New Study - Humoral Response to Tick-borne Encephalitis Vaccine in Elderly
Tick-borne Encephalitis
About this trial
This is an interventional prevention trial for Tick-borne Encephalitis focused on measuring immune response, TBE-vaccine, elderly, additional doses
Eligibility Criteria
Inclusion Criteria:
- Age 50 years or more (Control group 18 years)
- generally healthy
- no immunosuppressive condition
- fertile women must use contraceptives
Exclusion Criteria:
- Previous TBE infection
- Previously immunized with TBE vaccine
- Anaphylactic reaction to egg protein
- Any disease or therapy which might suppress the immune response
- Vaccination should be delayed if a participant has fever
Sites / Locations
- Dept infectious diseases
- Dept infectious diseases
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
TBE vaccine at 0+30 days
TBE vaccine at 0+7+21 days
TBE vaccine at 0+30+90 days
younger participants
double dose of vaccine
This group of 50 participants will follow the standard recommendation and will be given TBE vaccine 0.5 ml FSME immune at 0 + 30 days during the first year and an additional dose one year later
This group of 50 participants will will be given TBE vaccine 0.5 ml FSME immune at 0 + 7 +21 days during the first year and an additional dose one year later
This group of 50 participants will will be given TBE vaccine 0.5 ml FSME immune at 0 + 30 + 90 days during the first year and an additional dose one year later
This group of 50 participants in the age group 18-49 years will be given TBE vaccine 0.5 ml FSME immune at 0 +30 days during the first year and an additional dose one year later
This group of 50 participants will be given two doses of TBE vaccine 0.5 ml FSME immune at the first day of the study and an additional dose at day 30 as well as one year later