Intravenous Paracetamol for Postoperative Pain (IVPARACET)
Pain, Postoperative, Recovery of Function, Child
About this trial
This is an interventional treatment trial for Pain, Postoperative focused on measuring Pain, Postoperative, Paracetamol, Administration, Intravenous, Anti-Inflammatory Agents, Non-Steroidal, Child, Adolescent
Eligibility Criteria
Inclusion Criteria:
- Patients 1-18 years of age, undergoing general, plastic or orthopedic surgery with expected median to severe pain postoperatively.
- physical status of the patient corresponding to American Society of Anesthesiologists (ASA) class 1 or 2
- Signed written informed consent by parents/official caregivers.
Exclusion Criteria:
- Allergy to paracetamol, ketoprofen, tramadol, morphine or any NSAID
- oncologic disease
- central nervous system disease
- renal dysfunction
- hepatic dysfunction
- bronchial asthma
- ulcer(s) in gastrointestinal system
- hemorrhagic diathesis
- chronic use of NSAIDs
- chronic use of opioids
- chronic use of anticoagulants
- female patient is known to be pregnant
Sites / Locations
- Lithuanian University of Health Sciences Kaunas Clinics
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
paracetamol and ketoprofen
placebo and ketoprofen
paracetamol 20 mg/kg (1% 2 ml/kg) IV at the end of surgery 6 and 20 hours thereafter. ketoprofen 1.5 mg/kg IV at the end of surgery 8 and 16 hours thereafter. tramadol 2 mg/kg IV on patient request up til 4 mg/kg or PCA morphine during 24 hours postoperatively.
0.9% sodium chloride (2 ml/kg) IV at the end of surgery 6 and 20 hours thereafter. ketoprofen 1.5 mg/kg IV at the end of surgery 8 and 16 hours thereafter. tramadol 2 mg/kg IV on patient request up til 4 mg/kg or PCA morphine during 24 hours postoperatively.