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Associative Memory in Adults With an Autism Spectrum Disorder (MEM-T2A)

Primary Purpose

Autistic Disorder

Status
Unknown status
Phase
Not Applicable
Locations
France
Study Type
Interventional
Intervention
Electroencephalography
Neuropsychological assesments
Sponsored by
University Hospital, Caen
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional health services research trial for Autistic Disorder

Eligibility Criteria

18 Years - 30 Years (Adult)All SexesAccepts Healthy Volunteers

Inclusion Criteria:

  • Adult between 18 and 30 years old
  • right handed
  • affiliated to the french national health care system
  • ASD only for the group of patients

Exclusion criteria :

  • mental retardation
  • schizophrenia
  • ADHD
  • brain injury with lost of consciousness
  • neurological disease

Sites / Locations

  • UMR1077 Inserm/EPHE/UCBNRecruiting

Arms of the Study

Arm 1

Arm 2

Arm Type

Other

Other

Arm Label

Patients

Healthy volunteers

Arm Description

Adults between 18 and 30 years old right handing Patients with ASD

Adults between 18 and 30 years old Right handing Healthy

Outcomes

Primary Outcome Measures

The associative memory index

Secondary Outcome Measures

theta and gamma oscillations during the associative memory task

Full Information

First Posted
June 23, 2014
Last Updated
October 28, 2014
Sponsor
University Hospital, Caen
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1. Study Identification

Unique Protocol Identification Number
NCT02279680
Brief Title
Associative Memory in Adults With an Autism Spectrum Disorder
Acronym
MEM-T2A
Official Title
The Associative Memory in Autism Spectrum Disorders Without Intellectual Disability
Study Type
Interventional

2. Study Status

Record Verification Date
October 2014
Overall Recruitment Status
Unknown status
Study Start Date
June 2014 (undefined)
Primary Completion Date
December 2015 (Anticipated)
Study Completion Date
December 2016 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
University Hospital, Caen

4. Oversight

Data Monitoring Committee
Yes

5. Study Description

Brief Summary
The objective of this multidisciplinary project is to explore the deficit of associative memory in ASD (Autistic Spectrum Disorder) that could result from abnormal brain connectivity. The hypothesis of abnormal functioning of the fronto-hippocampal network has been evocated but has never been tested. Hence, the present project will include two complementary assessments conducted on a group of adults aged from 18 to 30 with ASD compared to a control group matched in chronological age and intellectual quotient. The first assessment is devoted to the study of associative memory and its EEG correlates and the second focused on the investigation of perceptual strategies related to associative memory using the technique of Eye-tracking. Both behavioral and imaging data would provide new insights on the relationship between perception and memory in ASD.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Autistic Disorder

7. Study Design

Primary Purpose
Health Services Research
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Non-Randomized
Enrollment
40 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Patients
Arm Type
Other
Arm Description
Adults between 18 and 30 years old right handing Patients with ASD
Arm Title
Healthy volunteers
Arm Type
Other
Arm Description
Adults between 18 and 30 years old Right handing Healthy
Intervention Type
Device
Intervention Name(s)
Electroencephalography
Intervention Type
Behavioral
Intervention Name(s)
Neuropsychological assesments
Primary Outcome Measure Information:
Title
The associative memory index
Time Frame
2 years
Secondary Outcome Measure Information:
Title
theta and gamma oscillations during the associative memory task
Time Frame
2 years

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
30 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: Adult between 18 and 30 years old right handed affiliated to the french national health care system ASD only for the group of patients Exclusion criteria : mental retardation schizophrenia ADHD brain injury with lost of consciousness neurological disease
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Bérengère GUILLERY-GIRARD, MCU
Phone
0231064347
Email
berengere.guillery@unicaen.fr
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Jean-Marc BALEYTE, PU-PH
Organizational Affiliation
University Hospital, Caen
Official's Role
Principal Investigator
Facility Information:
Facility Name
UMR1077 Inserm/EPHE/UCBN
City
Caen
ZIP/Postal Code
14000
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Bérengère GUILLERY-GIRARD
Phone
0231064347
Email
berengere.guillery@unicaen.fr
First Name & Middle Initial & Last Name & Degree
Pierre DESAUNAY

12. IPD Sharing Statement

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Associative Memory in Adults With an Autism Spectrum Disorder

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