The Comparative Study on Rh-Endostatin (Endostar®) Continuous Intravenous Infusion and Routine i.v in Combination With GP Regimens for Phase III B/IV Squamous Cell Lung Cancer and Biological Markers Exploration.
Primary Purpose
Lung Cancer
Status
Unknown status
Phase
Phase 3
Locations
China
Study Type
Interventional
Intervention
Endostar continuous intravenous infusion
Endostar routine intravenous infusion
Gemcitabine
Cisplatin
Sponsored by
About this trial
This is an interventional treatment trial for Lung Cancer focused on measuring efficacy and safety
Eligibility Criteria
Inclusion Criteria:
- primary lung squamous carcinoma confirmed by cytology and histology, excluding sputum examination.
- phase IIIB /IV based on IASLC 2009 TNM criteria.
- at least one measurable tumor based on RECIST 1.1 ( longest diameter: ≥20 mm by CT scan or 10 mm by spiral CT )
- male or female, age≥18 or ≤75 years old
- ECOG PS: 0 or 1
- estimated time of survival: ≥ 3 months
- suitable hematologic function: ANC≥2×109/L, PLC≥100×109/L and Hb≥9 g/dL
- suitable liver function: Total bilirubin≤normal ULN, AST and ALT≤2.5×normal ULN, ALP≤5×normal ULN.
- suitable renal function: Cr≤normal ULN,or Ccr≥60 ml/min
- EKG normal
- without no healing wound
- no history of anti-cancer therapy, or adjuvant/neo-adjuvant chemotherapy for non-metastatic tumor finished for more than 6 months before enrolment.
- for the female subject with productive ability, urine pregnancy test must be done and is negative within 7 days before enrolment.
- no history of serious allergic to biologic agents, especially E.Coli products
- the authorized ICF must be signed
Exclusion Criteria:
- Woman in pregnancy and breast-feeding, or having productive ability without contraception.
- Having the serious acute infection uncontrolled or purulent/chronic infection with unhealed wound.
- Having the serious heart disease, including congestive heart failure, uncontrolled high-risk arrhythmia, unstable angina, myocardial infarction, valvular disease, and refractory hypertension.
- Having uncontrolled nervous or mental disease with low compliance and reluctance to description of response; uncontrolled primary brain tumor or other metastatic brain cancer with obvious intracranial hypertension or mental symptoms.
- Having the tendency of bleeding, such as FIB<2G/L
- Being receiving adjuvant chemotherapy.
- On other conditions investigator considers, the subject is not fitful to participate the trial.
Sites / Locations
- Tianjin Cancer Hospital
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Active Comparator
Arm Label
Endostar continuous intravenous infusion
Endostar routine intravenous infusion
Arm Description
Endostar continuous intravenous infusion in combination with Gemcitabine and Cisplatin
Endostar routine intravenous infusion in combination with Gemcitabine and Cisplatin
Outcomes
Primary Outcome Measures
objective response rate based on Recist 1.1 edition
progress free survival
Secondary Outcome Measures
overall survival
Quality of life (QoL) Questionnaire
Full Information
NCT ID
NCT02283476
First Posted
November 3, 2014
Last Updated
November 5, 2014
Sponsor
Jiangsu Simcere Pharmaceutical Co., Ltd.
1. Study Identification
Unique Protocol Identification Number
NCT02283476
Brief Title
The Comparative Study on Rh-Endostatin (Endostar®) Continuous Intravenous Infusion and Routine i.v in Combination With GP Regimens for Phase III B/IV Squamous Cell Lung Cancer and Biological Markers Exploration.
Official Title
The Comparative Study on Rh-Endostatin (Endostar®) Continuous Intravenous Infusion and Routine i.v in Combination With GP Regimens for Phase III B/IV Squamous Cell Lung Cancer and Biological Markers Exploration.
Study Type
Interventional
2. Study Status
Record Verification Date
October 2014
Overall Recruitment Status
Unknown status
Study Start Date
November 2014 (undefined)
Primary Completion Date
November 2017 (Anticipated)
Study Completion Date
November 2017 (Anticipated)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Jiangsu Simcere Pharmaceutical Co., Ltd.
