CLamp vs Off Clamp Kidney During Partial Nephrectomy (CLOCK)

Prospective, randomized trial comparing surgical, functional and oncological outcomes between clamp and clamp-less robot assisted partial nephrectomy.

Laparoscopic robot-assisted partial nephrectomy with clamping the renal pedicle during the resection of the tumor

Laparoscopic robot-assisted partial nephrectomy without clamping the renal pedicle during the resection of the tumor

number of cases shifted from clampless to clamping procedure; time of suture of the renal parenchyma; overall operative time.

Estimated blood loss; pre/post operative variation of hemoglobin value; overall complications rate; bleeding complications rate

Inclusion Criteria: normal coagulation trim pre operative Glomerular Filtration Rate (GFR) > 60 ml/min healty contralateral kidney low (4-6) or intermediate (7-10) RENAL score availability of Da Vinci Robotic System Exclusion Criteria: altered coagulation trim pre operative Glomerular Filtration Rate (GFR) < 60 ml/min anatomic or functional solitary kidney RENAL score >10

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