malignant Neoplasms of Liver Metastases From Gastrointestinal Tumors and Pancreatic Carcinoma

Ultrasonic sonoporation can increase the release of chemotherapeutics, thus increasing the therapeutic effects. The main purpose is to identify the safety of combining ultrasonic microbubbles and chemotherapeutics to treat malignant neoplasms of hepatic metastases from alimentary system and pancreatic carcinoma.

Ultrasonic sonoporation can increase the release of chemotherapeutics, thus increasing the therapeutic effects. Main purpose To identify the safety of combining ultrasonic microbubbles and chemotherapeutics to treat malignant neoplasms of hepatic metastases from alimentary system and pancreatic carcinoma. To explore the largest mechanical index and ultrasonic treatment time which patients can endure. Secondary purpose To observe tumor clinical benefit rate (CR+PR+SD). To evaluate the preliminary effect,such as time to failure(TTF), time to death(TTD)

In 30min after chemotherapy, inject ultrasonic microbubbles 1 ml once and inject 5 times in 20min and locate the ultrasonic probe on the lesion The chemotherapy of pancreatic is gemcitabine.The chemotherapy of liver metastases is oxaliplatin with taxol.

Chemotherapy drug of pancreatic carcinoma is gemcitabine. Chemotherapy drug of liver metastases is oxaliplatin and taxol.

Inclusion Criteria: Pathological diagnosis of liver metastases from alimentary system and pancreatic carcinoma Failed routine chemotherapy Neoplasms can be evaluated by imaging ECOG《2 Exclusion Criteria: Have systematic chemotherapy in 2 weeks Be allergic to ultrasonic microbubbles and chemotherapeutics Uncontrolled high blood pressure, cardiovascular disease Active bleeding Have serious mental and psychological disease

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