Effect of the Addition of Ketamine to Sevoflurane Anesthesia in Electroconvulsive Therapy
Depressive Disorder
About this trial
This is an interventional treatment trial for Depressive Disorder focused on measuring Electroconvulsive therapy; sevoflurane; ketamine
Eligibility Criteria
Inclusion Criteria:
- Major depressive patients
Exclusion Criteria:
- Pregnancy
- Have a history of myocardial infarction in the previous six months
- Atrial fibrillation or flutter
- Heart block
- Unregulated hypertension
- Cerebrovascular diseases
- A known drug allergy
Sites / Locations
- Turgut Ozal Medical CenterRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Placebo Comparator
Group SK
Group SS
Sevoflurane was initiated, in both groups, at 8% for anesthesia induction until loss of consciousness was achieved, at which point it was discontinued. Following loss of consciousness ketamine was administered to Group SK (n=29) in the form of a 0.5mg/kg iv bolus. Patients in Group SS (n=30) received saline in the same manner.
Sevoflurane was initiated, in both groups, at 8% for anesthesia induction until loss of consciousness was achieved, at which point it was discontinued. Patients in Group SS (n=30) received saline in the same manner.