Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial
Post-operative Pain, Gallstone Disease
About this trial
This is an interventional treatment trial for Post-operative Pain focused on measuring pain, calot's triangle, local block, analgesia, patient controlled intravenous analgesia
Eligibility Criteria
Inclusion Criteria:
- men or woman over 18 the years and younger than 65 years old who will receive selective laparoscopic cholecystectomy.
Exclusion Criteria:
- age below 18 years or over 65 years
- American Society of Anesthesiologists grade III or greater
- Diabetes
- chronic pain of any kind other than gallbladder disease
- allergic to local anesthetics
- cognitive impairment or communication problems
- peptic ulcer
- received opioids、NSAID or tranquilizers (treatment for over 1 wk before the cholecystectomy)
- history of alcohol or drug abuse
- the operation was converted to an open procedure
- gangrenous cholecystitis
- common bile duct exploration or insertion of a T-drain
- other invasive procedures
- severe hepatic or renal impairment
- post-operative severe complications(e.g. pyogenic infection)
Sites / Locations
- China,Chongqing The First Affiliated Hospital of Chongqing Medical University
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
CTB group
PCIA group
Participants in this group will receive a single injection for calot's triangle block combined with PCIA post-operatively. CTB will be conducted by bile duct needle and 1.0% 10 ml ropivacaine will be injection in calot's triangle when before surgical dissection.Participants in this group will also receive PCIA after surgery,the regimens of PCIA are included tramadol 800 mg, flurbiprofenaxetil 100 mg with normal saline added up to a volume of 80 ml in total.
Participants in this group will receive PCIA post-operatively (tramadol 800 mg and flurbiprofen axetil 100mg with normal saline added up to a volume of 80ml in total ) .The PCIA pump was set up with a 5 ml loading dose, a 2 ml bolus dose, a 15 min lockout interval and background infusion at a rate of 1 ml/h.