Prevention of Infections in Cardiac Surgery (PICS)
Thoracic Surgery, Antibiotic Prophylaxis
About this trial
This is an interventional prevention trial for Thoracic Surgery
Eligibility Criteria
Inclusion Criteria:
- All adult patients (≥18 years of age) undergoing open-heart surgery (sternotomy, including minimally-invasive surgical techniques).
Exclusion Criteria:
- Patients on antibiotics at the time of surgery.
- Previous enrollment in this trial.
- Known MRSA carriers. Beta-lactam allergy (IgE-mediated) precluding the use of cefazolin
- Participant in another study that may interfere with this trial.
Sites / Locations
- Hamilton Health Sciences
- St. Michael's Hospital
- Jewish Hospital
- University of Sherbrook
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Experimental
Experimental
Cefazolin monotherapy, short course
Cefazolin monotherapy, long course
Combination therapy, short course
Combination therapy, long course
One pre-op dose of cefazolin 30-60 minutes prior to surgery followed by a second dose either four hours after the first dose or upon wound closure (whatever comes first) will be administered
One pre-op dose of cefazolin 30-60 minutes prior to surgery followed by a second dose either four hours after the first dose or upon wound closure (whatever comes first) will be administered followed by additional five doses every eight hours postoperatively (last dose 44 hours after the first dose).
One pre-op dose of cefazolin 30-60 minutes prior to surgery followed by a second dose either four hours after the first dose or upon wound closure (whatever comes first) will be administered. In addition, one dose of vancomycin 60-90min pre-op will be administered.
One pre-op dose of cefazolin 30-60 minutes prior to surgery followed by a second dose either four hours after the first dose or upon wound closure (whatever comes first) will be administered followed by additional five doses every eight hours postoperatively (last dose 44 hours after the first dose). In addition, one dose of vancomycin 60-90min pre-op will be administered followed by 3 post-op doses every 12 hours (last dose 36 hours after first dose)