Trial to Compare Femoral Nerve Block With Local Anaesthetic Injection for Post-operative Pain After Knee Replacement. (LIFT)
Arthritis Knee
About this trial
This is an interventional treatment trial for Arthritis Knee focused on measuring Total knee arthroplasty, Femoral nerve block, Local infiltration analgesia
Eligibility Criteria
Inclusion Criteria:
All adult patients presenting for primary knee arthroplasty under the care of the Exeter Knee Unit Consultants Messrs Toms, Eyres, Cox, Mandalia, Schrantz.
Exclusion Criteria:
- Total knee arthroplasty for trauma
- Unicompartmental surgery
- Bilateral surgery
- Contra indication to spinal anaesthesia or peripheral nerve blocks (anticoagulation, hydrocephalus, raised intracranial pressure, peripheral neuropathy)
- Allergy to local anaesthetics or morphine
Chronic pain:
- Under active follow up by chronic pain team
- Chronic strong opiate use (morphine, oxycodone, buprenorphine, pethidine, methadone). Codeine, dihydrocodeine and tramadol are not included
- Other chronic pain medications (including gabapentin, pregabalin or amitriptyline)
- Unable to adequately understand verbal explanations or written information given in English, or patients with special communication needs -
Sites / Locations
- Royal Devon and Exeter NHS Foundation Trust
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Femoral nerve block
Local Infiltration Analgesia
Femoral nerve block with 20ml 0.375% Levobupivacaine
Local infiltration of knee joint using 40ml of bupivacaine 0.25% with adrenaline 1:200 000, diluted to 150ml with saline 0.9%. This is then divided into thirds; 50ml into the posterior capsule before cementing, 50ml into the medial and lateral capsules and 50ml into subcutaneous tissues and in and around the vastus medialis and sartorius muscles (where it may block the saphenous nerve).