Methylprednisolone for Children With Severe Mycoplasma Pneumoniae Pneumonia (MCMP)
Mycoplasma Pneumoniae Pneumonia
About this trial
This is an interventional treatment trial for Mycoplasma Pneumoniae Pneumonia focused on measuring Severe mycoplasma pneumoniae, pneumonia, children
Eligibility Criteria
Inclusion Criteria:
Severe pneumonia diagnosis criteria were based on the "Zhu Futang Practical Pediatrics" (the 7th Edition) and "the guideline of management of community-acquired pneumonia in children in China"(Chinese Journal of Pediatrics, 2013, 51:745-752, 856-862). Severe pneumonia is defined as pneumonia with one of the following:
- Less than 18 years old
Severe pneumonia that is defined as pneumonia with one of the followings:
- poor general condition
- increased respiratory rate( infant>70/min,older children>50/min)
- dyspnea
- cyanosis
- multilobe involvement or ≥ 2/3 lung involvement
- extrapulmonary complication
- pleural effusion
- Transcutaneous oxygen saturation in room air ≤92%
- Serum M. pneumoniae antibody≥ 1:320, or serum M. pneumoniae antibody≥ 1:160 with positive PCR of M. pneumoniae or seroconversion (increased antibody titers ≥4 folds) Subject/Guardian is informed and consent.
Exclusion Criteria:
Subject will be excluded if she or he has one of the following:
- evidence of bacterial pneumonia;
- evidence of viral pneumonia;
- evidence of fugal pneumonia;
- evidence of pulmonary tuberculosis;
- respiratory failure requiring mechanical ventilation;
- hemophagocytic syndrome;
- liver failure or renal insufficiency;
- congenital heart disease;
- heart failure;
- kidney disease;
- connective tissue disease;
- immunodeficiency;
- tumor;
- a history of hypertension or diabetes mellitus;
- recurrent respiratory tract infection;
- congenital bronchopulmonary dysplasia;
- increased intraocular pressure;
- history of use of glucocorticoids ≥1 week in previous 3 months;
- having contraindications to glucocorticoids or azithromycin;
- using of immunosuppressant before randomization;
- undergoing trial for other medications or instruments.
Sites / Locations
- Beijing Children's Hospital, Capital Medical University
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
low dose group
high dose group
methylprednisolone 2mg-4mg/Kg
methylprednisolone 10mg/Kg