FMT Versus Antimicrobials for Initial Treatment of Recurrent CDI
Clostridium Difficile Infection
About this trial
This is an interventional treatment trial for Clostridium Difficile Infection focused on measuring CDI, C difficile, C diff, Clostridium difficile
Eligibility Criteria
Inclusion Criteria:
- Diagnosis of active C. difficile infection, defined as > 3 diarrheal stools per day and a positive C. difficile PCR assay
- Hospitalized patient presenting with first relapse of CDI occuring between 15 and 90 days after an index episode of CDI
Exclusion Criteria:
- Pregnancy
- Neutropenia (absolute neutrophil count <1000/microliters)
- Contraindication for retention enema
- Food allergy not controlled in the donor diet
Sites / Locations
- NorthShore University HealthSystem
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
FMT Group (Intervention Arm)
Antimicrobial Group (Control Arm)
Patients randomized to the FMT group will have antimicrobials targeting C. difficile discontinued at least 6 hours prior to undergoing an FMT via retention enema. A second FMT via retention enema will be administered at 24 hours if diarrhea persists.
Patients randomized to the antimicrobial group will be treated with antibiotics targeting C. difficile according to the Society for Healthcare Epidemiology of America (SHEA) Clinical Practice Guidelines for CDI. FMT will be offered to this group after 90 days if they experience relapsing CDI.