Ventilation-drive Coupling to Evaluate The Efficacy of Inhaled Bronchodilators in Patients With COPD
Chronic Obstructive Pulmonary Disease (COPD)
About this trial
This is an interventional diagnostic trial for Chronic Obstructive Pulmonary Disease (COPD) focused on measuring COPD, central drive, bronchodilators
Eligibility Criteria
Inclusion Criteria:
Patients aged 40-70 years old; Patients with pulmonary function test of FEV1/FVC < 70% and FEV1%pred < 50%; Patients in a clinically stable state; Patients who signed informed consent.
Exclusion Criteria:
Patients with signs of an airway infection; Patients with an acute exacerbation during the previous 4 weeks; Patients with giant bulla(≥3cm in diameter); Patients with recent upper abdominal surgery; Patients with one or more of the following diseases: esophageal cancer, reflux esophagitis, severe obstructive sleep apnea (apnea hypopnea index>15/hr), neuromuscular disease, or significant heart failure; Patients with poor compliance.
Sites / Locations
- Zhujiang Hospital,Southern Medical Universtiy
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Group A
Group B
The medication order: subjects inhaled placebo,ipratropium bromide 80μg, salbutamol 400μg in sequence.
The medication order: subjects inhaled placebo, salbutamol 400μg, ipratropium 80μg in sequence.