4. Oversight
Data Monitoring Committee
No
5. Study Description
Brief Summary
Endostar is a anti-angiogenesis product and has been launched in China . The efficacy and safety have been defined. However, the compliance is unsatisfactory since routine i.v of Endostar is needed for 3 to 4 hours daily during one cycle of 14 days. The continuous intravenous infusion by using venous pump can improve the compliance.The comparative study in efficacy and safety has not been done concerning continuous and routine i.v.In addition, what patient can be benefited from Endostar have not been investigated. The biological markers, such as circulating endothelial cells,CECs, will be explored in the study.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Lung Cancer
Keywords
efficacy and safety
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
200 (Anticipated)
8. Arms, Groups, and Interventions
Arm Title
Endostar continuous intravenous infusion
Arm Type
Experimental
Arm Description
Endostar continuous intravenous infusion in combination with Gemcitabine and Cisplatin
Arm Title
Endostar routine intravenous infusion
Arm Type
Active Comparator
Arm Description
Endostar routine intravenous infusion in combination with Gemcitabine and Cisplatin
Intervention Type
Drug
Intervention Name(s)
Endostar continuous intravenous infusion
Intervention Description
Endostar,7.5mg/m2, continuous intravenous infusion for 14 days each cycle, 21 days as one cycle, 4 cycles in total.
Intervention Type
Drug
Intervention Name(s)
Endostar routine intravenous infusion
Intervention Description
Endostar,7.5mg/m2, routine intravenous infusion 3-4 hours daily each cycle,21 days as one cycle, 4 cycles in total
Intervention Type
Drug
Intervention Name(s)
Gemcitabine
Intervention Description
Gemcitabine,1000-1250mg/m2,i.v d1,d8 in each cycle,21 days as one cycle, 4 cycles in total
Intervention Type
Drug
Intervention Name(s)
Cisplatin
Intervention Description
Cisplatin,75mg/m2,i.v d1 or d1-3 in each cycle,21 days as one cycle, 4 cycles in total
Primary Outcome Measure Information:
Title
objective response rate based on Recist 1.1 edition
Time Frame
3 months
Title
progress free survival
Time Frame
18 months
Secondary Outcome Measure Information:
Title
overall survival
Time Frame
24 months
Title
Quality of life (QoL) Questionnaire
Time Frame
24 months
Other Pre-specified Outcome Measures:
Title
biological marker: CECs
Time Frame
3 months
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
75 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
primary lung squamous carcinoma confirmed by cytology and histology, excluding sputum examination.
phase IIIB /IV based on IASLC 2009 TNM criteria.
at least one measurable tumor based on RECIST 1.1 ( longest diameter: ≥20 mm by CT scan or 10 mm by spiral CT )
male or female, age≥18 or ≤75 years old
ECOG PS: 0 or 1
estimated time of survival: ≥ 3 months
suitable hematologic function: ANC≥2×109/L, PLC≥100×109/L and Hb≥9 g/dL
suitable liver function: Total bilirubin≤normal ULN, AST and ALT≤2.5×normal ULN, ALP≤5×normal ULN.
suitable renal function: Cr≤normal ULN,or Ccr≥60 ml/min
EKG normal
without no healing wound
no history of anti-cancer therapy, or adjuvant/neo-adjuvant chemotherapy for non-metastatic tumor finished for more than 6 months before enrolment.
for the female subject with productive ability, urine pregnancy test must be done and is negative within 7 days before enrolment.
no history of serious allergic to biologic agents, especially E.Coli products
the authorized ICF must be signed
Exclusion Criteria:
Woman in pregnancy and breast-feeding, or having productive ability without contraception.
Having the serious acute infection uncontrolled or purulent/chronic infection with unhealed wound.
Having the serious heart disease, including congestive heart failure, uncontrolled high-risk arrhythmia, unstable angina, myocardial infarction, valvular disease, and refractory hypertension.
Having uncontrolled nervous or mental disease with low compliance and reluctance to description of response; uncontrolled primary brain tumor or other metastatic brain cancer with obvious intracranial hypertension or mental symptoms.
Having the tendency of bleeding, such as FIB<2G/L
Being receiving adjuvant chemotherapy.
On other conditions investigator considers, the subject is not fitful to participate the trial.
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Zhao Yan, Doctor
Phone
18622221369
Email
yanzhao@163.com
Facility Information:
Facility Name
Tianjin Cancer Hospital
City
TianJin
ZIP/Postal Code
300060
Country
China
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jinhuai Xue, Master
Phone
8613502065304
Email
xuejh1210@sina.com
First Name & Middle Initial & Last Name & Degree
Kai Li, Doctor
12. IPD Sharing Statement
Learn more about this trial
The Comparative Study on Rh-Endostatin (Endostar®) Continuous Intravenous Infusion and Routine i.v in Combination With GP Regimens for Phase III B/IV Squamous Cell Lung Cancer and Biological Markers Exploration.
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