Confocal Laser Endomicroscopy in IBS Patients
IBS, Food Intolerance
About this trial
This is an interventional treatment trial for IBS
Eligibility Criteria
Inclusion Criteria:
IBS according to the Rome III criteria moderate/severe refractory daily symptoms >1year (FGID-C1) sub classified as IBS-D, constipation predominant (IBS-C) or mixed type (IBS-M) no past infection to trigger symptom no structural/ biochemical cause of their symptoms identified negative gastroscopy, colonoscopy including histology Worsening symptoms after meals various exclusion diets - ineffective females not menstruating during CLE no known allergy to methylene blue or fluorescein Age >18 years Negative routine testing for food intolerance (or known lactose/fructose intolerance) Positive informed consent
Exclusion Criteria:
no consent known reason for the abdominal pain and bloating other than lactose/fructose intolerance M. Whipple Known infectious gastrointestinal disease Stricture in the upper gastrointestinal tract Age <18years Impaired renal function (Creatinine >1.2 mg/dL) Pregnancy or breast-feeding Inability to obtain informed consent Active GI Bleeding Known allergy to Methylene blue or Fluorescein Participation in other clinical trials within the last 4 weeks
Sites / Locations
- University Hospital Schleswig Holstein, Campus Kiel, Unit Experimental Endoscopy
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
FODMAP diet
Specific bread diet
FODMAP diet for 2 weeks, patients will undergo a specific FODMAP diet for a period of 2 weeks.
Specific bread diet eliminating wheat and yeast for 2 weeks, patients will undergo a specific FODMAP diet for a period of 2 weeks.