A Phase IV Study Investigating the Effects of Remifentanil Concentrations on Propofol Requirements for Loss of Consciousness, Response to Painful Stimuli, Bispectral Index and Associated Haemodynamic Changes
Induction of Anaesthesia
About this trial
This is an interventional treatment trial for Induction of Anaesthesia
Eligibility Criteria
Inclusion Criteria:
ASA I or II patients (healthy or with mild systemic illness) undergoing planned surgery requiring general anaesthetic
Exclusion Criteria:
- Subjects with pre-existing neurological or psychiatric illness.
- Subjects on CNS acting medication or analgesics.
Sites / Locations
- Queen Mary Hospital
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
remifentanil effect site concentration 0ng/ml
remifentanil effect site concentration 3ng/ml
remifentanil run as an infusion using the minto TCI model, at an effect site concentration of 0 nano grams per millilitre, commenced from start of proposal infusion to point at which patient is anaesthetised and not responding to painful stimuli.
remifentanil run as an infusion using the minto TCI model, at an effect site concentration of 3 nano grams per millilitre, commenced from start of proposal infusion to point at which patient is anaesthetised and not responding to painful stimuli.