Effect of Infusion of Lidocaine, Magnesium and Remifentanil Perioperatively in Patients Undergoing Mastectomy
Postoperative Pain
About this trial
This is an interventional prevention trial for Postoperative Pain focused on measuring Intravenous lidocaine, Magnesium sulphate, Mastectomy, Pain
Eligibility Criteria
Inclusion Criteria:
- Female patients scheduled for elective surgery performed mastectomy;
- Physical Status P1 and P2 of the American Society of Anesthesiology (ASA);
Exclusion Criteria:
- Patients with less than 18 years and above 75 years of age;
- Patients who are allergic to morphine and / or lidocaine and / or remifentanil and / or magnesium sulphate;
- Patients with chronic pain;
- Patients with severe hepatic disease;
- Patients with severe renal disease;
- Patients with neurological disorders;
- Patients included in other clinical currently or within the past three months under general anesthesia studies;
- Patients who refuse to participate in the study;
- Any other condition that in the opinion of the investigator, may pose a risk to the patient or interfere with the study objectives;
Sites / Locations
- Hospital de Base do Distrito Federal
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Remifentanil group
Lidocaine group
Magnesium group
Magnesium and Lidocaine group
Patients in remifentanil group received an intravenous bolus injection of 2 mg/kg lidocaine followed by a continuous remifentanil infusion of 0,1 mcg/kg/min.
Patients in lidocaine group received an intravenous bolus injection of 2 mg/kg lidocaine followed by a continuous lidocaine infusion of 3 mg/kg/hr.
Patients in lidocaine group received an intravenous bolus injection of 50 mg/kg magnesium sulphate followed by a continuous magnesium sulphate infusion of 15 mg/kg/hr.
Patients received an intravenous bolus injection of 2 mg/kg lidocaine plus 50 mg/kg magnesium sulphate followed by a continuous lidocaine infusion of 3 mg/kg/hr plus 15 mg/kg/hr magnesium sulphate