Modufolin (Arfolitixorin) in Combination With 5-Fluorouracil Alone or Together With Oxaliplatin or Irinotecan in Colorectal Cancer
Colorectal Neoplasm
About this trial
This is an interventional treatment trial for Colorectal Neoplasm focused on measuring Colorectal cancer, Colorectal carcinoma, Colorectal tumors, Intestinal Neoplasm, Gastrointestinal Neoplasm, Gastrointestinal disease, 5,10-methylenetetrahydrofolate, Tetrahydrofolates, Therapeutic uses, Pharmacokinetics, Pharmacodynamics, Safety assessments
Eligibility Criteria
Inclusion Criteria:
Advanced metastatic colorectal (Stage IV) cancer verified by biopsy
Sites / Locations
- Odense University Hospital
- 251 General Airforce Hospital
- Medical School University of Athens, Aretaieio Hospital
- Metropolitan General Hospital
- University Genral Hospital Attikon
- University General Hospital of Heraklion
- Oslo University Hospital - Radiumhospitalet
- Oslo University Hospital - Ullevål
- Sahlgrenska University Hospital
- Skaraborg hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Modufolin / Nordic FLV
Modufolin / Nordic FLOX
Modufolin / Nordic FLIRI
MOFOX
MOFOX / Bevacizumab
MOFIRI
Modufolin in combination with 5-Fluorouracil only.
Modufolin in combination with 5-Fluorouracil and Oxaliplatin according to Nordic FLOX regime
Modufolin in combination with 5-Fluorouracil and Irinotecan.
Modufolin in combination with 5-Fluorouracil and Oxaliplatin according to mFOLFOX-6 regime
Modufolin in combination with 5-Fluorouracil, Oxaliplatin and Bevacizumab
Modufolin in combination with 5-Fluorouracil and Irinotecan